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Many archaea use ESCRT-III to divide, but how is it controlled? In a ,听迟丑别听Baum lab shows that the proteasome, which is conserved in both eukaryotes and archaea, is key to the process. It triggers cell division by selectively targeting a structural ESCRT-III filament (purple) at the final stage of cell division, thereby freeing the contractile ESCRT-III filament (green) to constrict the cells.聽