Metabolism and Inflammation
Our missionÂ
- Contribute to the health of low / middle-income communities by investigating the burden of non-communicable diseases (NCDs) on them using an omics approach.
- Focusing on the inflammatory processes linking NCDs, both as cause and consequence, to metabolic dysfunction.
- Tailoring diagnostics and therapeutics based on these findings using camelid antibodies.
Research at the Centre of Metabolism & Inflammation: 1st Annual Symposium
The first annual symposium for research at the Centre of Metabolism & Inflammation took place on 12 September 2024 at the Royal College of Physicians.
The keynote address was made by Prof. Dame Carol Black DBE. Other contributions came from members of CoMI, the UCL Institute of Cardiovascular Science and ADLQ.
Our experts
Prof. Mohammed Al-Maadheed
Dr Chidambaram Manickam
Dr Konduru Seetharama Sastry
Dr Maneera Al-Jabr
Dr Mark Stuart
- PhD students
Fatima Al-Hatimy
Investigation of the strategic decision-making process and assessment of its impact on Qatar’s healthcare system
Previous work recommended the use of rational decision-making, through strategic planning in order to improve the healthcare system in Qatar, specifying planning as a governance issue, and advocating a need for planning controls and monitoring capacity. This project is conducting a thorough quantitative assessment, using NCDs as a case study of the impact of changes within Qatar’s healthcare system, and benchmarks it against countries of similar size and government, such as Singapore.
Nada Mohamed-Ali
Investigation of Camel-derived Antibodies & VHH Fragments in Inflammatory Fibrotic Disease Â
The association between chronic, sub-clinical inflammation and several metabolic diseases is well established. Interleukin-6 (IL-6) has been shown to be an important regulator of fibrosis in insulin-responsive organs, such as the liver, adipose tissue, skeletal muscle and the heart. The cytokine appears to mediate the process leading to permanent scaring that fails to return the tissue to normal function. Â The therapeutic potential of IL-6 suppression in diabetes-associated tissue fibrosis is an area of intense research activity.
Dr Maryam AlNesf Al Mansouri
Noor Al-Naimi
Ijeoma Ibeawuchi
- Master's students
Ibrahim Al-Mohannadi
- Interns
Fatima Al-Musleh (Summer 2024)
Selected publications
- Elmadhoun S, Mansi M, Kamal R, Al-Kuwari K, Mohamed-Ali V, Al-Maadheed MÌý(2024). Exploring the Relationship Between Injury, Addiction, and Physical Activity: A Path to Recovery for Athletes. Annals of Clinical and Medical Case Reports. (Accepted.)
- Stuart M, Farooq M, Thomas T, Mohamed-Ali N, Al-Maadheed M, Mohamed-Ali V (2024). . Sports Med Open. 2024 Jul 19;10(1): 80.
- Siew K, Nestler KA, Nelson C, D'Ambrosio V ... Al-Maadheed M, et al (2024). . Nat Commun. 2024 Jun 11;15(1): 4923.
- Chamari K, Kamal R, Mohamed-Ali V, Al-Maadheed M (2024). . New Asian Journal of Medicine, 2(1), 27-31.
- Mazzarino M, Al-Mohammed H ... Mohamed-Ali V, Al-Maadheed M (2024). . J Pharm Biomed Anal. 2024 May 15;242: 116007.
- Aboujassoum HM, Mohamed-Ali V, et al (2023). . Nutrients. 2023 Dec;16(1): 115.
- Schmidt F, Abdesselem HB ... Mohamed-Ali V, Al-Maadheed M, et al (2023). . Front Physiol. 2023 Jul 14;14: 1203723.
- El-Agnaf O, Bensmail I ... Al-Maadheed M, Mohamed-Ali V, et al (2023). . Neurobiol Dis. 2023 Jun 15;182: 106147.
- Bettahi I, Krishnankutty R … Mohamed-Ali V, et al (2023). . Front Endocrinol (Lausanne). 2023 Feb 17;13: 1024832.
- Voss SC, Yassin M, Grivel JC ... Mohamed Ali V, Georgakopoulos C, Al Maadheed M (2022). . Drug Test Anal. 2022 Nov;14(11-12): 1984-1994.
- Yu F, Courjaret R, Elmi A, Adap EA ... Mohamed-Ali V, Machaca K (2022). . J Physiol. 2022 Nov;600(22): 4827-4848.
- Shen L, Dashwood MR, Casale C ... Mohamed-Ali V (2022). . Life Sci. 2022 Sep 15;305: 120756.
- Aljaber MY, Orie NN, Raees A, Kraiem S, Al-Jaber MÌý...ÌýMohamed-Ali V, Almaadheed M (2022). . Future Sci OA. 2022 Jul 7;8(6):FSO805.
- Ullah E, El-Menyar A, Kunji K ... Al-Maadheed M, Mohamed-Ali V, et al (2022). . Metabolites. 2022 Jun 3;12(6): 517.
- AlJaber M, Abushreeda W, Raees A ... Mohamed-Ali V, Al Maadheed M, Lund G (2022). . Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, Vol. 44(1): 35212-35219, May.
- Al-Nesf A, Mohamed-Ali N, Acquaah V, Al-Jaber M ... Mohamed-Ali V, Al-Maadheed M (2022). . Metabolites. 2022 May 10;12(5): 425.
- Al-Nesf MAY, Abdesselem HB, Bensmail I ... Al-Maadheed MÌý... Mohamed-Ali V, Al-Ejeh F (2022). . Nat Commun. 2022 Feb 17;13(1): 946.
- Al-Hatimy F, Farooq A, Al Abiad M, Yerramsetti S ... Mohamed-Ali V, Al-Maadheed M (2022). . Int J Environ Res Public Health. 2022 Feb 17;19(4): 2266.
- Orie NN, Raees A, Aljaber MY, Mohamed-Ali N  … Mohamed-Ali V, Almaadheed M (2021).Ìý. Phytomedicine Plus, Vol. 1(3).
- Ventura R, Daley-Yates P, Mazzoni I ... Stuart M (2021). . Br J Sports Med. 2021 Apr 20.
Funding and partnershipsÂ
Prof. Vidya Mohamed-Ali is a Scientific Advisor to the Anti-Doping Lab Qatar and a member of the Medical & Scientific Committee of the International Olympic Committee. She has contributed to over 100 conference proceedings and media output for the wider public (such as the British Nutrition Foundation Task Force publications) and attracted funding for several student stipends. She has obtained grant funding of £1.95 million and published over 90 peer-reviewed papers, four reviews and contributed chapters to three books. Her work has been cited over 6,000 times, with an H-index of 52.
Related programmes
Contact Details
Telephone
Postal Address
UCL Division of Medicine
Royal Free Hospital Campus
Rowland Hill Street
Hampstead
London
NW3 2PF