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Biophysics of genome structure and repair
Our research group studies the molecular mechanisms of protein-DNA interactions that underpin the structure and maintenance of the genome. 听We combine biophysical and biochemical approaches with cutting-edge fluorescence microscopy and force spectroscopy to understand how these proteins function in health and disease. A particular focus of the lab is the study of DNA repair enzymes. DNA in the cell is constantly subjected to a variety of types of damage such as strand breaks and base modifications. DNA repair enzymes scan the genome for damage and repair them through a number of different pathways. 听Failure to correctly repair DNA damage can lead to cancer and other diseases. We are interested in studying the mechanisms of the DNA repair process including how these proteins recognize different DNA damage structures and how small molecule drugs can alter their dynamics. By understanding the fundamental processes by which these proteins work we hope to inform the progression of new therapies. Our lab also has a strong interest in the development of techniques to study DNA and protein dynamics at high temporal and spatial resolution down to the level of single-molecules. We specialize in force spectroscopy using magnetic tweezers/nanopores and single-molecule fluorescence imaging. 听
We welcome enquiries about joining our research group - please听contact听Dr Nicholas Bell.