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In a world where scientific discoveries have the potential to transform lives, nurturing the next generation of scientists is essential. Now in its second year, this summer placement aimed to inspire and equip future scientists with the skills and knowledge necessary to tackle some of the world鈥檚 most complex challenges鈥攏eurological disorders. This year鈥檚 focus was functional genomics and the use of animal models, such as Drosophila, to explore the frontiers of neurogenetics.

From the very first day, students were immersed in the fast-paced, multidisciplinary world of scientific research. Dr. Rauan Kaiyrzhanov opened the week by highlighting the importance of studying underrepresented populations, such as those from Central Asia and Transcaucasia. By increasing diversity in genetic research, we can uncover rare variants and gene-environment interactions that drive discoveries benefiting humanity as a whole.

Master鈥檚 student Reagan Lee introduced the group to PCR techniques used in Sanger sequencing to test genetic variants, offering students a hands-on look at the molecular techniques behind genetic diagnostics.

Throughout the week, postdoctoral researchers Simon Lowe, Abigail Wilson, and Gabriel Aughey guided students through the fascinating use of Drosophila鈥攖he fruit fly鈥攁s a model for human disease. Students observed genetic phenotypes under microscopes and conducted behavioural assays, while also gaining practical experience in confocal microscopy. These advanced imaging techniques revealed how neuronal activity and structural changes in the brain and neuromuscular junction relate to movement disorders.

PhD student Kristina Zhelcheska delved into gene therapy and immunohistochemistry, demonstrating their critical role in decoding cellular structures. Research technician Ellie Self further enriched the students鈥� experience by explaining the importance of DNA quantification and fragment analysis, particularly in diagnosing conditions like Spinocerebellar Ataxia. These activities provided a direct connection between lab work and real patient outcomes.

In addition, PhD student Natalia Dominik led immersive exercises where students honed precise laboratory techniques, including pipetting, PCR, and gel electrophoresis. Nathan Routledge, also a PhD student, introduced his research on sodium voltage-gated ion channels and their link to neurological disorders. He also provided a detailed overview of how patient blood samples are handled in ALS research. Tracy Lau further broadened their understanding by discussing her work on cerebral palsy and how advanced data analysis can unlock the mysteries of complex neurodevelopmental disorders.

In a world where misinformation can distort public understanding of science, bridging the gap between researchers and society is more important than ever. Research Coordinator Rahema Mohammad emphasized this during her session on science communication and public engagement. She discussed current work on improving gastrostomy practices for patients with Atypical Parkinsonism syndromes, a project supported by the MSA Trust. By connecting scientific research with public needs, these initiatives not only enhance understanding but also accelerate progress in vital research areas like MND and Alzheimer's.

Why These Placements Matter: Building the Next Generation of Scientists

This year鈥檚 Summer Work Experience Placement at the Neurogenetics Lab did more than provide students with knowledge鈥攊t equipped them with the skills and inspiration to envision their future in science. By the end of the week, the students weren鈥檛 just familiar with the basics of neurogenetics; they were energized and ready to explore the vast opportunities within scientific research.

One student reflected: "This week has been incredibly insightful. I experienced so many unique yet vital roles that I wouldn鈥檛 have discovered otherwise."

In an era defined by scientific and technological advancements, experiences like this are more important than ever. They not only bridge the gap between academic theory and real-world application, but they also demystify the scientific process, making it tangible and inspiring students to become tomorrow鈥檚 innovators and problem-solvers. The program鈥檚 emphasis on hands-on learning and direct engagement with cutting-edge research provides students with the practical skills needed to thrive in scientific careers.

Moreover, programs like this are pivotal in promoting diversity and inclusion in science. By offering students from all backgrounds the opportunity to engage with research, the Neurogenetics Lab is helping to create a more inclusive scientific community鈥攐ne that reflects the diverse populations it serves.

As the world grapples with complex health and environmental challenges, the need for programs like this has never been greater. By investing in our students, we are investing in the future of scientific discovery. These young minds will one day be the ones finding cures for diseases, solving global crises, and shaping a better world for all.

CEO at Social Mobility Foundation 鈥� Sarah Atkinson:聽鈥淲e were delighted to collaborate once again with the Neurogenetics Lab on this exciting programme. The placement offered students so many inspiring opportunities to build knowledge and skills and develop their networks. We look forward to continuing to work together to inform and inspire aspiring young scientists.鈥�

Testimonials

鈥淭his experience has been extremely useful as it has provided me with valuable insight into life in a lab. Furthermore, it has provided me with invaluable knowledge and skills which I can apply to any aspect of my life鈥�

鈥淭his experience has prepared me for many future skills in the medical field as well as having opened my eyes to the endless diversity in job roles and studies in science.鈥�

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• Neurogenetics Lab

• The Neurogenetics Lab Summer Work Experience 2023