Description
The course will give an overview of the basic information required to build up a picture of the physicochemical properties of a potential drug candidate and how this information is used to (i) make a decision on the likely developability of a compound and (ii) inform and direct likely formulation strategy. Key concepts to be introduced include solubility, partitioning, acid-base chemistry, dissolution behavior and effect of physical form. The use of the data to inform formulation strategy will be achieved with reference to case studies of marketed products and/or generic drug delivery devices.
List of lectures:
- Introduction to preformulation
- Solubility
- Dissolution & partitioning
- Crystalline materials
- Pseudopolymorphs
- Amorphous materials
- Salts
- Solid amorphous dispersions
- Workshop: Problem-based learning on preformulation
Module deliveries for 2024/25 academic year
Last updated
This module description was last updated on 19th August 2024.
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