Understanding how changes in DNA secondary structure cause the proteome to age
20 June 2022
![G-quadruplexes](/biosciences/sites/biosciences/files/styles/large_image/public/g-quadruplexes.jpg?itok=A_Fk2m-_)
A research team led by Dr. John Labbadia has been awarded £1.3M by the BBSRC to determine how changes in the formation and resolution of DNA secondary structures across the genome impact the proteome and long-term tissue health.
The work is a partnership between UCL (, ) and Imperial College London () and will provide a foundation for the development of molecules that reshape the genome and proteome to promote healthy human ageing.
Image: Crystal structure of parallel quadruplexes from human telomeric DNA. The DNA strand (blue) circles the bases that stack together in the center around three co-ordinated metal ions (green). Credit:Â