Collaborations

MRC Laboratory of Molecular Biology, Cambridge

Leo is a biophysicist and crystallographer with whom we take a structure function approach to our favourite biological questions.

Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC. . Nature. 2016 Aug 18;536(7616):349-53. Epub 2016 Aug 10.

Rasaiyaah, J., C. P. Tan, A. J. Fletcher, A. J. Price, C. Blondeau, L. Hilditch, D. A. Jacques, D. L. Selwood, L. C. James, M. Noursadeghi and G. J. Towers. 2013. . Nature (2013) doi:10.1038/nature12769

Bichel, K., A. J. Price, T. Schaller, G. J. Towers, S. M. Freund, and L. C. James. 2013. . Retrovirology 10:81.

Price, A. J., A. J. Fletcher, T. Schaller, T. Elliot, K. Lee, V. N. Kewalramani, J. Chin, G. J. Towers, and L. C. James. 2012. . PLoS pathogens 8:e1002896

Caines, M. E., K. Bichel, A. J. Price, W. A. McEwan, G. J. Towers, B. J. Willett, S. M. Freund, and L. C. James. 2012. . Nat Struct Mol Biol 19:411-416.

Ylinen, L. M., Price, A. J., Rasaiyaah, J., Hue, S., Rose, N. J., Marzetta, F., James, L. C. & Towers, G. J. 2010. . PLoS Pathogens 6: e1001062

Mallery, D. L., W. A. McEwan, S. R. Bidgood, G. J. Towers, C. M. Johnson, and L. C. James. 2010. . Proceedings of the National Academy of Sciences of the United States of America 107:19985-19990.

Price, A. J., F. Marzetta, M. Lammers, L. M. J. Ylinen, T. Schaller, S. J. Wilson, G. J. Towers and L. C. James. 2009. . Nature Struct Mol Biol 16: 1036-42

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Division of Infection and Immunity, UCL

We collaborate with Maddy to understand how HIV-1 interacts with the innate immune system. Maddy helped us set up replication experiments in primary monocyte derived macrophages. Plus Maddy owns a speedboat.

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Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK. Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.

Towers GJ, Noursadeghi M. . Cell Host Microbe. 2014 Jul 9;16(1):10-8. doi: 10.1016/j.chom.2014.06.009.

Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK.. Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.

Hughes R, Towers G, Noursadeghi M. Rev Med Virol. 2012 Jul;22(4):257-66. doi: 10.1002/rmv.1708. Epub 2012 Feb 22. Review.

Tomlinson, G. S., H. Booth, S. J. Petit, E. Potton, G. J. Towers, R. F. Miller, B. M. Chain, and M. Noursadeghi. 2012. PloS one 7:e40348.

Schaller, T., K. E. Ocwieja, J. Rasaiyaah, A. J. Price, T. L. Brady, S. L. Roth, S. Hue, A. J. Fletcher, K. Lee, V. N. Kewalramani, M. Noursadeghi, R. G. Jenner, L. C. James, F. D. Bushman, and G. J. Towers. 2011.. PLoS Pathog 7:e1002439

Tsang, J., B. M. Chain, R. F. Miller, B. L. J. Webb, W. Barclay, G. J. Towers, D. R. Katz, and M. Noursadeghi. 2009.. AIDS 23:2255-63

Ylinen LM, Schaller T, Price A, Fletcher AJ, Noursadeghi M, James LC, Towers GJ. J Virol. 2009 Feb;83(4):2044-7. doi: 10.1128/JVI.01876-08. Epub 2008 Dec 10.

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Dr St茅phane Hu茅

Department of Infectious Disease Epidemiology, LSHTM

Dr St茅phan Hu茅 We collaborate with St茅phane to consider the genetics of host and virus using phylogenetic and positive selection techniques.

Monit C, Goldstein RA, Towers G, Hu茅 S. AIDS Res Hum Retroviruses. 2015 Oct;31(10):947. doi: 10.1089/AID.2015.0150. Epub 2015 Jul 22.

Gupta, K. R., S. Hu茅, T. Schaller, E. Verschoor, D. Pillay and G. J. Towers. 2009. . PloS Pathogens 5:e1000443

Ylinen, L. M., Price, A. J., Rasaiyaah, J., Hue, S., Rose, N. J., Marzetta, F., James, L. C. & Towers, G. J. 2010. . PLoS Pathogens 6: e1001062

Fletcher AJ, Hu茅 S, Schaller T, Pillay D, Towers GJ. J Virol. 2010 Dec;84(23):12463-8. doi: 10.1128/JVI.01514-10. Epub 2010 Sep 22.

Hu茅 S, Gray ER, Gall A, Katzourakis A, Tan CP, Houldcroft CJ, McLaren S, Pillay D, Futreal A, Garson JA, Pybus OG, Kellam P, Towers GJ. Retrovirology. 2010 Dec 20;7(1):111. doi: 10.1186/1742-4690-7-111.

Katzourakis A, Hu茅 S, Kellam P, Towers GJ. J Virol. 2011 Oct;85(20):10909-13. doi: 10.1128/JVI.00827-11. Epub 2011 Aug 17.

Schaller T, Hu茅 S, Towers GJ. J Virol. 2007 Nov;81(21):11713-21. Epub 2007 Aug 29.

Division of Infection and Immunity, UCL

Ravi is a clinical Virologist and Wellcome Trust Intermediate Clinical Fellow. Ravi is interested in how host virus interactions influence disease outcome in patients.

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Mlcochova P, Caswell SJ, Taylor IA, Towers GJ, Gupta RK. . EMBO J. 2018 Jan 4;37(1):50-62. doi: 10.15252/embj.201796880. Epub 2017 Oct 30.

Mlcochova P, Sutherland KA, Watters SA, Bertoli C, de Bruin RA, Rehwinkel J, Neil SJ, Lenzi GM, Kim B, Khwaja A, Gage MC, Georgiou C, Chittka A, Yona S, Noursadeghi M, Towers GJ, Gupta RK. EMBO J. 2017 Mar 1;36(5):604-616. doi: 10.15252/embj.201696025. Epub 2017 Jan 25.

Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK. Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.

Gupta, R. K., Kohli, A., McCormick, A. L., Towers, G. J., Pillay, D.,and C. M. Parry. 2010. . AIDS 24:1651-5

Gupta, R. K. and G. J. Towers. 2009. Cell Host and Microbes 5: 393-5

Gupta, K. R., S. Hu茅, T. Schaller, E. Verschoor, D. Pillay and G. J. Towers. 2009. . PloS Pathogens 5:e1000443

Gupta, R. K., P. Mlcochova, A. Pelchen-Matthews, S. J. Petit, G. Mattiuzzo, D. Pillay, Y. Takeuchi, M. Marsh, and G. J. Towers. 2009. . Proc Natl Acad Sci U S A 106: 20889-20894

Division of virology, NIBSC

Dr Neil Berry We collaborate with Neil and his colleagues at the National Institute for Biological Standards, part of the MHRA, to understand the correlates of protection of live attenuated vaccination of non-human primates with simian immunodeficiency virus. Neil has found that a live attenuated vaccine provides particularly effective protection from homologous and heterologous lentivirus challenge. Our work has considered the role of restriction factors and the innate immune system generally in protection with the view to developing an HIV-1 vaccine that produces a similar protective response.

Ferguson D, Mattiuzzo G, Ham C, Stebbings R, Li B, Rose NJ, Mee ET, Smith D, Page M, Cranage MP, Almond N, Towers GJ, Berry NJ. PLoS One. 2014 Aug 27;9(8):e104390. doi: 10.1371/journal.pone.0104390. eCollection 2014.

Mattiuzzo G, Rose NJ, Almond N, Towers GJ, Berry N. . Gen Virol. 2013 Mar;94(Pt 3):606-11. doi: 10.1099/vir.0.047795-0. Epub 2012 Nov 14.

Berry NJ, Marzetta F, Towers GJ, Rose NJ. . 2012 Apr;64(4):267-78. doi: 10.1007/s00251-011-0585-x. Epub 2011 Nov 29.

Berry N, Ham C, Mee ET, Rose NJ, Mattiuzzo G, Jenkins A, Page M, Elsley W, Robinson M, Smith D, Ferguson D, Towers G, Almond N, Stebbings R. PLoS One. 2011;6(8):e23092. doi: 10.1371/journal.pone.0023092. Epub 2011 Aug 10.

Prof David Selwood

Wolfson Institute for Biomedical Research, UCL

Dave is a medicinal chemist听 with a focus on cyclosporines. We collaborate with Dave to develop non immunosuppressive analogues of Cyclosporine that might be used as inhibitors of HIV-1 replication. These molecules are also useful tools for the study of primate lentiviral biology.

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Culley S, Towers GJ, Selwood DL, Henriques R, Grove J. . Viruses. 2016 Jul 21;8(7). pii: E201. doi: 10.3390/v8070201.

Warne J, Pryce G, Hill JM, Shi X, Lenner氓s F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AW, Towers GJ, Coker AR, Duchen MR, Szabadkai G, Baker D, Selwood DL. J Biol Chem. 2016 Feb 26;291(9):4356-73. doi: 10.1074/jbc.M115.700385. Epub 2015 Dec 17.

IrsiCaixa, Institut de Reserca de la Sida, Barcelona

Dr Julia Garc铆a Prado We collaborate with Julia to understand the biology of HIV antigen presentation and antiviral mechanisms of TRIM5.

Jimenez-Moyano E, Ruiz A, Kl酶verpris HN, Rodriguez-Plata MT, Pe帽a R, Blondeau C, Selwood DL, Izquierdo-Useros N, Moris A, Clotet B, Goulder P, Towers GJ, Prado JG. J Virol. 2016 Sep 12;90(19):8552-62. doi: 10.1128/JVI.00819-16. Print 2016 Oct 1.

Kl酶verpris HN, Payne RP, Sacha JB, Rasaiyaah JT, Chen F, Takiguchi M, Yang OO, Towers GJ, Goulder P, Prado JG. 2013. Journal of Virology 87(5):2628-38

Prof Richard Milne

Department of Virology, UCL Medical School

Dr Richard Milne Richard leads infection and immunity teaching at 911爆料网 and is recipient of numerous teaching awards. Together with Greg and the Towers lab, he is developing a research-led teaching programme in which senior investigators and post-docs teach undergraduate lectures based on their most recent and exciting discoveries. We aim not only to teach science facts but also to teach students how to think like scientists. Richard and Greg run a London-wide monthly seminar programme: Virtual Virology, and a public engagement programme for school children.

Sumner RP, Thorne LG, Fink DL, Khan H, Milne RS, Towers GJ. Front Immunol. 2017 Oct 6;8:1246. doi: 10.3389/fimmu.2017.01246. eCollection 2017.

Blondeau, C., A. Pelchen-Matthews, P. Mlcochova, M. Marsh, R. S. Milne, and G. J. Towers. Tetherin Restricts Herpes Simplex Virus Type 1 and is Antagonised by Glycoprotein J.Virol. 2013 Sep 25

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Dr Joe Grove

Division of Infection and Immunity, UCL

Joe works on Hepatitis C virus. We collaborate with Joe on novel antivirals that inhibits a range of flaviviruses. We also greatly value Joe's expertise in cell biology and light microscopy and his contributions to our lab meetings.

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Si芒n Culley,听Greg J Towers,听David L Selwood,听Ricardo Henriques,听Joe Grove Viruses听2016 Jul 21;8(7):201.听doi: 10.3390/v8070201.

Division of Infection and Immunity, UCL

Richard is an computational biologist in our Dept at 911爆料网ho studies virus and host evolution. We believe that biological data make most sense when considered in the context of evolution. In collaboration with Richard we consider ways to ask questions that combine evolutionary and molecular biology experimental approaches.

Monit C, Goldstein RA, Towers G, Hu茅 S. AIDS Res Hum Retroviruses. 2015 Oct;31(10):947. doi: 10.1089/AID.2015.0150. Epub 2015 Jul 22.

University Of Surrey

Carlos studies pox viruses in his group at the University of Surrey. We collaborate with Carlos because pox viruses manipulate DNA sensing and comparing and contrasting replication and innate immune evasion strategies between pox viruses and retroviruses is very informative.

Georgana I, Sumner RP, Towers GJ, Maluquer de Motes C. . J Virol. 2018 Feb 28. pii: JVI.02145-17. doi: 10.1128/JVI.02145-17.

Division of Infection and Immunity, UCL

Clare is a cell biologist aiming to understand how HIV-1 transmits from one cell to another. We share lab meetings with Clare and Clare's group have a big input on interpretation of observations made in the lab. We find having more than one PI in the lab meeting is really helpful for discussion and interpretation of new data.

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Virology Research Services Ltd

ICH and Great Ormond Street Hospital

Dr Waseem Qasim We collaborate with Waseem on developing novel gene therapy based approaches to treat HIV infection in children.

Chan E, Towers GJ, Qasim W. . 2014 Jan 14;6(1):243-63. doi: 10.3390/v6010243. Review.

Chan, E., T. Schaller, A. Eddaoudi, H. Zhan, C. P. Tan, M. Jacobsen, A. J. Thrasher, G. J. Towers, and W. Qasim. 2012. . Human gene therapy. 23:1176-85

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Faculty of Medicine, University of New South Wales

David is a structural biologist at the University of New South Wales in Australia. We work with David to understand how lentiviral capsids work and how they regulate encapsidated viral DNA synthesis.

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling.听 Fletcher AJ, Vaysburd M, Maslen S, Zeng J, Skehel JM, Towers GJ, James LC. Cell Host Microbe. 2018 Dec 12;24(6):761-775.e6. doi: 10.1016/j.chom.2018.10.007. Epub 2018 Nov 29.听 PMID:30503508.

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.听 Mallery DL, M谩rquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, B枚cking T, James LC.听 Elife. 2018 May 31;7. pii: e35335. doi: 10.7554/eLife.35335. PMID:29848441

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.听 Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC.听 Nature. 2016 Aug 18;536(7616):349-53. Epub 2016 Aug 10.听 PMID: 27509857

Dr Che Colpitts

Queens University, Ontario, Canada

Che spent three years as a research fellow with us funded by Canadian fellowships and a grant from the UCL/UCLH Biomedical Research Centre. Che taught us how to work on flaviviruses with a focus on Hepatitis C (HCV). Che worked out that if you inhibit HCV with cyclosporines then the antiviral protein PKR is activated to provide activiral acivity via IRF1 published in eLife. Che now helps us understand how innate immunity works against Dengue Virus funded by an MRC project grant co-written with Che. We were sorry to see Che go but very happy to see her success in setting up and funding her own lab at Queens University in Canada.

Colpitts CC, Ridewood S, Schneiderman B, Warne J, Tabata K, Ng CF, Bartenschlager R, Selwood DL, Towers GJ. 2020 Hepatitis C virus exploits cyclophilin A to evade PKR. 听Elife. Jun 16;9:e52237. doi: 10.7554/eLife.52237.

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MRC-University of Glasgow Centre for Virus Research (CVR)

Rob is a computational biologist working at CVR. His insight into viral evolution has helped us understand viral protein function and we are now convinced that nothing makes sense unless considered through the lens of evolution.

EM photographer

Steve is a photographer who uses a scanning electron microscope to take pictures. We collaborate with Steve by providing infection related samples for him to photograph. Steve's pictures can be seen on his website

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Quantitative Biosciences Institute (QBI) at the University of California San Francisco (UCSF)

Krogan lab (Mehdi Bouhaddou, Greg Towers, Lorena Zuliani-Alvarez, Nevan krogan), 2022

We have worked closely with Nevan and his team on SARS-CoV-2 since establishing our collaboration through Lorena. We have collaborated to study responses to SARS-CoV-2 infection with Nevan鈥檚 lab performing mass spectrometry, RNA sequencing and structural biology.

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Jose F Varona,听Pedro Landete,听Jose A Lopez-Martin,听Vicente Estrada,听Roger Paredes,听Pablo Guisado-Vasco,听Lucia Fernandez de Orueta,听Miguel Torralba,听Jesus Fortun,听Roberto Vates,听Jose Barberan,听Bonaventura Clotet,听Julio Ancochea,听Daniel Carnevali,听Noemi Cabello,听Lourdes Porras,听Paloma Gijon,听Alfonso Monereo,听Daniel Abad,听Sonia Zu帽iga,听Isabel Sola,听Jordi Rodon,听Julia Vergara-Alert,听Nuria Izquierdo-Useros,听Salvador Fudio,听Maria Jose Pontes,听Beatriz de Rivas,听Patricia Giron de Velasco,听Antonio Nieto,听Javier Gomez,听Pablo Aviles,听Rubin Lubomirov,听Alvaro Belgrano,听Belen Sopesen,听Kris M White,听Romel Rosales,听Soner Yildiz,听Ann-Kathrin Reuschl,听Lucy G Thorne,听Clare Jolly,听Greg J Towers,听Lorena Zuliani-Alvarez,听Mehdi Bouhaddou,听Kirsten Obernier,听Briana L McGovern,听M Luis Rodriguez,听Luis Enjuanes,听Jose M Fernandez-Sousa,听Nevan J Krogan,听Jose M Jimeno,听Adolfo Garcia-Sastre. Life Science Alliance 2022 Jan 10;5(4):e202101200. doi: 10.26508/lsa.202101200. Print 2022 Apr.

Lucy G Thorne,听Mehdi Bouhaddou,听Ann-Kathrin Reuschl,听Lorena Zuliani-Alvarez,听Ben Polacco,听Adrian Pelin,听Jyoti Batra,听Matthew V X Whelan,听Myra Hosmillo,听Andrea Fossati,听Roberta Ragazzini,听Irwin Jungreis,听Manisha Ummadi,听Ajda Rojc,听Jane Turner,听Marie L Bischof,听Kirsten Obernier,听Hannes Braberg,听Margaret Soucheray,听Alicia Richards,听Kuei-Ho Chen,听Bhavya Harjai,听Danish Memon,听Joseph Hiatt,听Romel Rosales,听Briana L McGovern,听Aminu Jahun,听Jacqueline M Fabius,听Kris White,听Ian G Goodfellow,听Yasu Takeuchi,听Paola Bonfanti,听Kevan Shokat,听Natalia Jura,听Klim Verba,听Mahdad Noursadeghi,听Pedro Beltrao,听Manolis Kellis,听Danielle L Swaney,听Adolfo Garc铆a-Sastre,听Clare Jolly,听Greg J Towers,听Nevan J Krogan. Nature, 2022 Feb;602(7897):487-495. doi: 10.1038/s41586-021-04352-y. Epub 2021 Dec 23.

Lucy G Thorne,听Mehdi Bouhaddou,听Ann-Kathrin Reuschl,听Lorena Zuliani-Alvarez,听Ben Polacco,听Adrian Pelin,听Jyoti Batra,听Matthew V X Whelan,听Manisha Ummadi,听Ajda Rojc,听Jane Turner,听Kirsten Obernier,听Hannes Braberg,听Margaret Soucheray,听Alicia Richards,听Kuei-Ho Chen,听Bhavya Harjai,听Danish Memon,听Myra Hosmillo,听Joseph Hiatt,听Aminu Jahun,听Ian G Goodfellow,听Jacqueline M Fabius,听Kevan Shokat,听Natalia Jura,听Klim Verba,听Mahdad Noursadeghi,听Pedro Beltrao,听Danielle L Swaney,听Adolfo Garcia-Sastre,听Clare Jolly,听Greg J Towers,听Nevan J Krogan. BioRxiv, 2021 Jun 7;2021.06.06.446826. doi: 10.1101/2021.06.06.446826. Preprint

Jos茅 F Varona,听Pedro Landete,听Jose A Lopez-Martin,听Vicente Estrada,听Roger Paredes,听Pablo Guisado-Vasco,听Luc铆a Fern谩ndez de Orueta,听Miguel Torralba,听Jes煤s Fort煤n,听Roberto Vates,听Jos茅 Barber谩n,听Bonaventura Clotet,听Julio Ancochea,听Daniel Carnevali,听Noem铆 Cabello,听Lourdes Porras,听Paloma Gij贸n,听Alfonso Monereo,听Daniel Abad,听Sonia Z煤帽iga,听Isabel Sola,听Jordi Rodon,听Nuria Izquierdo-Useros,听Salvador Fudio,听Mar铆a Jos茅 Pontes,听Beatriz de Rivas,听Patricia Gir贸n de Velasco,听Bel茅n Sopes茅n,听Antonio Nieto,听Javier G贸mez,听Pablo Avil茅s,听Rubin Lubomirov,听Kris M White,听Romel Rosales,听Soner Yildiz,听Ann-Kathrin Reuschl,听Lucy G Thorne,听Clare Jolly,听Greg J Towers,听Lorena Zuliani-Alvarez,听Mehdi Bouhaddou,听Kirsten Obernier,听Luis Enjuanes,听Jose M Fern谩ndez-Sousa,听Plitidepsin 鈥� COVID - 19 Study Group;听Nevan J Krogan,听Jos茅 M Jimeno,听Adolfo Garc铆a-Sastre. MedRxiv, 2021 May 25;2021.05.25.21257505. doi: 10.1101/2021.05.25.21257505. Preprint

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Ann-Kathrin Reuschl,听Lucy G Thorne,听Lorena Zuliani-Alvarez,听Mehdi Bouhaddou,听Kirsten Obernier,听Joseph Hiatt,听Margaret Soucheray,听Jane Turner,听Jacqueline M Fabius,听Gina T Nguyen,听Danielle L Swaney,听Romel Rosales,听Kris M White Pablo Avil茅s,听Ilsa T Kirby,听James E Melnyk,听Ying Shi,听Ziyang Zhang,听Kevan M Shokat,听Adolfo Garc铆a-Sastre,听Clare Jolly,听Gregory J Towers,听Nevan J Krogan. BioRxiv, 2021 Feb 4;2021.01.24.427991. doi: 10.1101/2021.01.24.427991. Preprint