Bioengineering and Surgical Technology
Our work
Musculoskeletal conditions are the most common cause of severe long-term pain and physical disability.
The success of musculoskeletal procedures relies on the development of materials combined with surgical techniques. Most joint replacements are used to replace worn out and damaged cartilage associated with osteoarthritis. Many other procedures involve the treatment of soft tissue injuries.
Our work increases the success of these procedures. We develop technology to replace, restore and regenerate musculoskeletal tissues through the interaction of innovative materials with surgical techniques, cells, and tissues.
What we do
Research: Translational stem cell research applied to scaffold materials used for the regeneration of musculoskeletal tissues. This involves an investigation of cell augmented scaffold and implants to enhance fixation to the bone and repair of tendons and ligaments.
Innovate surgical techniques associated with medical devices.
Develop innovative scaffolds, materials, and devices to regenerate, repair and replace the musculoskeletal system. These include the development of calcium phosphate bone graft substitutes, soft tissue scaffolds for tendon and ligament repair, and the use of new materials for osteochondral scaffolds.
Retrieve and analyse retrieved implants including joint replacements and spinal devices. We use retrieval data such as wear of implant articulating surfaces with patient details to assess implant success and predict performance. Our role informs surgeons and regulatory authorities about the failure of musculoskeletal devices.
Investigate new methods of reducing by killing or preventing biofilm formation on device surfaces. This work is associated with the development of bactericidal surfaces, anti-fouling implants and the use of new techniques to kill biofilms.
Our facilities
The Centre for Bioengineering and Surgical Technology
±á±ð²¹»å:Ìý
Select publications
- Buzasi, E., Kurakata, H., Gandhi, A., Birch, H.L., Zarnegar, R. & Best, L. (2022). . Pain.
- Horga, L. M., Henckel, J., Fotiadou, A., Di Laura, A., Hirschmann, A. & Hart, A. (2021). . BMJ Open Sport & Exercise Medicine, 7 (2), e000997.
- Ilo, K. C., Aboelmagd, K., Hothi, H. S., Asaad, A., Skinner, J. A. & Hart, A.J. (2021).  Hip International, ARTN 1120700019873637.
- Horga, L.M., Henckel, J., Fotiadou, A., Di Laura, A., Hirschmann, A. & Hart, A. (2021). . Orthopaedic Journal of Sports Medicine.
- Selim, O., Lakhani, S., Midha, S., Mosahebi, A. & Kalaskar, D.M. (2021). . Tissue Eng Part B Rev.
- Eley, K. A., Moazen, M., Delso, G., Javidan, M., Kalaskar, D.M., et al. (2021). . Journal of Craniofacial Surgery.
- Yin, N.H., McCarthy, I. & Birch, H.L. (2021). . Acta Biomater.
- Farini, A., Sitzia, C., Villa, C., Cassani, B., Tripodi, L., Cerletti, M., et al. (2021). . Nat Commun, 12 (1), 2099. doi:10.1038/s41467-021-22305-x
- Hale, L., Linley, E. & Kalaskar, D.M. (2020). . Scientific Reports.
- Osagie-Clouard, L., Kaufmann, J., Blunn, G., Pendegrass, C., et al. (2019). . Journal of Orthopaedic Research.
- Ulag, S., Ilhan, E., Sahin, A., Karademir Yilmaz, B., Kalaskar, D.M., Ekren, N., et al. (2020). . European Polymer Journal, 109744.
- Burzyn, D., Wagers, A., Mathis, D. & Cerletti, M. (2019). . Methods Mol Biol, 1899, 229-237.