Nanomedicine and Surgical Theranostics
Our work
Our current research aims include:
- New nanoparticles for surgical oncology to enable improved intraoperative imaging and targeted therapy.Â
- Investigation of ablative techniques for surgery (e.g., ultrasound, near-IR irradiation, cryotherapy) and their combination with chemotherapy as adjuvants to surgery.
- Developing tumouroid 3D in vitro cultures of cancer, which mimic the composition and architecture of solid tumours as platforms for testing therapeutics and stratified medicine.
- Clinical trials in surgical oncology and renal cancer ablation and diagnostics.
- Treatment of infections using nanoparticles with antimicrobial properties.
Our facilities
- 3D model fabrication and culture of primary cells for cancer
- Nanoparticle manufacture
- Reactive oxygen species detection using time-resolved spectroscopy
- High power laser irradiation
- Ultrasound delivery
- Thermal imaging
- NIR imaging
The Centre for Nanomedicine and Surgical Theranostics (CNS)
Principal Investigators from laboratory and surgical disciplines work alongside postdoctoral, graduate researchers and students. To foster our interdisciplinary approach, we have strong links with other UCL departments, including Chemistry, the School of Pharmacy and Engineering.
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Deputy ±á±ð²¹»å:Ìý
Dr Hazel Welch
Honorary staff
Funding / Partnerships
Current research funding is drawn from the EPSRC, MRC, Innovate UK, British Council, NIHR (National Institute for Health Research), the Royal Society UK, and charitable sources.
We also work closely with industrial partners. An example of this is nanoparticle testing in experimental cancer models.
Select publications
Neves JB, Warren H, Santiapillai J, Rode N, Cullen D, Pavlou M, Walkden M, Patki P, Barod R, Mumtaz F ... Gurusamy K, Emberton M, Bex A, Tran MGB (2023). . Eur Urol. 2023 S0302-2838(23)03012-9.
Banerjee SM, Acedo P, El Sheikh S, Harati R, Meecham A, Williams NR, Gerard G, Keshtgar MRS, MacRobert AJ, Hamoudi R (2023).Ìý. Front Immunol. 2023 14:1188087.
- Hadi MM, Farrell S, Nesbitt H, ... MacRobert AJ, McHale JP, Nomikou N. et al. (2022). . J Cancer Res Clin Oncol.
- Eddama, M.M.R., Gurung, R., Fragkos, K., Lorgelly, P., Cohen, R., Loizidou, M., & Clapp, L. (2022). . Cancer Medicine.
- Nyga A., Stamati K., Hamoudi R., Tran M.G.B., Emberton M., Loizidou M., Cheema U., et al. . J. Cell Commun. Signal. 2022.
- Hadi M.M., Sciscione F., Emberton M., MacRobert A., McHale A.P., Nomikou N., et al. . J.Control Release. 2021 Jan 10;329:76-86.
- Stamati K., Neves J.B., Tran M.G., Emberton M, Cheema U, Loizidou M.J., et al. . Tissue Eng. 2020 11:2041731420920597
- Hwang G.B., Huang H., Wu G., Shin J., Kafizas A., MacRobert A.J., et al. . Nature Com. 2020 11(1):1207.
- Banerjee S.M., El-Sheikh S., Malhotra A., Mosse C.A., MacRobert A.J., Hamoudi R., et al. . J Clin. Med. 2020 10;9(2):483.
- Gulamhusein A., Silva P., Cullen D., Tran M., Mumtaz F., Bex A., et al. . BJU Int. 2020.
- Owusu EGA, MacRobert AJ, Naasani I, Parkin IP, Allan E, Yaghini E. . ACS Appl. Mater. Interfaces. 2019 11(13):12367-12378.
- Azimi T, Loizidou M, Dwek MV. . Sci Rep. 2020 21;10(1):12020.
- Neves JB, Cullen D, Grant L, Gurusamy K, Emberton M, Bex A, Tran MGB., et al. . BMJ Open. 2019 11;9(6):e030965.