Fibrosis and Tissue Repair
Our workÌý
Our current research interest is fibrogenesis with focus on Hepatic Stellate Cell behaviour in liver fibrosis and liver cancer cell biology with a specific focus on fibrotic stroma - cancer cell interaction.ÌýFurther interests include genetic polymorphism heterogeneity - cell behaviour in diseases such as Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis and cancer development.
The Team’s research remit covers both identifying/characterization of human organ specific Extracellular Matrix and cellular components of tissues, with a specific focus on cell behaviour in 2D and 3D cell culture systems for improvement of new target identification and drug development.Ìý
Together with the ENETS oncology team of the Royal Free Hospital we are exploring mesenteric fibrosis in small intestinal neuroendocrine tumours:
- pathogenesis and potential therapeutic targets
- early biomarker detection in mesenteric fibrosis
- Deep Sequencing of gastroenteropancreatic neuroendocrine carcinoma.
Our experts
(Lead)
Professor of Experimental Hepatology
Emeritus Professor
Honorary Associate Professor
Honorary Research Fellow
Marlon Lemos Dias
International Researcher
Dr Peng Dai
Research Fellow
Dr Yan Jun
Research Fellow
Research Assistant
NHS collaborators
Gastroenterology &Ìýneuroendocrine
Gastroenteorology &Ìýneuroendocrine
Consultant medical oncologist
Interventional vascular & uroradiologist
Dr Amir Gander
HTA Designated Individual,ÌýTissue Access
Dr Dalvinder S. Mandair
PhD students
- Maria Inês Castanho Martins
- Saiji Kathiresu Nageshwaran
- Giulia Lupo
Ìý
Selected publications
Al-Akkad W, Acedo P, Vilia MG ...ÌýHall AR ...ÌýLuong TV, Whittaker SR, Pereira SP,ÌýVallier L, Pinzani M, Rombouts K, Mazza G (2022). . Cells. 2022 Nov 17;11(22):3652.
Thanapirom K, Caon E, Papatheodoridi M, Frenguelli L, Al-Akkad W, Zhenzhen Z, Vilia MG, Pinzani M, Mazza G, Rombouts K (2021). . Cancers (Basel). 2021 Sep 30;13(19):4936.
Laskaratos FM, Levi A, Schwach G, Pfragner R, Hall A, Xia D, von Stempel C ...ÌýLuong TV, Toumpanakis C, Mandair D, Caplin M, Rombouts K (2021).Ìý. Frontiers Oncology. 2021 Feb 24;11:629665. eCollection 2021.
Dat NQ, Thuy LTT, Hieu VN ...ÌýRombouts K, Dong MP, Hanh NV ...ÌýPinzani M, Kawada N (2021). . Hepatology. 2021 Jun;73(6):2527-2545.ÌýEpub 2021 May 22. Erratum in: Hepatology. 2022 Dec;76(6):1902.
Böttcher K, Longato L, Marrone G, Mazza G, Ghemtio L, Hall A, Luong TV, Caruso S, Viollet B, Zucman-Rossi J, Pinzani M, Rombouts K (2021).Ìý. Am J Physiol Gastrointest Liver Physiol. 2021 Apr 1;320(4):G543-G556.
Pavlović N, Calitz C, Thanapirom K, Mazza G, Rombouts K, Gerwins P, Heindryckx F (2020). . Elife. 2020 Oct 26;9:e55865.
Zanieri F, Levi A, Montefusco D ...ÌýLuong TVÌý...ÌýMazza G, Argemi J, Bataller R, Cowart LA, Kester M, Pinzani M, Rombouts K (2020).Ìý. Cells. 2020 May 16;9(5):1237.
Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K ...ÌýPinzani M, Kawada N. . Journal of Hepatology. 2020 Apr 17. pii: S0168-8278(20)30228-2.
Barcena-Varela M, Paish H, Alvarez L ...ÌýRombouts K, Oakley F, Mann J, et al (2020).Ìý. Gut. 2020 Apr 23. pii: gutjnl-2019-320205.
Kostrzewski T, Maraver P, Ouro-Gnao L, Levi A, Snow S, Miedzik A, Rombouts K*, Hughes D* (2019). . Hepatology Communication. 2019 Nov 13;4(1):77-91.ÌýeCollection 2020 Jan. (*Contributed equally)
Mazza G, Telese A, Al-Akkad W, Frenguelli L, Levi A ...ÌýHall AR, Godovac-Zimmermann J, Luong TV, De Coppi P, Pinzani M, Rombouts KÌý(2019).Ìý. Cells. 2019 Dec 28;9(1). pii: E83.
Laskaratos FM, Mandair D, Hall A, Alexander S, von Stempel C, Bretherton J, Luong T, Watkins J, Ogunbiyi O, Rombouts K, Caplin M, Toumpanakis CÌý(2020). . Endocrine. 2020 Mar;67(3):718-726.
De Chiara F, Thomsen KL, Habtesion A ...ÌýHall A, Andreola F, Paish HL, Reed LH, Watson AA, Leslie J, Oakley F, Rombouts K, et alÌý(2020). . Hepatology. 2020 Mar;71(3):874-892.
Giuffrida P, Curti M, Al-Akkad W, Biel C, Crowley C, Frenguelli L, Telese A, Hall A ...ÌýPinzani M, Di Sabatino A, *Rombouts K, *Mazza GÌý(2019).Ìý. Inflamm Bowel Dis. 2019 Oct 18;25(11):1740-1750.Ìý(*Contributed equally.)
Marrone G, De Chiara F, Böttcher K, Levi A, Dhar D, Longato L, Mazza G, Zhang ZZ, Marrali M, Fernández-Iglesias A, Hall A, Luong TV, Viollet B, Pinzani M, Rombouts K (2018). . Hepatology. 2018 Sep;68(3):1140-1153.
Böttcher K, Rombouts K, Saffioti F, Roccarina D, Rosselli M, Hall A, Luong TV, Tsochatzis EA, Thorburn D, Pinzani M (2018).Ìý. Hepatology. 2018 Jul;68(1):172-186.
Mazza G, Al-Akkad W, Telese A, Longato L, Urbani L, Robinson B, Hall AÌý...ÌýRombouts K, Pinzani M (2017). . Scientific Report. 2017 Jul 17;7(1):5534. PubMed PMID: 28717194
Carloni V, Lulli M, Madiai S, Mello T, Hall A, Luong TV, Pinzani M, *Rombouts K, *Galli A (2017).Ìý. Gut. 2018 Feb;67(2):348-361.
Longato L, Andreola F, Davies SS, Roberts JL, Fusai G, Pinzani M, Moore K, Rombouts K (2017). . Free Radic Biol Med. 2017 Jan;102:162-173.
Jalan R, De Chiara F, Balasubramaniyan V, Andreola F, Khetan V, Malago M, Pinzani M, Mookerjee RP, Rombouts K (2016). . Journal of Hepatology. 2016 Apr;64(4):823-33.
Funding and partnerships
European Crohn's and Colitis Organisation
Neuroendocrine Tumor Research Foundation
NIHR UCL Hospitals BRC
Technology Strategy Board (Innovative UK)
Royal Free Charity
Fiorina Foundation
Industrial Partners: CNBio Innovations
Industrial Partners:ÌýDefiniGEN Ltd
Related programmes
Our members contribute to the MBBS, iBSc, BSc and master’s degrees within the Division of Medicine. We provide BSc and MSc/MRes research project supervision. We also have an established track record in providing high-quality training to PhD students interested in basic, translational, and clinical research in the areas of liver, pancreas, and biliary diseases.
Contact details
- Email: Prof. Krista Rombouts (k.rombouts@ucl.ac.uk)
Address
Division of Medicine, Institute for Liver and Digestive Health Ìý
UCL Medical School
Upper 3rd Floor Royal Free Hospital
LONDON
NW3 2QG