Description
In a series of research lectures given by UCL neuroscientists you will learn how the fundamental biophysical properties of neurones and their ion channels, neurotransmitters and their receptors contribute to neuronal processing in health and disease.
There is also an optional introductory week focussing on the passive properties (electrical equivalent circuit of a neurone, length constant, time constant, Nernst potentials etc.).
Indicative lecture titles
Week 1: voltage-gated ion channels
- Introduction to Ion Channels
- Voltage-gated Ca2+ -channels: their role in disease
- Voltage-gated Na+-channels: targets for anti-epileptics and neuroprotectors
- Voltage-gated K+-channels: from structure to disease
Week 2: chemical neurotransmission
- Presynaptic mechanisms
- Nicotinic receptors
- Analysis of gating and kinetics of ligand-gated ion channels: theory and applications
- Ligand-gated ion channels in synaptic transmission
Week 3: neuronal inhibition
- Introduction to neuronal inhibition
- GABAA receptors in central transmission
- GABAA receptor functioning and trafficking
- GABABR's: function and dynamics
Week 4: synaptic integration and plasticity
- Introduction to synaptic integration and plasticity
- Integration of synaptic transmission
- Modulation of encoding and integrative properties of neurones by K+-channels
- Memories are made of this...
Module deliveries for 2024/25 academic year
Last updated
This module description was last updated on 19th August 2024.
Ìý