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Applied Renal Physiology Course

Date of next course: May 2025 (exact dates to be confirmed)

Overview

The Applied Renal Physiology course will be held in-person at a conference venue in central London (location to be confirmed)

The courseÌýcoversÌýthe pathophysiology and clinical management of electrolyte and acid-base disorders, hypertension and fluid management.ÌýThe course consists of a mixture of basic and applied clinical science and willÌýprovide a useful overview of renal physiology.

The course is run over three daysÌýbut you can choose to attend for one, two or three days. Each day will involve face-to-face lectures and case discussions from international physiology and nephrology experts.

Learning outcomes:

The course will help you:

  • understand the principles of acid-base and renal electrolyte physiology
  • evaluate and treat common and traditionally difficult clinical problems such as hyponatraemia and metabolic acidosis
  • practice clinical physiology cases with world-expert clinicians in dedicated workshops
  • gain expertise with fluid and diuretic therapies
  • critically reflect on ways to improve current practice and the patient pathway

Who is this course for?

The courseÌýis for:

  • trainees in nephrology, general (internal) medicine and intensive care medicine
  • consultant nephrologists
  • general practitioners

Course Programme

Day 1:Ìý

The morning session on Day 1 isÌýintended as a refresher in the basics of renal physiology

  • Overview of the nephron
  • Proximal tubular function
  • Distal tubular function
  • Clinical tubular cases

The afternoon session on Day 1 provides an update on renal physiology (topics to be confirmed)

Day 2:ÌýÌý

  • Renal tubular acidosis
  • Metabolic acidosis and alkalosis
  • Acid-base physiology
  • Acid-base cases workshop
  • Hyponatraemia
  • Hypernatraemia
  • IV fluid therapy
  • ³§´Ç»å¾±³Ü³¾Ìý³¦²¹²õ±ðÌý·É´Ç°ù°ì²õ³ó´Ç±è²õ

Day 3:Ìý

  • Hypokalaemia
  • Hyperkalaemia
  • Hypophosphataemia
  • Magnesium disorders
  • Calcium disorders
  • Phosphate, magnesium, potassium and calcium cases workshop
  • Diuretics
  • Online MCQs

Days two and threeÌýprovideÌýa comprehensive overview of fluids, electrolytes and acid-base for clinicians and will cover background physiology and clinical sciences.Ìý Each day will feature an interactive workshop.Ìý These two days will particularly benefit those practicing in nephrology, critical care or any acute medical specialities.

Teaching and structure

You can attend one, two or three days.

Each day will involve face-to-face lectures and case discussions from international physiology and nephrology experts.

This is an interactive course and we encourage you to ask questions, bring your own clinical queries or cases and chat informally with our speakers during breaks.

CPD Accreditation

Previous courses have been awarded 15-18Ìýexternal CPD points byÌýtheÌýRoyal College of Physicians UKÌýand we anticipate the 2025 course to be awarded the same.ÌýTheÌýÌýprovides accreditation as a supportiveÌýprocess of evaluating the quality of clinical services and promotes quality improvement through highlighting areas of best practice and areas for change, encouraging the continued development of the clinical service.

Certificate of Attendance

Your Certificate of Attendance will be emailed to you after the course.

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Contact us

Please don't hesitate to get in touchÌýif you have any queries about the course.

Kate Henderson, UCL Department of Renal Medicine, Royal Free Campus, Rowland Hill Street, London NW3 2PF.Ìý

Email:Ìý Med.Cfnevents@ucl.ac.uk

Tel:Ìý 020 8016 8264

Course Directors

Professor in Renal Medicine, UCL Department of Renal Medicine/Honorary Consultant Nephrologst, Royal Free LondonÌý NHSÌýFoundation Trust

Ben Walsh is a clinician scientist with an interest in both rare renal tubular disorders and disorders of blood pressure. He leads a specialist national clinic for patients with inherited and acquired renal tubular disease.

His research involves the physiology of renal epithelial sodium and other solute transport, and how that relates to blood pressure homeostasis, in rare genetic (Gitelman and Gordon syndromes, distal Renal Tubular Acidosis) as well as common (hypertension, metabolic syndrome) diseases. His laboratory group, the , uses physiological and imaging methods with cell and animal models as well as human subjects.

Matthew Bailey is Professor of Renal Physiology in the British Heart Foundation Centre for Cardiovascular Science at the University of Edinburgh and a Fellow of The Royal Society of Biology. He has a PhD from The University of London, received postdoctoral training at 911±¬ÁÏÍø and CNRS in Saclay, France and held Wellcome Trust Fellowships at Yale University and the University of Edinburgh. Matt's team examines the physiology of salt balance and is funded by the British Heart Foundation, Kidney Research UK, Diabetes UK and the Medical Research Council.

Rhys Evans is a Consultant Nephrologist and Associate Professor in the UCL Department of Renal Medicine. He was an undergraduate at Cambridge University, undertook general nephrology training in London, and he subsequently completed a Fellowship in Transplantation at the University of British Columbia. He returned to the Royal Free in November 2021 where he works clinically as a transplant nephrologist and is deputy lead of the Centre for Transplantation. Rhys undertook his PhD at 911±¬ÁÏÍø under the supervision of Prof Alan Salama and ProfÌýStephen Walsh. His research is focused on the impact of the extracellular ionic environment on immune cell activation with a particular focus on changes in immunity that occur in states of altered sodium balance. He recently provided the first report of immunodeficiency in a patient with Salt-Losing Tubulopathy. He has just received funding to explore the effect of sodium on the alloimmune response.

Dr. Keith Siew is a Sir Henry Wellcome Postdoctoral Fellow at University College London, where he co-leads an interdisciplinary team of clinicians, scientists and engineers investigating the pathophysiology and aetiology of rare electrolyte and blood pressure disorders. He previously completed a PhD in Medicine at the University of Cambridge in collaboration with Dundee University investigating monogenicÌýsyndromes impacting the distal nephron, and trained as an experimental physiologist-pharmacologist (BSc [Hons]) and advanced microscopist (MSc) at University College Dublin. He has published several papers on the mechanisms underpinning regulation of the blood pressure and renal tubular function in monogenic syndromes, arterial stiffness biomarkers and identified strategies to develop new classes of therapies that could be used to treat resistant cohorts. His current research focuses on developing novel techniques to investigate how the kidneys control our body’s electrolyte-water balance and blood pressure in both health and disease. These techniques have employed imaging of optically cleared renal biopsies for 3D histopathology, isolation and characterisation of urine-derived kidney tubule cells for rare disease patients for organ-on-a-chip systems, and the use of environmental extremes such to study renal physiology (e.g. humans and mice that have been exposed to real spaceflight and/or galactic cosmic radiation).

Disclaimer

All best endeavours will be made to present the programme as advertised. However, the Course Administration reserves the right to alter or cancel, without prior notice, any arrangements, timetables, plans or other items relating directly or indirectly to the Course for any cause beyond its reasonable control.ÌýOccasionally, due to unforeseen circumstances, a course may have to be cancelled. In this situation, we will endeavour to give as much notice as possible and you will receive a full refund for the course cost. We cannot, however, refund other incurred expenses, for example pre-purchased travel or accommodation.

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