Ariberto Fassati

Professor of Cellular and Molecular Virology

Research areas

Molecular host-virus interactions
Nucleocytoplasmic trafficking of viruses and tRNAs
Transmissible cancers

Research programme

Viral immunity

Research summary

We investigate host-pathogen interactions by chemical genetics. Chemical genetics is an approach whereby small molecules are first screened to find 'hits' with the desired phenotype and then the hit molecule is used as a tool to identify the target by genetic and biochemical means. Using this approach, we have identified several new targets for HIV-1 infection and novel cellular pathways. Our experience is that often this kind of research leads to fundamental discoveries on the function of mammalian cells.

We use biophysical and biochemical approaches to understand the fundamental mechanisms regulating how large macromolecules, including viruses, go across the nuclear pore complex. We do this in collaboration with colleagues at the London Centre for Nanotechnology.

We also have a long-standing interest in the canine transmissible venereal tumour (CTVT), one of three clonally transmissible cancers in nature. We study the interactions between this tumour and the host immune system and how tolerance to CTVT is broken, leading to its regression. We investigate how cancer can become transmissible. We believe that CTVT may be a good model to understand the co-evolution of cancer and the immune system.

Publications

Selected publications

Schwenzer H, J眉hling F, Chu A, Pallett LJ, Baumert TF, Maini M, Fassati A.听听Cell Rep. 2019. 26(12):3416-3428.e5.
Schwenzer H, Fassati A听听Cancer Cell. 2019. 35(1):5-7.
Fassati A.听听Mol Cell Oncol. 2018. 5(4):e1472059.听
Frampton D, Schwenzer H, Marino G, Butcher LM, Pollara G, Kriston-Vizi J, Venturini C, Austin R, de Castro KF, Ketteler R, Chain B, Goldstein RA, Weiss RA, Beck S, Fassati A.听听Cancer Cell. 2018. 33(4):620-633.e6.听
Zhyvoloup A, Melamed A, Anderson I, Planas D, Lee CH, Kriston-Vizi J, Ketteler R, Merritt A, Routy JP, Ancuta P, Bangham CRM, Fassati A.听听PLoS Pathog. 2017. 13(7):e1006460.听
Weiss RA, Fassati A.听听Cell. 2015. 161(2):191-2.
Satou Y, Katsuya H, Fukuda A, Misawa N, Ito J, Uchiyama Y, Miyazato P, Islam S, Fassati A, Melamed A, Bangham CRM, Koyanagi Y, Sato K.听.听Sci Rep. 2017. 7:6913
Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P.听.听JCI Insight. 2017. 2.pii:93230
Stanley GJ, Fassati A, Hoogenboom BW.听.听Semin Cell Dev Biol. 2017. 68:42-51
Weiss RA, Fassati A.听.听Cell. 2015. 161:191-2
Chen NY, Zhou L, Gane PJ, Opp S, Ball NJ, Nicastro G, Zufferey M, Buffone C, Luban J, Selwood D, Diaz-Griffero F, Taylor I, Fassati A.听.听Retrovirology. 2016. 13:28
McCoy LE, Rutten L, Frampton D, Anderson I, Granger L, Bashford-Rogers R, Dekkers G, Strokappe NM, Seaman MS, Koh W, Grippo V, Kliche A, Verrips T, Kellam P, Fassati A, Weiss RA.听.听PLoS Pathog. 2014. 10:e1004552
Bestembayeva A, Kramer A, Labokha AA, Osmanovi膰 D, Liashkovich I, Orlova EV, Ford IJ, Charras G, Fassati A*, Hoogenboom BW*.听.听Nat Nanotechnol. 2015. 10:60-64 (*joint senior authors)
Murchison EP, Wedge DC, Alexandrov LB, Fu B, Martincorena I, Ning Z, Tubio JMC, Werner EI, Allen J, De Nardi AB, Donelan EM, Marino G, Fassati A, Campbell PJ, Yang F, Burt A, Weiss RA, Stratton MR.听.听Science. 2014. 343(6169):437-440
Anderson I, Low JS, Weston S, Weinberger M, Zhyvoloup A, Labokha AA, Corazza G, Kitson RA, Moody CJ, Marcello A, Fassati A.听.听Proc Natl Acad Sci U S A. 2014. 111:E1528-37.

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