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/Prev 379 0 R /Parent 343 0 R /Next 381 0 R >> endobj 381 0 obj << /Dest [5 0 R /XYZ 86 707 null] /Title (Welcome from the Director of Postgraduate Studies \(Research\), Ariberto Fassati MD PhD ) /Prev 380 0 R /Parent 343 0 R /Next 382 0 R >> endobj 382 0 obj << /Dest [5 0 R /XYZ 72 693 null] /Title ( ) /Prev 381 0 R /Parent 343 0 R /Next 383 0 R >> endobj 383 0 obj << /Dest [5 0 R /XYZ 72 679 null] /Title ( ) /Prev 382 0 R /Parent 343 0 R /Next 384 0 R >> endobj 384 0 obj << /Dest [5 0 R /XYZ 71 668 null] /Title (Figure) /Prev 383 0 R /Parent 343 0 R /Next 385 0 R >> endobj 385 0 obj << /Dest [5 0 R /XYZ 163 665 null] /Title (\215The future of medical research depends on the training of the best scientists and clinician scientists who will become leaders in their field. Maintaining the pool of excellence is a challenge that requires long-term vision and commitment. Our PhD programme is a critical part of this vision. We welcome applications from the best graduates who are committed to strive for excellence in science. With us, they will receive outstanding training, guidance and support to prepare them becoming leaders in their fie) /Prev 384 0 R /Parent 343 0 R /Next 386 0 R >> endobj 386 0 obj << /Dest [5 0 R /XYZ 72 567 null] /Title ( ) /Prev 385 0 R /Parent 343 0 R /Next 387 0 R >> endobj 387 0 obj << /Dest [5 0 R /XYZ 44 553 null] /Title ( ) /Prev 386 0 R /Parent 343 0 R /Next 388 0 R >> endobj 388 0 obj << /Dest [5 0 R /XYZ 72 539 null] /Title (Overview ) /Prev 387 0 R /Parent 343 0 R /Next 389 0 R >> endobj 389 0 obj << /Dest [5 0 R /XYZ 72 524 null] /Title ( ) /Prev 388 0 R /Parent 343 0 R /Next 390 0 R >> endobj 390 0 obj << /Dest [5 0 R /XYZ 72 510 null] /Title (911as founded in 1826 and was the first University to admit women and men on equal grounds without any discrimination based on religion. Since then, it has been hugely successful and consistently ranks among the top 20 Universities worldwide and it ranks within the top three in the UK with Cambridge and Oxford. UCL is the 10th most cited University overall \(Essential Science Indicators 2020 from Clarivate Analytics\) and is the top-rated UK university for research strength \(Research Excellence Framework 20) /Prev 389 0 R /Parent 343 0 R /Next 391 0 R >> endobj 391 0 obj << /Dest [5 0 R /XYZ 72 349 null] /Title ( ) /Prev 390 0 R /Parent 343 0 R /Next 392 0 R >> endobj 392 0 obj << /Dest [5 0 R /XYZ 72 334 null] /Title (The UCL Division of Infection & Immunity is part of the Faculty of Medical Sciences. In the last Research Assessment Exercise \(RAE 2014\), the Infection and Immunology panel graded 80% of outputs from the Division as 4* \(world leading\) or 3* \(internationally excellent\). The Division has state of the art facilities, including three level 3 containment laboratories and multi-parameter flow cytometry and has access to high content imaging, high throughput screening and next generation sequencing. ) /Prev 391 0 R /Parent 343 0 R /Next 393 0 R >> endobj 393 0 obj << /Dest [5 0 R /XYZ 72 250 null] /Title ( ) /Prev 392 0 R /Parent 343 0 R /Next 394 0 R >> endobj 400 0 obj << /Dest [5 0 R /XYZ 108 207 null] /Title (/immunity-transplantation) /Parent 399 0 R >> endobj 398 0 obj << /Dest [5 0 R /XYZ 90 207 null] /Title (\200 The UCL Institute of Immunity and Transplantation: ) /Parent 397 0 R /Next 399 0 R >> endobj 399 0 obj << /Count 1 /Dest [5 0 R /XYZ 0 842 null] /First 400 0 R /Last 400 0 R /Title (/immunity-transplantation) /Prev 398 0 R /Parent 397 0 R /Next 401 0 R >> endobj 401 0 obj << /Dest [5 0 R /XYZ 108 193 null] /Title ( ) /Prev 399 0 R /Parent 397 0 R >> endobj 397 0 obj << /Count 4 /Dest [5 0 R /XYZ 90 207 null] /First 398 0 R /Last 401 0 R /Title (\200 The UCL Institute of Immunity and Transplantation: ) /Parent 396 0 R >> endobj 406 0 obj << /Dest [5 0 R /XYZ 307 179 null] /Title (https://www.ahri.org/about/ ) /Parent 405 0 R >> endobj 404 0 obj << /Dest [5 0 R /XYZ 90 179 null] /Title (\200 The UCL Africa Health Research Institute: ) /Parent 403 0 R /Next 405 0 R >> endobj 405 0 obj << /Count 1 /Dest [5 0 R /XYZ 0 842 null] /First 406 0 R /Last 406 0 R /Title (https://www.ahri.org/about/ ) /Prev 404 0 R /Parent 403 0 R /Next 407 0 R >> endobj 407 0 obj << /Dest [5 0 R /XYZ 306 179 null] /Title ( ) /Prev 405 0 R /Parent 403 0 R >> endobj 403 0 obj << /Count 4 /Dest [5 0 R /XYZ 90 179 null] /First 404 0 R /Last 407 0 R /Title (\200 The UCL Africa Health Research Institute: ) /Parent 402 0 R >> endobj 396 0 obj << /Count 5 /Dest [5 0 R /XYZ 90 207 null] /First 397 0 R /Last 397 0 R /Title (\200 The UCL Institute of Immunity and Transplantation: ) /Parent 395 0 R /Next 402 0 R >> endobj 402 0 obj << /Count 5 /Dest [5 0 R /XYZ 90 179 null] /First 403 0 R /Last 403 0 R /Title (\200 The UCL Africa Health Research Institute: ) /Prev 396 0 R /Parent 395 0 R >> endobj 394 0 obj << /Dest [5 0 R /XYZ 72 236 null] /Title (The Division comprises the Department of Infection and the Department of Immunology and two Institutes: ) /Prev 393 0 R /Parent 343 0 R /Next 395 0 R >> endobj 395 0 obj << /Count 12 /Dest [5 0 R /XYZ 90 207 null] /First 396 0 R /Last 402 0 R /Title (\200 The UCL Institute of Immunity and Transplantation: ) /Prev 394 0 R /Parent 343 0 R /Next 408 0 R >> endobj 408 0 obj << /Dest [5 0 R /XYZ 72 163 null] /Title ( ) /Prev 395 0 R /Parent 343 0 R /Next 409 0 R >> endobj 409 0 obj << /Dest [5 0 R /XYZ 72 149 null] /Title (The Department of Infection focuses on pathogen biology \(HIV-1, Herpesviruses, hepatitis viruses mycobacterium tuberculosis, pneumococcus, SARS-CoV-2, transmissible cancers\) pathogens evolution, immune regulation by pathogens and translational medicine. ) /Prev 408 0 R /Parent 343 0 R /Next 410 0 R >> endobj 410 0 obj << /Dest [5 0 R /XYZ 72 107 null] /Title ( ) /Prev 409 0 R /Parent 343 0 R /Next 411 0 R >> endobj 411 0 obj << /Dest [5 0 R /XYZ 72 93 null] /Title (The Institute of Immunity and Transplantation \(IIT\) is based at the Royal Free campus in London and it is hosted in the new Pears building. The IIT focuses its research on transplantation and tissue ) /Prev 410 0 R /Parent 343 0 R /Next 412 0 R >> endobj 412 0 obj << /Dest [6 0 R /XYZ 72 783 null] /Title (engineering, vaccination, cell and gene therapy, chronic infection, autoimmunity, immunological therapy for cancer and inherited immunological diseases. ) /Prev 411 0 R /Parent 343 0 R /Next 413 0 R >> endobj 413 0 obj << /Dest [6 0 R /XYZ 72 755 null] /Title ( ) /Prev 412 0 R /Parent 343 0 R /Next 414 0 R >> endobj 414 0 obj << /Dest [6 0 R /XYZ 72 741 null] /Title (The UCL African Health Research Institute \(AHRI\), based in Durban, South Africa, is funded by the Wellcome Trust and focuses its research on global health problems such as HIV-1 and Tuberculosis, drug resistance, SARS-CoV-2, population surveillance, viral reservoirs and co-infections. ) /Prev 413 0 R /Parent 343 0 R /Next 415 0 R >> endobj 415 0 obj << /Dest [6 0 R /XYZ 72 685 null] /Title ( ) /Prev 414 0 R /Parent 343 0 R /Next 416 0 R >> endobj 416 0 obj << /Dest [6 0 R /XYZ 72 671 null] /Title (The Division of Infection and Immunity has strong links to UCL hospitals, which include University College Hospital \(UCH\), The Royal Free Hospital, Great Ormond Street Hospital for Children \(GOSH\), The National Hospital for Neurology and Neurosurgery, the Hospital for Tropical Diseases, the Moorfields Eye Hospital and other members of UCL Partners. Furthermore, the Division has a global reach through the AHRI and collaborative research programmes in Malawi. ) /Prev 415 0 R /Parent 343 0 R /Next 417 0 R >> endobj 417 0 obj << /Dest [6 0 R /XYZ 72 601 null] /Title ( ) /Prev 416 0 R /Parent 343 0 R /Next 418 0 R >> endobj 418 0 obj << /Dest [6 0 R /XYZ 44 586 null] /Title ( ) /Prev 417 0 R /Parent 343 0 R /Next 419 0 R >> endobj 419 0 obj << /Dest [6 0 R /XYZ 148 402 null] /Title ( ) /Prev 418 0 R /Parent 343 0 R /Next 420 0 R >> endobj 420 0 obj << /Dest [6 0 R /XYZ 148 574 null] /Title (Figure) /Prev 419 0 R /Parent 343 0 R /Next 421 0 R >> endobj 421 0 obj << /Dest [6 0 R /XYZ 150 387 null] /Title (The Cruciform building seen from the main UCL quad ) /Prev 420 0 R /Parent 343 0 R /Next 422 0 R >> endobj 422 0 obj << /Dest [6 0 R /XYZ 150 372 null] /Title ( ) /Prev 421 0 R /Parent 343 0 R /Next 423 0 R >> endobj 423 0 obj << /Dest [6 0 R /XYZ 150 358 null] /Title ( ) /Prev 422 0 R /Parent 343 0 R /Next 424 0 R >> endobj 424 0 obj << /Dest [6 0 R /XYZ 150 136 null] /Title ( ) /Prev 423 0 R /Parent 343 0 R /Next 425 0 R >> endobj 425 0 obj << /Dest [6 0 R /XYZ 150 345 null] /Title (Figure) /Prev 424 0 R /Parent 343 0 R /Next 426 0 R >> endobj 426 0 obj << /Dest [6 0 R /XYZ 150 122 null] /Title (The new Pears building at the Royal Free campus ) /Prev 425 0 R /Parent 343 0 R /Next 427 0 R >> endobj 427 0 obj << /Dest [6 0 R /XYZ 72 107 null] /Title ( ) /Prev 426 0 R /Parent 343 0 R /Next 428 0 R >> endobj 428 0 obj << /Dest [6 0 R /XYZ 72 92 null] /Title ( ) /Prev 427 0 R /Parent 343 0 R /Next 429 0 R >> endobj 429 0 obj << /Dest [6 0 R /XYZ 72 78 null] /Title ( ) /Prev 428 0 R /Parent 343 0 R /Next 430 0 R >> endobj 433 0 obj << /Dest [7 0 R /XYZ 90 768 null] /Title (\200 Teach our PhD students how to perform world-leading research into Infection & Immunity \(basic or translational\). ) /Parent 432 0 R >> endobj 435 0 obj << /Dest [7 0 R /XYZ 90 738 null] /Title (\200 Prepare them to become independent researchers. ) /Parent 434 0 R >> endobj 432 0 obj << /Count 1 /Dest [7 0 R /XYZ 90 768 null] /First 433 0 R /Last 433 0 R /Title (\200 Teach our PhD students how to perform world-leading research into Infection & Immunity \(basic or translational\). ) /Parent 431 0 R /Next 434 0 R >> endobj 437 0 obj << /Dest [7 0 R /XYZ 90 723 null] /Title (\200 Foster interdisciplinary research. ) /Parent 436 0 R >> endobj 434 0 obj << /Count 1 /Dest [7 0 R /XYZ 90 738 null] /First 435 0 R /Last 435 0 R /Title (\200 Prepare them to become independent researchers. ) /Prev 432 0 R /Parent 431 0 R /Next 436 0 R >> endobj 436 0 obj << /Count 1 /Dest [7 0 R /XYZ 90 723 null] /First 437 0 R /Last 437 0 R /Title (\200 Foster interdisciplinary research. ) /Prev 434 0 R /Parent 431 0 R >> endobj 430 0 obj << /Dest [7 0 R /XYZ 72 783 null] /Title (We aim to: ) /Prev 429 0 R /Parent 343 0 R /Next 431 0 R >> endobj 431 0 obj << /Count 6 /Dest [7 0 R /XYZ 90 768 null] /First 432 0 R /Last 436 0 R /Title (\200 Teach our PhD students how to perform world-leading research into Infection & Immunity \(basic or translational\). ) /Prev 430 0 R /Parent 343 0 R /Next 438 0 R >> endobj 438 0 obj << /Dest [7 0 R /XYZ 72 708 null] /Title ( ) /Prev 431 0 R /Parent 343 0 R /Next 439 0 R >> endobj 439 0 obj << /Dest [7 0 R /XYZ 72 693 null] /Title (We have selected primary supervisors intending to host a student on the basis of excellence of their research, quality of the projects and track record in supervising students. ) /Prev 438 0 R /Parent 343 0 R /Next 440 0 R >> endobj 440 0 obj << /Dest [7 0 R /XYZ 72 664 null] /Title (The Division of Infection & Immunity has been very successful in training PhD students. Over 60% of our students carry on with their career in academia at world leading Institutions, and another 22% enter the academic medical profession. ) /Prev 439 0 R /Parent 343 0 R /Next 441 0 R >> endobj 441 0 obj << /Dest [7 0 R /XYZ 72 620 null] /Title ( ) /Prev 440 0 R /Parent 343 0 R /Next 442 0 R >> endobj 442 0 obj << /Dest [7 0 R /XYZ 72 605 null] /Title ( ) /Prev 441 0 R /Parent 343 0 R /Next 443 0 R >> endobj 443 0 obj << /Dest [7 0 R /XYZ 72 591 null] /Title (Structure of the PhD ) /Prev 442 0 R /Parent 343 0 R /Next 444 0 R >> endobj 444 0 obj << /Dest [7 0 R /XYZ 72 576 null] /Title ( ) /Prev 443 0 R /Parent 343 0 R /Next 445 0 R >> endobj 445 0 obj << /Dest [7 0 R /XYZ 72 561 null] /Title (Each student will have a primary supervisor and a thesis committee, which will include a secondary supervisor \(acting as thesis committee chair\) and one or two faculty members who can provide guidance and insight over the duration of the project. The thesis committee will have an advisory role and will meet at regular intervals during the PhD. The thesis committee will foster intellectual exchange and collaborations between the student and faculty members as well as among faculty members based at the differ) /Prev 444 0 R /Parent 343 0 R /Next 446 0 R >> endobj 446 0 obj << /Dest [7 0 R /XYZ 72 477 null] /Title ( ) /Prev 445 0 R /Parent 343 0 R /Next 447 0 R >> endobj 447 0 obj << /Dest [7 0 R /XYZ 206 463 null] /Title (Students will have access to lectures and courses organized by the Division. Currently there are 21 courses covering Bacteriology, Virology, Parasitology, Mycology, Epidemiology, Immunology, Allergy and Immunodeficiency. Students will transfer \(upgrade\) from MPhil to PhD one and a half years after registration. Upgrade is conditional on satisfactory progress and the student will be required to present his/her research at a Divisional seminar, write a report and pass a viva examination. ) /Prev 446 0 R /Parent 343 0 R /Next 448 0 R >> endobj 448 0 obj << /Dest [7 0 R /XYZ 72 465 null] /Title (Figure) /Prev 447 0 R /Parent 343 0 R /Next 449 0 R >> endobj 449 0 obj << /Dest [7 0 R /XYZ 72 351 null] /Title ( ) /Prev 448 0 R /Parent 343 0 R /Next 450 0 R >> endobj 450 0 obj << /Dest [7 0 R /XYZ 72 336 null] /Title (Funding ) /Prev 449 0 R /Parent 343 0 R /Next 451 0 R >> endobj 455 0 obj << /Dest [7 0 R /XYZ 72 279 null] /Title (http://www.ucl.ac.uk/prospective-students/scholarships) /Parent 454 0 R >> endobj 453 0 obj << /Dest [7 0 R /XYZ 72 307 null] /Title (Please note that we are currently unable to offer studentships, however we welcome applications from individuals who have secured their own studentship or intend to apply for a studentship. Information on scholarships can be found here: ) /Parent 452 0 R /Next 454 0 R >> endobj 454 0 obj << /Count 1 /Dest [7 0 R /XYZ 0 842 null] /First 455 0 R /Last 455 0 R /Title (http://www.ucl.ac.uk/prospective-students/scholarships) /Prev 453 0 R /Parent 452 0 R /Next 456 0 R >> endobj 456 0 obj << /Dest [7 0 R /XYZ 72 265 null] /Title ( ) /Prev 454 0 R /Parent 452 0 R >> endobj 451 0 obj << /Dest [7 0 R /XYZ 72 322 null] /Title ( ) /Prev 450 0 R /Parent 343 0 R /Next 452 0 R >> endobj 452 0 obj << /Count 4 /Dest [7 0 R /XYZ 72 307 null] /First 453 0 R /Last 456 0 R /Title (Please note that we are currently unable to offer studentships, however we welcome applications from individuals who have secured their own studentship or intend to apply for a studentship. Information on scholarships can be found here: ) /Prev 451 0 R /Parent 343 0 R /Next 457 0 R >> endobj 461 0 obj << /Dest [7 0 R /XYZ 72 237 null] /Title (Birkbeck-UCL MRC Doctoral training programme) /Parent 460 0 R >> endobj 459 0 obj << /Dest [7 0 R /XYZ 72 237 null] /Title (UK nationals, EU citizens with settled status and overseas students may apply to the ) /Parent 458 0 R /Next 460 0 R >> endobj 460 0 obj << /Count 1 /Dest [7 0 R /XYZ 0 842 null] /First 461 0 R /Last 461 0 R /Title (Birkbeck-UCL MRC Doctoral training programme) /Prev 459 0 R /Parent 458 0 R /Next 462 0 R >> endobj 464 0 obj << /Dest [7 0 R /XYZ 76 181 null] /Title (https://opticalbiology.org/) /Parent 463 0 R >> endobj 462 0 obj << /Dest [7 0 R /XYZ 72 223 null] /Title ( within the themes of \215Fundamental mechanism of Disease\216 or \215Experimental and Personalised Medicine\216. Successful applicants will be able to take a PhD in the Division of Infection & Immunity. The Wellcome Trust PhD programme in Optical Biology \() /Prev 460 0 R /Parent 458 0 R /Next 463 0 R >> endobj 463 0 obj << /Count 1 /Dest [7 0 R /XYZ 0 842 null] /First 464 0 R /Last 464 0 R /Title (https://opticalbiology.org/) /Prev 462 0 R /Parent 458 0 R /Next 465 0 R >> endobj 465 0 obj << /Dest [7 0 R /XYZ 72 181 null] /Title (\) also has a number of supervisors based in the Division of Infection and Immunity. ) /Prev 463 0 R /Parent 458 0 R >> endobj 457 0 obj << /Dest [7 0 R /XYZ 72 251 null] /Title ( ) /Prev 452 0 R /Parent 343 0 R /Next 458 0 R >> endobj 458 0 obj << /Count 7 /Dest [7 0 R /XYZ 72 237 null] /First 459 0 R /Last 465 0 R /Title (UK nationals, EU citizens with settled status and overseas students may apply to the ) /Prev 457 0 R /Parent 343 0 R /Next 466 0 R >> endobj 466 0 obj << /Dest [7 0 R /XYZ 72 153 null] /Title ( ) /Prev 458 0 R /Parent 343 0 R /Next 467 0 R >> endobj 467 0 obj << /Dest [7 0 R /XYZ 72 139 null] /Title (Overseas students can apply to the MRC DTP programme and the Wellcome Trust Optical biology programme, which have a few overseas studentships available. Alternatively, they must obtain independent funding that covers tuition fees \24326,160 \(FT fee in 2021\) per year for 3 years subject to yearly increments plus living expenses. Funds to cover consumables for research are desirable but may not be necessary, depending on the supervisor. ) /Prev 466 0 R /Parent 343 0 R /Next 468 0 R >> endobj 468 0 obj << /Dest [7 0 R /XYZ 72 69 null] /Title ( ) /Prev 467 0 R /Parent 343 0 R /Next 469 0 R >> endobj 469 0 obj << /Dest [8 0 R /XYZ 72 783 null] /Title (Admission criteria and process ) /Prev 468 0 R /Parent 343 0 R /Next 470 0 R >> endobj 474 0 obj << /Dest [8 0 R /XYZ 169 698 null] /Title (http://www.ucl.ac.uk/prospective-students/international/countries) /Parent 473 0 R >> endobj 472 0 obj << /Dest [8 0 R /XYZ 72 754 null] /Title (Admission is competitive. Students must have obtained a First class degree or equivalent from a good Institution. Candidates with an Upper Second class \(2.1\) degree or equivalent can also apply but in this case the standing of the Institution awarding the degree will have more weigh, along with A-levels \(or equivalent\) results. Overseas students should look here for guidance on academic degree equivalence: ) /Parent 471 0 R /Next 473 0 R >> endobj 473 0 obj << /Count 1 /Dest [8 0 R /XYZ 0 842 null] /First 474 0 R /Last 474 0 R /Title (http://www.ucl.ac.uk/prospective-students/international/countries) /Prev 472 0 R /Parent 471 0 R /Next 475 0 R >> endobj 475 0 obj << /Dest [8 0 R /XYZ 169 698 null] /Title ( ) /Prev 473 0 R /Parent 471 0 R >> endobj 470 0 obj << /Dest [8 0 R /XYZ 72 768 null] /Title ( ) /Prev 469 0 R /Parent 343 0 R /Next 471 0 R >> endobj 471 0 obj << /Count 4 /Dest [8 0 R /XYZ 72 754 null] /First 472 0 R /Last 475 0 R /Title (Admission is competitive. Students must have obtained a First class degree or equivalent from a good Institution. 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You should provide a statement letter explaining which lab or labs you would like to join and why. Please try to be specific ) /Prev 490 0 R /Parent 343 0 R /Next 492 0 R >> endobj 492 0 obj << /Dest [8 0 R /XYZ 72 503 null] /Title ( ) /Prev 491 0 R /Parent 343 0 R /Next 493 0 R >> endobj 493 0 obj << /Dest [8 0 R /XYZ 72 489 null] /Title (Direct your queries to: Frances Collins \(f.collins@ucl.ac.uk\) or by telephone: +44 \(0\) 20 3987 2443. ) /Prev 492 0 R /Parent 343 0 R /Next 494 0 R >> endobj 494 0 obj << /Dest [8 0 R /XYZ 72 475 null] /Title ( ) /Prev 493 0 R /Parent 343 0 R /Next 495 0 R >> endobj 495 0 obj << /Dest [8 0 R /XYZ 72 461 null] /Title ( ) /Prev 494 0 R /Parent 343 0 R /Next 496 0 R >> endobj 496 0 obj << /Dest [8 0 R /XYZ 72 447 null] /Title (Seminars and events ) /Prev 495 0 R /Parent 343 0 R /Next 497 0 R >> endobj 497 0 obj << /Dest [8 0 R /XYZ 72 432 null] /Title ( ) /Prev 496 0 R /Parent 343 0 R /Next 498 0 R >> endobj 498 0 obj << /Dest [8 0 R /XYZ 65 417 null] /Title (Figure) /Prev 497 0 R /Parent 343 0 R /Next 499 0 R >> endobj 499 0 obj << /Dest [8 0 R /XYZ 248 417 null] /Title (Attending seminars and presentations is an important aspect of the PhD. UCL offers a large selection of seminars and events with invited speakers from top Institutions worldwide. Students are encouraged to attend such seminars that are relevant to their studies and their scientific interests. ) /Prev 498 0 R /Parent 343 0 R /Next 500 0 R >> endobj 500 0 obj << /Dest [8 0 R /XYZ 248 333 null] /Title ( ) /Prev 499 0 R /Parent 343 0 R /Next 501 0 R >> endobj 501 0 obj << /Dest [8 0 R /XYZ 72 319 null] /Title (The Division organizes weekly external and internal seminars in the fields of Infection \(Virology, Parasitology, Bacteriology\) and Immunology and students are expected to attend the external seminars and present their work at the internal seminars. ) /Prev 500 0 R /Parent 343 0 R /Next 502 0 R >> endobj 502 0 obj << /Dest [8 0 R /XYZ 72 263 null] /Title ( ) /Prev 501 0 R /Parent 343 0 R /Next 503 0 R >> endobj 503 0 obj << /Dest [8 0 R /XYZ 72 249 null] /Title (Every year a PhD Colloquium is held where all the PhD students in the Division present their research. Prizes for the two best presentations are awarded on the day. A prominent scientist is invited to address the students at the end of the day with a talk covering his/her scientific discoveries and career. ) /Prev 502 0 R /Parent 343 0 R /Next 504 0 R >> endobj 504 0 obj << /Dest [8 0 R /XYZ 72 193 null] /Title ( ) /Prev 503 0 R /Parent 343 0 R /Next 505 0 R >> endobj 505 0 obj << /Dest [8 0 R /XYZ 72 179 null] /Title (A Postgraduate/Postdoc Club is organized by students and postdoctoral fellows with the support of the programme Committee. The Club invites external speakers in different areas \(science, politics, media, industry, finance\). 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/Prev 515 0 R /Parent 343 0 R /Next 521 0 R >> endobj 521 0 obj << /Count 4 /Dest [9 0 R /XYZ 72 613 null] /First 522 0 R /Last 525 0 R /Title (UCL, through its Professional Development Programme, offers a vast choice of targeted courses for skills training, including communication skills, writing grant proposals, assertiveness, ethics etc. ) /Prev 520 0 R /Parent 343 0 R /Next 526 0 R >> endobj 530 0 obj << /Dest [9 0 R /XYZ 76 543 null] /Title (http://www.ucl.ac.uk/infection-immunity/wom_ath) /Parent 529 0 R >> endobj 528 0 obj << /Dest [9 0 R /XYZ 72 557 null] /Title (The Division of Infection & Immunity has been awarded a Silver Athena Swan Award \() /Parent 527 0 R /Next 529 0 R >> endobj 529 0 obj << /Count 1 /Dest [9 0 R /XYZ 0 842 null] /First 530 0 R /Last 530 0 R /Title (http://www.ucl.ac.uk/infection-immunity/wom_ath) /Prev 528 0 R /Parent 527 0 R /Next 531 0 R >> endobj 531 0 obj << /Dest [9 0 R /XYZ 72 543 null] /Title (\) and is committed to supporting women in science. ) /Prev 529 0 R /Parent 527 0 R >> endobj 526 0 obj << /Dest [9 0 R /XYZ 72 571 null] /Title ( ) /Prev 521 0 R /Parent 343 0 R /Next 527 0 R >> endobj 527 0 obj << /Count 4 /Dest [9 0 R /XYZ 72 557 null] /First 528 0 R /Last 531 0 R /Title (The Division of Infection & Immunity has been awarded a Silver Athena Swan Award \() /Prev 526 0 R /Parent 343 0 R /Next 532 0 R >> endobj 532 0 obj << /Dest [9 0 R /XYZ 72 515 null] /Title ( ) /Prev 527 0 R /Parent 343 0 R /Next 533 0 R >> endobj 536 0 obj << /Dest [9 0 R /XYZ 72 459 null] /Title (http://www.ucl.ac.uk/prospective-students/study-abroad-guide/life-at-ucl/leisure-social) /Parent 535 0 R >> endobj 535 0 obj << /Count 1 /Dest [9 0 R /XYZ 0 842 null] /First 536 0 R /Last 536 0 R /Title (http://www.ucl.ac.uk/prospective-students/study-abroad-guide/life-at-ucl/leisure-social) /Parent 534 0 R /Next 537 0 R >> endobj 537 0 obj << /Dest [9 0 R /XYZ 72 459 null] /Title ( ) /Prev 535 0 R /Parent 534 0 R >> endobj 533 0 obj << /Dest [9 0 R /XYZ 72 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0 842 null] /First 545 0 R /Last 550 0 R /Title (p.bonfanti@ucl.ac.uk) /Prev 543 0 R /Parent 343 0 R /Next 551 0 R >> endobj 554 0 obj << /Dest [10 0 R /XYZ 72 710 null] /Title (https://www.crick.ac.uk/research/labs/paola-bonfanti) /Parent 553 0 R >> endobj 553 0 obj << /Count 1 /Dest [10 0 R /XYZ 0 842 null] /First 554 0 R /Last 554 0 R /Title (https://www.crick.ac.uk/research/labs/paola-bonfanti) /Parent 552 0 R /Next 555 0 R >> endobj 555 0 obj << /Dest [10 0 R /XYZ 72 710 null] /Title ( ) /Prev 553 0 R /Parent 552 0 R >> endobj 551 0 obj << /Dest [10 0 R /XYZ 72 724 null] /Title ( ) /Prev 544 0 R /Parent 343 0 R /Next 552 0 R >> endobj 552 0 obj << /Count 3 /Dest [10 0 R /XYZ 0 842 null] /First 553 0 R /Last 555 0 R /Title (https://www.crick.ac.uk/research/labs/paola-bonfanti) /Prev 551 0 R /Parent 343 0 R /Next 556 0 R >> endobj 556 0 obj << /Dest [10 0 R /XYZ 72 695 null] /Title (Twitter: @BonfantiLab ) /Prev 552 0 R /Parent 343 0 R /Next 557 0 R >> endobj 557 0 obj << /Dest [10 0 R /XYZ 72 680 null] /Title ( ) /Prev 556 0 R /Parent 343 0 R /Next 558 0 R >> endobj 558 0 obj << /Dest [10 0 R /XYZ 72 666 null] /Title (Epithelial Stem Cell biology and Regenerative Medicine Lab ) /Prev 557 0 R /Parent 343 0 R /Next 559 0 R >> endobj 559 0 obj << /Dest [10 0 R /XYZ 72 651 null] /Title ( ) /Prev 558 0 R /Parent 343 0 R /Next 560 0 R >> endobj 560 0 obj << /Dest [10 0 R /XYZ 72 637 null] /Title (Our group research aims at understanding how epithelial organs such as thymus, oesophagus and pancreas develop, change with aging, and become susceptible to diseases. The lab is currently based at the Francis Crick Institute and projects are carried out accessing facilities at both UCL and Crick institutes. ) /Prev 559 0 R /Parent 343 0 R /Next 561 0 R >> endobj 561 0 obj << /Dest [10 0 R /XYZ 72 580 null] /Title ( ) /Prev 560 0 R /Parent 343 0 R /Next 562 0 R >> endobj 562 0 obj << /Dest [10 0 R /XYZ 72 566 null] /Title (The thymus controls the development of immune competence and tolerance, and its functional dissection and subsequent reconstruction with desired cell populations might provide powerful tools applicable to many medical conditions, including primary or acquired immune deficiencies. ) /Prev 561 0 R /Parent 343 0 R /Next 563 0 R >> endobj 563 0 obj << /Dest [10 0 R /XYZ 72 524 null] /Title ( ) /Prev 562 0 R /Parent 343 0 R /Next 564 0 R >> endobj 564 0 obj << /Dest [10 0 R /XYZ 72 510 null] /Title (Our work brings a multidisciplinary approach by combining stem cell biology, bioengineering technologies for organ reconstruction, microfluidics, next generation sequencing and molecular analysis of T cell development. The outcome of this work will set the basis for novel clinical protocols for organ transplantation and immunodeficiency disorders. ) /Prev 563 0 R /Parent 343 0 R /Next 565 0 R >> endobj 565 0 obj << /Dest [10 0 R /XYZ 72 454 null] /Title ( ) /Prev 564 0 R /Parent 343 0 R /Next 566 0 R >> endobj 566 0 obj << /Dest [10 0 R /XYZ 72 440 null] /Title (Potential PhD projects are interdisciplinary and address fundamental questions related to human thymus biology and T cell development, tolerance and development of translational approaches for congenital and acquired immune disorders. ) /Prev 565 0 R /Parent 343 0 R /Next 567 0 R >> endobj 567 0 obj << /Dest [10 0 R /XYZ 72 398 null] /Title ( ) /Prev 566 0 R /Parent 343 0 R /Next 568 0 R >> endobj 568 0 obj << /Dest [10 0 R /XYZ 72 383 null] /Title (Relevant publications ) /Prev 567 0 R /Parent 343 0 R /Next 569 0 R >> endobj 569 0 obj << /Dest [10 0 R /XYZ 72 368 null] /Title ( ) /Prev 568 0 R /Parent 343 0 R /Next 570 0 R >> endobj 570 0 obj << /Dest [10 0 R /XYZ 72 354 null] /Title (1.Campinoti, Gjinovci, Ragazzini et al. Reconstitution of a functional human thymus by postnatal progenitor cells and natural whole organ scaffolds. Nature Communications 2020, Dec 11:632 doi.org/10.1038/s41467-020-20082-7 - PMID: 33311516 ) /Prev 569 0 R /Parent 343 0 R /Next 571 0 R >> endobj 571 0 obj << /Dest [10 0 R /XYZ 72 311 null] /Title (2.Claudinot et al. Beyond Lineage Restriction: Tp63-Expressing Adult Epithelial Stem Cells Have Latent Hairy Skin Competence. Nature Communications 2020 Nov 6;11\(1\):5645. doi.org.10.1038/s41467-020-19485-3 - PMID: 33159086 ) /Prev 570 0 R /Parent 343 0 R /Next 572 0 R >> endobj 572 0 obj << /Dest [10 0 R /XYZ 72 269 null] /Title (3.Park et al. A cell atlas of human thymic development defines T cell repertoire formation. Science 2020 Feb 21;367\(6480\). ) /Prev 571 0 R /Parent 343 0 R /Next 573 0 R >> endobj 573 0 obj << /Dest [10 0 R /XYZ 72 241 null] /Title (4.Piccinini E and Bonfanti P. Disassembling and Reaggregating the Thymus: The Pros and Cons of Current Assays. Methods in Molecular Biology 2019;1899:129-142 ) /Prev 572 0 R /Parent 343 0 R /Next 574 0 R >> endobj 574 0 obj << /Dest [10 0 R /XYZ 72 213 null] /Title (5.Giobbe et al. Extracellular matrix hydrogel derived from decellularized tissues enables endoderm organoids culture. Nature Communications 2019 Dec 11;10\(1\):5658. ) /Prev 573 0 R /Parent 343 0 R /Next 575 0 R >> endobj 575 0 obj << /Dest [10 0 R /XYZ 72 185 null] /Title (6. Loukogeorgakis et al. In utero transplantation of in vitro expanded autologous amniotic fluid stem cells results in efficient long-term hematopoietic engraftment. Stem Cells 2019 doi:10.1002/stem.3039 ) /Prev 574 0 R /Parent 343 0 R /Next 576 0 R >> endobj 576 0 obj << /Dest [10 0 R /XYZ 72 143 null] /Title (7.Bonfanti et al. \215Hearts and Bones\216: The Ups and Downs of \215Plasticity\216 in Stem Cell Biology. ) /Prev 575 0 R /Parent 343 0 R /Next 577 0 R >> endobj 577 0 obj << /Dest [10 0 R /XYZ 72 129 null] /Title (EMBO Molecular Medicine. 2012 May;4\(5\):353-61. Review ) /Prev 576 0 R /Parent 343 0 R /Next 578 0 R >> endobj 578 0 obj << /Dest [10 0 R /XYZ 72 115 null] /Title (8. Bonfanti et al. Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells. Nature. 2010 Aug 19;466\(7309\):978-82 ) /Prev 577 0 R /Parent 343 0 R /Next 579 0 R >> endobj 579 0 obj << /Dest [11 0 R /XYZ 72 783 null] /Title (Prof Benny Chain ) /Prev 578 0 R /Parent 343 0 R /Next 580 0 R >> endobj 583 0 obj << /Dest [11 0 R /XYZ 72 768 null] /Title (b.chain@ucl.ac.uk) /Parent 582 0 R >> endobj 582 0 obj << /Count 1 /Dest [11 0 R /XYZ 0 842 null] /First 583 0 R /Last 583 0 R /Title (b.chain@ucl.ac.uk) /Parent 581 0 R /Next 584 0 R >> endobj 584 0 obj << /Dest [11 0 R /XYZ 72 768 null] /Title ( ) /Prev 582 0 R /Parent 581 0 R >> endobj 580 0 obj << /Dest [11 0 R /XYZ 399 777 null] /Title (Figure) /Prev 579 0 R /Parent 343 0 R /Next 581 0 R >> endobj 581 0 obj << /Count 3 /Dest [11 0 R /XYZ 0 842 null] /First 582 0 R /Last 584 0 R /Title (b.chain@ucl.ac.uk) /Prev 580 0 R /Parent 343 0 R /Next 585 0 R >> endobj 588 0 obj << /Dest [11 0 R /XYZ 72 739 null] /Title (/infection-immunity/people/professor-benny-chain) /Parent 587 0 R >> endobj 587 0 obj << /Count 1 /Dest [11 0 R /XYZ 0 842 null] /First 588 0 R /Last 588 0 R /Title (/infection-immunity/people/professor-benny-chain) /Parent 586 0 R /Next 589 0 R >> endobj 589 0 obj << /Dest [11 0 R /XYZ 72 724 null] /Title ( ) /Prev 587 0 R /Parent 586 0 R >> endobj 585 0 obj << /Dest [11 0 R /XYZ 72 754 null] /Title ( ) /Prev 581 0 R /Parent 343 0 R /Next 586 0 R >> endobj 586 0 obj << /Count 3 /Dest [11 0 R /XYZ 0 842 null] /First 587 0 R /Last 589 0 R /Title (/infection-immunity/people/professor-benny-chain) /Prev 585 0 R /Parent 343 0 R /Next 590 0 R >> endobj 590 0 obj << /Dest [11 0 R /XYZ 72 710 null] /Title ( ) /Prev 586 0 R /Parent 343 0 R /Next 591 0 R >> endobj 591 0 obj << /Dest [11 0 R /XYZ 72 695 null] /Title (Reading and understanding the T cell repertoire ) /Prev 590 0 R /Parent 343 0 R /Next 592 0 R >> endobj 592 0 obj << /Dest [11 0 R /XYZ 72 680 null] /Title ( ) /Prev 591 0 R /Parent 343 0 R /Next 593 0 R >> endobj 593 0 obj << /Dest [11 0 R /XYZ 72 666 null] /Title (The adaptive immune system is based on a unique molecular system which generates an enormous diversity of receptors on T and B lymphocytes, each with the potential to recognise a different molecular pattern, and hence stimulate a specific immune response to a particular pathogen. The size of the receptor diversity in every individual is estimated to be in the order of 109 \205 1010 different receptors. With the advent of massively parallel high throughput sequencing it has now become possible to analyse this r) /Prev 592 0 R /Parent 343 0 R /Next 594 0 R >> endobj 594 0 obj << /Dest [11 0 R /XYZ 72 497 null] /Title ( ) /Prev 593 0 R /Parent 343 0 R /Next 595 0 R >> endobj 595 0 obj << /Dest [11 0 R /XYZ 72 483 null] /Title (Potential PhD projects combine wet lab and computational training opportunities. The experimental data use high throughput sequencing to analyse repertoires from a range of clinical sample collections, which include samples from individuals with infectious disease \(tuberculosis, HIV and COVID-19\), autoimmunity, immunodeficiency, transplantation or cancer. Computational analysis focuses on developing ways to interrogate this data to understand the underlying biology. Specifically we develop methods to compar) /Prev 594 0 R /Parent 343 0 R /Next 596 0 R >> endobj 596 0 obj << /Dest [11 0 R /XYZ 72 343 null] /Title ( ) /Prev 595 0 R /Parent 343 0 R /Next 597 0 R >> endobj 597 0 obj << /Dest [11 0 R /XYZ 72 329 null] /Title (The projects will provide training in immunology, molecular biology and computational biology. The projects will therefore be positioned at the intersection between machine learning and high throughput genomic technologies, which is one of the fastest moving and most exciting areas of the biomedical sciences. ) /Prev 596 0 R /Parent 343 0 R /Next 598 0 R >> endobj 598 0 obj << /Dest [11 0 R /XYZ 72 273 null] /Title ( ) /Prev 597 0 R /Parent 343 0 R /Next 599 0 R >> endobj 603 0 obj << /Dest [11 0 R /XYZ 144 244 null] /Title (/infection-immunity/people/professor-benny-chain) /Parent 602 0 R >> endobj 601 0 obj << /Dest [11 0 R /XYZ 72 244 null] /Title (Benny Chain ) /Parent 600 0 R /Next 602 0 R >> endobj 602 0 obj << /Count 1 /Dest [11 0 R /XYZ 0 842 null] /First 603 0 R /Last 603 0 R /Title (/infection-immunity/people/professor-benny-chain) /Prev 601 0 R /Parent 600 0 R /Next 604 0 R >> endobj 604 0 obj << /Dest [11 0 R /XYZ 144 244 null] /Title ( ) /Prev 602 0 R /Parent 600 0 R >> endobj 599 0 obj << /Dest [11 0 R /XYZ 72 259 null] /Title (Website ) /Prev 598 0 R /Parent 343 0 R /Next 600 0 R >> endobj 608 0 obj << /Dest [11 0 R /XYZ 183 230 null] /Title (http://www0.cs.ucl.ac.uk/staff/J.Shawe-Taylor/) /Parent 607 0 R >> endobj 606 0 obj << /Dest [11 0 R /XYZ 72 230 null] /Title ( John Shawe-Taylor ) /Parent 605 0 R /Next 607 0 R >> endobj 607 0 obj << /Count 1 /Dest [11 0 R /XYZ 0 842 null] /First 608 0 R /Last 608 0 R /Title (http://www0.cs.ucl.ac.uk/staff/J.Shawe-Taylor/) /Prev 606 0 R /Parent 605 0 R /Next 609 0 R >> endobj 609 0 obj << /Dest [11 0 R /XYZ 182 230 null] /Title ( ) /Prev 607 0 R /Parent 605 0 R >> endobj 600 0 obj << /Count 4 /Dest [11 0 R /XYZ 72 244 null] /First 601 0 R /Last 604 0 R /Title (Benny Chain ) /Prev 599 0 R /Parent 343 0 R /Next 605 0 R >> endobj 605 0 obj << /Count 4 /Dest [11 0 R /XYZ 72 230 null] /First 606 0 R /Last 609 0 R /Title ( John Shawe-Taylor ) /Prev 600 0 R /Parent 343 0 R /Next 610 0 R >> endobj 610 0 obj << /Dest [11 0 R /XYZ 72 216 null] /Title ( ) /Prev 605 0 R /Parent 343 0 R /Next 611 0 R >> endobj 611 0 obj << /Dest [11 0 R /XYZ 72 202 null] /Title (1. Joshi K et al Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer. Nat Med. 2019 Oct;25\(10\):1549-1559. PMID: 32494063. ) /Prev 610 0 R /Parent 343 0 R /Next 612 0 R >> endobj 612 0 obj << /Dest [11 0 R /XYZ 72 176 null] /Title (2. Peacock T, Heather JM, Ronel T, Chain B. Decombinator V4 - an improved AIRR-compliant software package for T cell receptor sequence annotation. Bioinformatics. 2020 Aug 27:btaa758. doi: 10.1093/bioinformatics/btaa758. Epub ahead of print. PMID: 32853330. ) /Prev 611 0 R /Parent 343 0 R /Next 613 0 R >> endobj 613 0 obj << /Dest [11 0 R /XYZ 82 140 null] /Title (3. Sampson D, Yager TD, Fox B, Shallcross L, McHugh L, Seldon T, Rapisarda A, Hendriks RA, Brandon RB, Navalkar K, Simpson N, Stafford S, Gil E, Venturini C, Tsaliki E, Roe J, Chain B, Noursadeghi M. Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study. BMC Med. 2020 Jul 21;18\(1\):185. doi: 10.1186/s12916-020-01653-3. ) /Prev 612 0 R /Parent 343 0 R /Next 614 0 R >> endobj 614 0 obj << /Dest [12 0 R /XYZ 70 786 null] /Title (Dr Jennifer Cowan ) /Prev 613 0 R /Parent 343 0 R /Next 615 0 R >> endobj 618 0 obj << /Dest [12 0 R /XYZ 72 755 null] /Title (Jennifer.cowan@ucl.ac.uk) /Parent 617 0 R >> endobj 617 0 obj << /Count 1 /Dest [12 0 R /XYZ 0 842 null] /First 618 0 R /Last 618 0 R /Title (Jennifer.cowan@ucl.ac.uk) /Parent 616 0 R /Next 619 0 R >> endobj 619 0 obj << /Dest [12 0 R /XYZ 72 755 null] /Title ( ) /Prev 617 0 R /Parent 616 0 R >> endobj 615 0 obj << /Dest [12 0 R /XYZ 431 785 null] /Title (Figure) /Prev 614 0 R /Parent 343 0 R /Next 616 0 R >> endobj 623 0 obj << /Dest [12 0 R /XYZ 72 728 null] /Title (/infection-immunity/people/dr-jennifer-cowan) /Parent 622 0 R >> endobj 621 0 obj << /Dest [12 0 R /XYZ 70 729 null] /Title (Span) /Parent 620 0 R /Next 622 0 R >> endobj 622 0 obj << /Count 1 /Dest [12 0 R /XYZ 0 842 null] /First 623 0 R /Last 623 0 R /Title (/infection-immunity/people/dr-jennifer-cowan) /Prev 621 0 R /Parent 620 0 R /Next 624 0 R >> endobj 624 0 obj << /Dest [12 0 R /XYZ 72 728 null] /Title ( ) /Prev 622 0 R /Parent 620 0 R >> endobj 616 0 obj << /Count 3 /Dest [12 0 R /XYZ 0 842 null] /First 617 0 R /Last 619 0 R /Title (Jennifer.cowan@ucl.ac.uk) /Prev 615 0 R /Parent 343 0 R /Next 620 0 R >> endobj 620 0 obj << /Count 4 /Dest [12 0 R /XYZ 70 729 null] /First 621 0 R /Last 624 0 R /Title (P) /Prev 616 0 R /Parent 343 0 R /Next 625 0 R >> endobj 625 0 obj << /Dest [12 0 R /XYZ 72 701 null] /Title (Controlling thymus function to improve T-cell immunity in the aged. ) /Prev 620 0 R /Parent 343 0 R /Next 626 0 R >> endobj 626 0 obj << /Dest [12 0 R /XYZ 72 673 null] /Title (The thymus is essential for the development of T-cells. It progressively shrinks in size with age, and temporally involutes following many natural insults. This results in progressive deterioration of T-cell output, yet, it is unknown whether it causes dysregulated T-cell responses. The laboratory uses novel mouse models that experimentally enhance thymic size and consequently function to explore the contribution of thymic atrophy on T-cell dynamics and immune system function. ) /Prev 625 0 R /Parent 343 0 R /Next 627 0 R >> endobj 627 0 obj << /Dest [12 0 R /XYZ 70 577 null] /Title (T-cells play essential roles in immune responses. They are many different T-cell subsets, that have distinct functional programs and anatomical locations. Dysregulated T-cell development or maintenance results in diverse immunologically mediated diseases ranging from immunodeficiency to autoimmunity. Generation of T-cells occurs exclusively in the thymus, thus, this organ dictates the immunological competence of the host. However, T-cell development is not constant throughout life, and the thymus undergoes ) /Prev 626 0 R /Parent 343 0 R /Next 628 0 R >> endobj 628 0 obj << /Dest [12 0 R /XYZ 70 409 null] /Title (In the lab we have generated novel mouse models in which thymic involution can be prevented or reversed. As a PhD student, you would explore if restoring thymic function alters peripheral T-cell populations and consequently T-cell responses of aging hosts when immune challenged. Moreover, the project would explore the role of the thymic environment in orchestrating this involution process. This work aims to better understand the mechanisms underlying immune aging, so as to improve immune protection in aged ) /Prev 627 0 R /Parent 343 0 R /Next 629 0 R >> endobj 629 0 obj << /Dest [12 0 R /XYZ 70 311 null] /Title (Relevant publications ) /Prev 628 0 R /Parent 343 0 R /Next 630 0 R >> endobj 630 0 obj << /Dest [12 0 R /XYZ 70 283 null] /Title (Cowan JE et al, Postnatal Involution and Counter-Involution of the Thymus. Frontiers in Immunology. 2020 May 12. ) /Prev 629 0 R /Parent 343 0 R /Next 631 0 R >> endobj 631 0 obj << /Dest [12 0 R /XYZ 70 242 null] /Title (Cowan JE et al. Myc Controls A Distinct Transcriptional Program in Fetal Thymic Epithelial Cells That Determines Thymus Growth, Nature Communications. 2019 Dec 02. ) /Prev 630 0 R /Parent 343 0 R /Next 632 0 R >> endobj 632 0 obj << /Dest [12 0 R /XYZ 72 198 null] /Title (Rane S et al. Age is not just a number: Naive T cells increase their ability to persist in the circulation over time. PLoS Biol. 2018 Apr 11. ) /Prev 631 0 R /Parent 343 0 R /Next 633 0 R >> endobj 633 0 obj << /Dest [12 0 R /XYZ 72 171 null] /Title ( ) /Prev 632 0 R /Parent 343 0 R /Next 634 0 R >> endobj 634 0 obj << /Dest [12 0 R /XYZ 72 158 null] /Title ( ) /Prev 633 0 R /Parent 343 0 R /Next 635 0 R >> endobj 635 0 obj << /Dest [12 0 R /XYZ 72 134 null] /Title ( ) /Prev 634 0 R /Parent 343 0 R /Next 636 0 R >> endobj 636 0 obj << /Dest [13 0 R /XYZ 72 783 null] /Title (Prof Ariberto Fassati MD PhD ) /Prev 635 0 R /Parent 343 0 R /Next 637 0 R >> endobj 640 0 obj << /Dest [13 0 R /XYZ 72 759 null] /Title (a.fassati@ucl.ac.uk) /Parent 639 0 R >> endobj 639 0 obj << /Count 1 /Dest [13 0 R /XYZ 0 842 null] /First 640 0 R /Last 640 0 R /Title (a.fassati@ucl.ac.uk) /Parent 638 0 R /Next 641 0 R >> endobj 641 0 obj << /Dest [13 0 R /XYZ 72 759 null] /Title ( ) /Prev 639 0 R /Parent 638 0 R >> endobj 637 0 obj << /Dest [13 0 R /XYZ 410 785 null] /Title (Figure) /Prev 636 0 R /Parent 343 0 R /Next 638 0 R >> endobj 644 0 obj << /Dest [13 0 R /XYZ 72 735 null] /Title (/infection-immunity/people/professor-ariberto-fassati) /Parent 643 0 R >> endobj 643 0 obj << /Count 1 /Dest [13 0 R /XYZ 0 842 null] /First 644 0 R /Last 644 0 R /Title (/infection-immunity/people/professor-ariberto-fassati) /Parent 642 0 R /Next 645 0 R >> endobj 645 0 obj << /Dest [13 0 R /XYZ 72 721 null] /Title ( ) /Prev 643 0 R /Parent 642 0 R >> endobj 638 0 obj << /Count 3 /Dest [13 0 R /XYZ 0 842 null] /First 639 0 R /Last 641 0 R /Title (a.fassati@ucl.ac.uk) /Prev 637 0 R /Parent 343 0 R /Next 642 0 R >> endobj 642 0 obj << /Count 3 /Dest [13 0 R /XYZ 0 842 null] /First 643 0 R /Last 645 0 R /Title (/infection-immunity/people/professor-ariberto-fassati) /Prev 638 0 R /Parent 343 0 R /Next 646 0 R >> endobj 646 0 obj << /Dest [13 0 R /XYZ 72 697 null] /Title ( ) /Prev 642 0 R /Parent 343 0 R /Next 647 0 R >> endobj 647 0 obj << /Dest [13 0 R /XYZ 72 673 null] /Title (Project areas: Transmissible cancers and HIV-1 latency. ) /Prev 646 0 R /Parent 343 0 R /Next 648 0 R >> endobj 648 0 obj << /Dest [13 0 R /XYZ 72 659 null] /Title (We study two pathogens that have a remarkable ability to evade the immune system, namely HIV-1 and the canine transmissible venereal tumour \(CTVT\). Both of these pathogens can persist in a latent form. Curing HIV-1 infection will require eliminating the latent viral reservoir either by purging infected cells or by inducing a state of super-latency that mimics the repression of endogenous retroviruses in our genome. We have combined chemical biology and \215omics\216 approaches to understand the mechanisms control) /Prev 647 0 R /Parent 343 0 R /Next 649 0 R >> endobj 649 0 obj << /Dest [13 0 R /XYZ 72 476 null] /Title ( ) /Prev 648 0 R /Parent 343 0 R /Next 650 0 R >> endobj 650 0 obj << /Dest [13 0 R /XYZ 72 462 null] /Title (Some years ago, we demonstrated that CTVT is a cancer that transmits as a cellular parasite. CTVT escapes allorecognition when it transmits, irrespective of the dog\220s leukocyte antigen type, yet it can be rejected by the immune system when the drug vincristine is administered. Such an extreme bi-modal phenotype is most interesting because it may suggest ways to prevent transplant rejection, and ways to trigger rejection of human cancers. We have recently shown that vincristine triggers CTVT rejection by act) /Prev 649 0 R /Parent 343 0 R /Next 651 0 R >> endobj 655 0 obj << /Dest [13 0 R /XYZ 72 280 null] /Title (Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth) /Parent 654 0 R >> endobj 653 0 obj << /Dest [13 0 R /XYZ 72 322 null] /Title (Tomas Raul Wiche Salinas, Yuwei Zhang, Daniele Sarnello, Alexander Zhyvoloup, Laurence Raymond Marchand, Delphine Planas, Manivel Lodha, Debashree Chatterjee, Kasia Karwacz, Sally Oxenford, Jean-Pierre Routy, Heather Amrine-Madsen, Petronela Ancuta and Ariberto Fassati. ) /Parent 652 0 R /Next 654 0 R >> endobj 654 0 obj << /Count 1 /Dest [13 0 R /XYZ 0 842 null] /First 655 0 R /Last 655 0 R /Title (Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth) /Prev 653 0 R /Parent 652 0 R /Next 656 0 R >> endobj 656 0 obj << /Dest [13 0 R /XYZ 72 280 null] /Title (. bioRxiv 2021.03.27.435072 \(in press, Proc Natl Acad Sci U S A\) ) /Prev 654 0 R /Parent 652 0 R >> endobj 651 0 obj << /Dest [13 0 R /XYZ 72 336 null] /Title ( ) /Prev 650 0 R /Parent 343 0 R /Next 652 0 R >> endobj 652 0 obj << /Count 4 /Dest [13 0 R /XYZ 72 322 null] /First 653 0 R /Last 656 0 R /Title (Tomas Raul Wiche Salinas, Yuwei Zhang, Daniele Sarnello, Alexander Zhyvoloup, Laurence Raymond Marchand, Delphine Planas, Manivel Lodha, Debashree Chatterjee, Kasia Karwacz, Sally Oxenford, Jean-Pierre Routy, Heather Amrine-Madsen, Petronela Ancuta and Ariberto Fassati. ) /Prev 651 0 R /Parent 343 0 R /Next 657 0 R >> endobj 657 0 obj << /Dest [13 0 R /XYZ 72 252 null] /Title ( ) /Prev 652 0 R /Parent 343 0 R /Next 658 0 R >> endobj 658 0 obj << /Dest [13 0 R /XYZ 72 238 null] /Title (Anderson I, Low JS, Weston S, Weinberger M, Zhyvoloup A, Labokha AA, Corazza G, Kitson RA, Moody CJ, Marcello A, Fassati A. Heat shock protein 90 controls HIV-1 reactivation from latency. Proc Natl Acad Sci U S A. 2014 Ap 15;111\(15\):E1528-37 ) /Prev 657 0 R /Parent 343 0 R /Next 659 0 R >> endobj 659 0 obj << /Dest [13 0 R /XYZ 72 196 null] /Title ( ) /Prev 658 0 R /Parent 343 0 R /Next 660 0 R >> endobj 660 0 obj << /Dest [13 0 R /XYZ 72 181 null] /Title (Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA. Clonal origin and evolution of a transmissible cancer. Cell. 2006;126\(3\):477-87. ) /Prev 659 0 R /Parent 343 0 R /Next 661 0 R >> endobj 661 0 obj << /Dest [13 0 R /XYZ 72 153 null] /Title ( ) /Prev 660 0 R /Parent 343 0 R /Next 662 0 R >> endobj 662 0 obj << /Dest [13 0 R /XYZ 72 139 null] /Title (Frampton D, Schwenzer H, Marino G, Butcher LM, Pollara G, Kriston-Vizi J,..and Fassati, A. Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor. Cancer Cell. 2018;33\(4\):620-33 e6. ) /Prev 661 0 R /Parent 343 0 R /Next 663 0 R >> endobj 663 0 obj << /Dest [13 0 R /XYZ 72 97 null] /Title ( ) /Prev 662 0 R /Parent 343 0 R /Next 664 0 R >> endobj 664 0 obj << /Dest [13 0 R /XYZ 72 83 null] /Title ( ) /Prev 663 0 R /Parent 343 0 R /Next 665 0 R >> endobj 665 0 obj << /Dest [14 0 R /XYZ 72 783 null] /Title (Prof Richard Goldstein ) /Prev 664 0 R /Parent 343 0 R /Next 666 0 R >> endobj 666 0 obj << /Dest [14 0 R /XYZ 410 781 null] /Title (Figure) /Prev 665 0 R /Parent 343 0 R /Next 667 0 R >> endobj 670 0 obj << /Dest [14 0 R /XYZ 72 757 null] /Title (r.goldstein@ucl.ac.uk) /Parent 669 0 R >> endobj 669 0 obj << /Count 1 /Dest [14 0 R /XYZ 0 842 null] /First 670 0 R /Last 670 0 R /Title (r.goldstein@ucl.ac.uk) /Parent 668 0 R /Next 671 0 R >> endobj 671 0 obj << /Dest [14 0 R /XYZ 72 757 null] /Title ( ) /Prev 669 0 R /Parent 668 0 R >> endobj 667 0 obj << /Dest [14 0 R /XYZ 72 769 null] /Title ( ) /Prev 666 0 R /Parent 343 0 R /Next 668 0 R >> endobj 668 0 obj << /Count 3 /Dest [14 0 R /XYZ 0 842 null] /First 669 0 R /Last 671 0 R /Title (r.goldstein@ucl.ac.uk) /Prev 667 0 R /Parent 343 0 R /Next 672 0 R >> endobj 675 0 obj << /Dest [14 0 R /XYZ 72 738 null] /Title (/infection-immunity/people/professor-richard-goldstein) /Parent 674 0 R >> endobj 674 0 obj << /Count 1 /Dest [14 0 R /XYZ 0 842 null] /First 675 0 R /Last 675 0 R /Title (/infection-immunity/people/professor-richard-goldstein) /Parent 673 0 R /Next 676 0 R >> endobj 676 0 obj << /Dest [14 0 R /XYZ 72 724 null] /Title ( ) /Prev 674 0 R /Parent 673 0 R >> endobj 672 0 obj << /Dest [14 0 R /XYZ 72 745 null] /Title ( ) /Prev 668 0 R /Parent 343 0 R /Next 673 0 R >> endobj 673 0 obj << /Count 3 /Dest [14 0 R /XYZ 0 842 null] /First 674 0 R /Last 676 0 R /Title (/infection-immunity/people/professor-richard-goldstein) /Prev 672 0 R /Parent 343 0 R /Next 677 0 R >> endobj 677 0 obj << /Dest [14 0 R /XYZ 72 711 null] /Title ( ) /Prev 673 0 R /Parent 343 0 R /Next 678 0 R >> endobj 678 0 obj << /Dest [14 0 R /XYZ 72 696 null] /Title (Decoding the evolutionary record: What advanced models of sequence change can reveal about DNA, genes, and gene products ) /Prev 677 0 R /Parent 343 0 R /Next 679 0 R >> endobj 679 0 obj << /Dest [14 0 R /XYZ 44 670 null] /Title ( ) /Prev 678 0 R /Parent 343 0 R /Next 680 0 R >> endobj 680 0 obj << /Dest [14 0 R /XYZ 72 662 null] /Title (Nature has been performing ultra-high throughput in vivo site-directed mutagenesis studies for the past few billion years. The resulting evolutionary record contains a wealth of information about proteins, their structure, function, and physiological context, and how proteins adapt to changing circumstances. Unfortunately, standard phenomenological models used to analyse sequence change generally assume the effects we are most interested in - the variations of selection between different locations and at di) /Prev 679 0 R /Parent 343 0 R /Next 681 0 R >> endobj 681 0 obj << /Dest [14 0 R /XYZ 65 502 null] /Title ( ) /Prev 680 0 R /Parent 343 0 R /Next 682 0 R >> endobj 682 0 obj << /Dest [14 0 R /XYZ 72 495 null] /Title (Project: The analysis of selection on non-coding regions ) /Prev 681 0 R /Parent 343 0 R /Next 683 0 R >> endobj 683 0 obj << /Dest [14 0 R /XYZ 72 482 null] /Title ( ) /Prev 682 0 R /Parent 343 0 R /Next 684 0 R >> endobj 684 0 obj << /Dest [14 0 R /XYZ 72 475 null] /Title (Our entire genome, as well as that of all pathogens, is shaped by the process of molecular evolution. In particular, the nucleotide bases and amino acids found in different locations are sculpted by the constraints at those locations, constraints that arise from the function, structure, physiological role, and context at that site. Some important locations must preserve some important property such as size, charge, or hydrogen bonding location. Other locations need to change as the constraints on that site ) /Prev 683 0 R /Parent 343 0 R /Next 685 0 R >> endobj 685 0 obj << /Dest [14 0 R /XYZ 65 206 null] /Title ( ) /Prev 684 0 R /Parent 343 0 R /Next 686 0 R >> endobj 686 0 obj << /Dest [14 0 R /XYZ 72 193 null] /Title (Relevant papers: ) /Prev 685 0 R /Parent 343 0 R /Next 687 0 R >> endobj 687 0 obj << /Dest [14 0 R /XYZ 72 180 null] /Title ( ) /Prev 686 0 R /Parent 343 0 R /Next 688 0 R >> endobj 688 0 obj << /Dest [14 0 R /XYZ 72 166 null] /Title (Benjamin P. Blackburne, Alan J. Hay, and Richard A. Goldstein \(2008\), Changing patterns of selective pressure in Human Influenza H3, PLoS Pathogens, 4, e1000058, PMID: 18451985. ) /Prev 687 0 R /Parent 343 0 R /Next 689 0 R >> endobj 689 0 obj << /Dest [14 0 R /XYZ 72 147 null] /Title (Mario dos Reis, Alan J. Hay, and Richard A. Goldstein \(2009\), Using Non-Homogeneous Models of Nucleotide Substitution to Identify Host Shift Events: Application to the Origin of the 1918 \217Spanish\220 Influenza Pandemic Virus, J Mol Evol., 69 ,333-345, PMID: 19787384. ) /Prev 688 0 R /Parent 343 0 R /Next 690 0 R >> endobj 690 0 obj << /Dest [14 0 R /XYZ 72 127 null] /Title (Asif U. Tamuri, Mario dos Reis, Alan J. Hay, Richard A. Goldstein \(2009\). Identifying changes in selective constraints: Host shifts in influenza. PLoS Comput Biol., 5, e1000564, PMID: 19911053. ) /Prev 689 0 R /Parent 343 0 R /Next 691 0 R >> endobj 691 0 obj << /Dest [14 0 R /XYZ 72 108 null] /Title (Mario dos Reis, Asif U. Tamuri, Alan J. Hay, Richard A. Goldstein \(2011\). Charting the host adaptation of influenza viruses. Mol Biol Evol 28:1755-1767, PMID: 21109586. ) /Prev 690 0 R /Parent 343 0 R /Next 692 0 R >> endobj 692 0 obj << /Dest [14 0 R /XYZ 72 88 null] /Title (Asif U. Tamuri, Mario dos Reis, Richard A. Goldstein \(2012\). Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models, Genetics, 190:1101-1115, PMID: 22209901. ) /Prev 691 0 R /Parent 343 0 R /Next 693 0 R >> endobj 693 0 obj << /Dest [15 0 R /XYZ 72 783 null] /Title (Prof Robert Heyderman ) /Prev 692 0 R /Parent 343 0 R /Next 694 0 R >> endobj 697 0 obj << /Dest [15 0 R /XYZ 72 768 null] /Title (r.heyderman@ucl.ac.uk) /Parent 696 0 R >> endobj 696 0 obj << /Count 1 /Dest [15 0 R /XYZ 0 842 null] /First 697 0 R /Last 697 0 R /Title (r.heyderman@ucl.ac.uk) /Parent 695 0 R /Next 698 0 R >> endobj 698 0 obj << /Dest [15 0 R /XYZ 72 768 null] /Title ( ) /Prev 696 0 R /Parent 695 0 R >> endobj 694 0 obj << /Dest [15 0 R /XYZ 388 785 null] /Title (Figure) /Prev 693 0 R /Parent 343 0 R /Next 695 0 R >> endobj 695 0 obj << /Count 3 /Dest [15 0 R /XYZ 0 842 null] /First 696 0 R /Last 698 0 R /Title (r.heyderman@ucl.ac.uk) /Prev 694 0 R /Parent 343 0 R /Next 699 0 R >> endobj 702 0 obj << /Dest [15 0 R /XYZ 72 739 null] /Title (/infection-immunity/people/professor-robert-heyderman) /Parent 701 0 R >> endobj 701 0 obj << /Count 1 /Dest [15 0 R /XYZ 0 842 null] /First 702 0 R /Last 702 0 R /Title (/infection-immunity/people/professor-robert-heyderman) /Parent 700 0 R /Next 703 0 R >> endobj 703 0 obj << /Dest [15 0 R /XYZ 72 724 null] /Title ( ) /Prev 701 0 R /Parent 700 0 R >> endobj 699 0 obj << /Dest [15 0 R /XYZ 72 754 null] /Title ( ) /Prev 695 0 R /Parent 343 0 R /Next 700 0 R >> endobj 700 0 obj << /Count 3 /Dest [15 0 R /XYZ 0 842 null] /First 701 0 R /Last 703 0 R /Title (/infection-immunity/people/professor-robert-heyderman) /Prev 699 0 R /Parent 343 0 R /Next 704 0 R >> endobj 704 0 obj << /Dest [15 0 R /XYZ 72 710 null] /Title ( ) /Prev 700 0 R /Parent 343 0 R /Next 705 0 R >> endobj 705 0 obj << /Dest [15 0 R /XYZ 72 695 null] /Title (Microbial and immunological basis of infection by mucosal bacteria and viruses ) /Prev 704 0 R /Parent 343 0 R /Next 706 0 R >> endobj 706 0 obj << /Dest [15 0 R /XYZ 72 666 null] /Title ( ) /Prev 705 0 R /Parent 343 0 R /Next 707 0 R >> endobj 707 0 obj << /Dest [15 0 R /XYZ 72 653 null] /Title (The man focus of my work is the microbial and immunological basis of severe infection caused by bacterial and viral mucosal pathogens in the UK and Africa, and their prevention through vaccination. We have developed innovative human experimental infection approaches to understanding the early interactions between pathogens and their human host in pneumococcal, Group B streptococcus and COVID19 infection models. In particular, we have shown that contrary to current thinking, during commensal carriage, Strept) /Prev 706 0 R /Parent 343 0 R /Next 708 0 R >> endobj 708 0 obj << /Dest [15 0 R /XYZ 72 532 null] /Title ( ) /Prev 707 0 R /Parent 343 0 R /Next 709 0 R >> endobj 709 0 obj << /Dest [15 0 R /XYZ 72 518 null] /Title (Potential PhD project areas include: ) /Prev 708 0 R /Parent 343 0 R /Next 710 0 R >> endobj 713 0 obj << /Dest [15 0 R /XYZ 90 491 null] /Title (1\) The cellular and molecular basis of bacterial colonisation and transmission at the mucosal surface ) /Parent 712 0 R >> endobj 715 0 obj << /Dest [15 0 R /XYZ 90 465 null] /Title (2\) Shifts in the genomic and antimicrobial resistance profiles of Streptococcus pneumoniae following the introduction of conjugate-polysaccharide vaccine and large-scale antibiotic use. ) /Parent 714 0 R >> endobj 712 0 obj << /Count 1 /Dest [15 0 R /XYZ 90 491 null] /First 713 0 R /Last 713 0 R /Title (1\) The cellular and molecular basis of bacterial colonisation and transmission at the mucosal surface ) /Parent 711 0 R /Next 714 0 R >> endobj 717 0 obj << /Dest [15 0 R /XYZ 90 424 null] /Title (3\) The impact of vaccination on the immune control of SARS COV-2 in experimental human infection ) /Parent 716 0 R >> endobj 714 0 obj << /Count 1 /Dest [15 0 R /XYZ 90 465 null] /First 715 0 R /Last 715 0 R /Title (2\) Shifts in the genomic and antimicrobial resistance profiles of Streptococcus pneumoniae following the introduction of conjugate-polysaccharide vaccine and large-scale antibiotic use. ) /Prev 712 0 R /Parent 711 0 R /Next 716 0 R >> endobj 716 0 obj << /Count 1 /Dest [15 0 R /XYZ 90 424 null] /First 717 0 R /Last 717 0 R /Title (3\) The impact of vaccination on the immune control of SARS COV-2 in experimental human infection ) /Prev 714 0 R /Parent 711 0 R >> endobj 710 0 obj << /Dest [15 0 R /XYZ 72 505 null] /Title ( ) /Prev 709 0 R /Parent 343 0 R /Next 711 0 R >> endobj 711 0 obj << /Count 6 /Dest [15 0 R /XYZ 90 491 null] /First 712 0 R /Last 716 0 R /Title (1\) The cellular and molecular basis of bacterial colonisation and transmission at the mucosal surface ) /Prev 710 0 R /Parent 343 0 R /Next 718 0 R >> endobj 718 0 obj << /Dest [15 0 R /XYZ 72 397 null] /Title ( ) /Prev 711 0 R /Parent 343 0 R /Next 719 0 R >> endobj 719 0 obj << /Dest [15 0 R /XYZ 72 384 null] /Title (Projects will exploit state-of-the-art immunological, imaging and genome analysis and new evolutionary mathematical modelling approaches. Studentship will provide training in cell biology, immunology, bacterial genome analysis, infectious disease epidemiology and fundamental population genetics and phylogenetics. There will be an emphasis on ensuring that analyses undertaken are linked to relevant functional biological questions to improve the mechanistic understanding of pathogenesis and are of public heal) /Prev 718 0 R /Parent 343 0 R /Next 720 0 R >> endobj 720 0 obj << /Dest [15 0 R /XYZ 72 303 null] /Title ( ) /Prev 719 0 R /Parent 343 0 R /Next 721 0 R >> endobj 724 0 obj << /Dest [15 0 R /XYZ 72 277 null] /Title (1\) Weight CM, Venturini C, Pojar S, Jochems SP, Reine J, Nikolaou E, Solorzano C, Noursadeghi M, Brown JS, Ferreira DM, Heyderman RS. Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface. Nat Commun. 2019;10:3060 ) /Parent 723 0 R >> endobj 726 0 obj << /Dest [15 0 R /XYZ 72 244 null] /Title (2\) Gori A, Harrison OB, Mlia E, Nishihara Y, Chan JM, Msefula J, Mallewa M, Dube Q, Swarthout TD, Nobbs AH, Maiden MCJ, French N, Heyderman RS. Pan-GWAS of Streptococcus agalactiae Highlights Lineage-Specific Genes Associated with Virulence and Niche Adaptation. mBio. 2020;11:e00728-20. ) /Parent 725 0 R >> endobj 723 0 obj << /Count 1 /Dest [15 0 R /XYZ 72 277 null] /First 724 0 R /Last 724 0 R /Title (1\) Weight CM, Venturini C, Pojar S, Jochems SP, Reine J, Nikolaou E, Solorzano C, Noursadeghi M, Brown JS, Ferreira DM, Heyderman RS. Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface. Nat Commun. 2019;10:3060 ) /Parent 722 0 R /Next 725 0 R >> endobj 728 0 obj << /Dest [15 0 R /XYZ 72 211 null] /Title (3\) Kalizang'oma A, Chaguza C, Gori A, Davison C, Beleza S, Antonio M, Beall B, Goldblatt D, Kwambana-Adams B, Bentley SD, Heyderman RS. Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from Streptococcus mitis. Microb Genom. 2021 In press ) /Parent 727 0 R >> endobj 725 0 obj << /Count 1 /Dest [15 0 R /XYZ 72 244 null] /First 726 0 R /Last 726 0 R /Title (2\) Gori A, Harrison OB, Mlia E, Nishihara Y, Chan JM, Msefula J, Mallewa M, Dube Q, Swarthout TD, Nobbs AH, Maiden MCJ, French N, Heyderman RS. Pan-GWAS of Streptococcus agalactiae Highlights Lineage-Specific Genes Associated with Virulence and Niche Adaptation. mBio. 2020;11:e00728-20. ) /Prev 723 0 R /Parent 722 0 R /Next 727 0 R >> endobj 730 0 obj << /Dest [15 0 R /XYZ 72 178 null] /Title (4\) Bar-Zeev N, Swarthout TD, Everett DB, Alaerts M, Msefula J, Brown C, Bilima S, Mallewa J, King C, von Gottberg A, Verani JR, Whitney CG, Mwansambo C, Gordon SB, Cunliffe NA, French N, Heyderman RS, VacSurv Consortium. Impact and effectiveness of 13-valent pneumococcal conjugate vaccine on population incidence of vaccine and non-vaccine serotype invasive pneumococcal disease in Blantyre, Malawi, 2006-18: prospective observational time-series and case-control studies. Lancet Glob Health. 2021 Jul;9:e989-e9) /Parent 729 0 R >> endobj 727 0 obj << /Count 1 /Dest [15 0 R /XYZ 72 211 null] /First 728 0 R /Last 728 0 R /Title (3\) Kalizang'oma A, Chaguza C, Gori A, Davison C, Beleza S, Antonio M, Beall B, Goldblatt D, Kwambana-Adams B, Bentley SD, Heyderman RS. Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from Streptococcus mitis. Microb Genom. 2021 In press ) /Prev 725 0 R /Parent 722 0 R /Next 729 0 R >> endobj 732 0 obj << /Dest [15 0 R /XYZ 72 123 null] /Title (5\) Swarthout TD, Fronterre C, Lourenco J, Obolski U, Gori A, Bar-Zeev N, Everett D, Kamng'ona AW, Mwalukomo TS, Mataya AA, Mwansambo C, Banda M, Gupta S, Diggle P, French N, Heyderman RS. High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi. Nat Commun. 2020;11:2222. ) /Parent 731 0 R >> endobj 729 0 obj << /Count 1 /Dest [15 0 R /XYZ 72 178 null] /First 730 0 R /Last 730 0 R /Title (4\) Bar-Zeev N, Swarthout TD, Everett DB, Alaerts M, Msefula J, Brown C, Bilima S, Mallewa J, King C, von Gottberg A, Verani JR, Whitney CG, Mwansambo C, Gordon SB, Cunliffe NA, French N, Heyderman RS, VacSurv Consortium. Impact and effectiveness of 13-valent pneumococcal conjugate vaccine on population incidence of vaccine and non-vaccine serotype invasive pneumococcal disease in Blantyre, Malawi, 2006-18: prospective observational time-series and case-control studies. Lancet Glob Health. 2021 Jul;9:e989-e9) /Prev 727 0 R /Parent 722 0 R /Next 731 0 R >> endobj 731 0 obj << /Count 1 /Dest [15 0 R /XYZ 72 123 null] /First 732 0 R /Last 732 0 R /Title (5\) Swarthout TD, Fronterre C, Lourenco J, Obolski U, Gori A, Bar-Zeev N, Everett D, Kamng'ona AW, Mwalukomo TS, Mataya AA, Mwansambo C, Banda M, Gupta S, Diggle P, French N, Heyderman RS. High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi. Nat Commun. 2020;11:2222. ) /Prev 729 0 R /Parent 722 0 R >> endobj 721 0 obj << /Dest [15 0 R /XYZ 72 290 null] /Title (Selected references: ) /Prev 720 0 R /Parent 343 0 R /Next 722 0 R >> endobj 722 0 obj << /Count 10 /Dest [15 0 R /XYZ 72 277 null] /First 723 0 R /Last 731 0 R /Title (1\) Weight CM, Venturini C, Pojar S, Jochems SP, Reine J, Nikolaou E, Solorzano C, Noursadeghi M, Brown JS, Ferreira DM, Heyderman RS. Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface. Nat Commun. 2019;10:3060 ) /Prev 721 0 R /Parent 343 0 R /Next 733 0 R >> endobj 733 0 obj << /Dest [15 0 R /XYZ 72 79 null] /Title ( ) /Prev 722 0 R /Parent 343 0 R /Next 734 0 R >> endobj 734 0 obj << /Dest [16 0 R /XYZ 72 783 null] /Title (Professor Clare Jolly ) /Prev 733 0 R /Parent 343 0 R /Next 735 0 R >> endobj 738 0 obj << /Dest [16 0 R /XYZ 72 768 null] /Title (c.jolly@ucl.ac.uk) /Parent 737 0 R >> endobj 737 0 obj << /Count 1 /Dest [16 0 R /XYZ 0 842 null] /First 738 0 R /Last 738 0 R /Title (c.jolly@ucl.ac.uk) /Parent 736 0 R /Next 739 0 R >> endobj 739 0 obj << /Dest [16 0 R /XYZ 72 768 null] /Title ( ) /Prev 737 0 R /Parent 736 0 R >> endobj 735 0 obj << /Dest [16 0 R /XYZ 426 785 null] /Title (Figure) /Prev 734 0 R /Parent 343 0 R /Next 736 0 R >> endobj 742 0 obj << /Dest [16 0 R /XYZ 72 754 null] /Title (/infection-immunity/people/dr-clare-jolly) /Parent 741 0 R >> endobj 741 0 obj << /Count 1 /Dest [16 0 R /XYZ 0 842 null] /First 742 0 R /Last 742 0 R /Title (/infection-immunity/people/dr-clare-jolly) /Parent 740 0 R /Next 743 0 R >> endobj 743 0 obj << /Dest [16 0 R /XYZ 72 754 null] /Title ( ) /Prev 741 0 R /Parent 740 0 R >> endobj 736 0 obj << /Count 3 /Dest [16 0 R /XYZ 0 842 null] /First 737 0 R /Last 739 0 R /Title (c.jolly@ucl.ac.uk) /Prev 735 0 R /Parent 343 0 R /Next 740 0 R >> endobj 746 0 obj << /Dest [16 0 R /XYZ 72 739 null] /Title (/jolly-lab/) /Parent 745 0 R >> endobj 745 0 obj << /Count 1 /Dest [16 0 R /XYZ 0 842 null] /First 746 0 R /Last 746 0 R /Title (/jolly-lab/) /Parent 744 0 R /Next 747 0 R >> endobj 747 0 obj << /Dest [16 0 R /XYZ 72 739 null] /Title ( ) /Prev 745 0 R /Parent 744 0 R >> endobj 740 0 obj << /Count 3 /Dest [16 0 R /XYZ 0 842 null] /First 741 0 R /Last 743 0 R /Title (/infection-immunity/people/dr-clare-jolly) /Prev 736 0 R /Parent 343 0 R /Next 744 0 R >> endobj 744 0 obj << /Count 3 /Dest [16 0 R /XYZ 0 842 null] /First 745 0 R /Last 747 0 R /Title (/jolly-lab/) /Prev 740 0 R /Parent 343 0 R /Next 748 0 R >> endobj 748 0 obj << /Dest [16 0 R /XYZ 72 727 null] /Title (twitter @Jolly_lab ) /Prev 744 0 R /Parent 343 0 R /Next 749 0 R >> endobj 749 0 obj << /Dest [16 0 R /XYZ 72 705 null] /Title ( ) /Prev 748 0 R /Parent 343 0 R /Next 750 0 R >> endobj 750 0 obj << /Dest [16 0 R /XYZ 72 691 null] /Title (My lab studies the interaction between HIV and CD4+ T cells. We seek to understand how HIV manipulates T cells to support viral replication and spread, and the consequences of this for the virus and the host. We are also applying our expertise in viral cell biology to dissect mechanisms of SARS-CoV-2 replication and spread between cells, and adaptation of SARS-CoV-2 to host focussing on innate immunity. ) /Prev 749 0 R /Parent 343 0 R /Next 751 0 R >> endobj 751 0 obj << /Dest [16 0 R /XYZ 72 620 null] /Title (Cell-to-cell spread is the dominant mode of HIV dissemination and takes place at immune cell contacts called virological synapses \(VS\). This confers a many of advantages for the virus including rapid infection of target cells, evasion of components of the innate and adaptive immunity and increased resistance to some antiretrovirals. Therefore cell-cell spread poses a considerable barrier to eradicating HIV from infected individuals. We seek to understand how this process works at the molecular level and to ) /Prev 750 0 R /Parent 343 0 R /Next 752 0 R >> endobj 752 0 obj << /Dest [16 0 R /XYZ 72 424 null] /Title (The overall goal of our research is understand the interaction between viruses and their hosts. To do this we use range of experimental techniques and approaches including \(but not limited to\) tissue culture, virological and immunological assays, molecular biology, mutagenesis and genetic manipulation of viruses and cells, advanced imaging approaches and multicolour flow cytometry. ) /Prev 751 0 R /Parent 343 0 R /Next 753 0 R >> endobj 753 0 obj << /Dest [16 0 R /XYZ 72 354 null] /Title (PhD projects are available to work on any aspect of the above areas of research on HIV and SARS-CoV-2. My lab currently consists of 3 post-doctoral scientists and 1 PhD student and funded by the Wellcome Trust. We regularly host MSc and iBSc project students and are an interactive lab that collaborates with many other groups around UCL and beyond. ) /Prev 752 0 R /Parent 343 0 R /Next 754 0 R >> endobj 754 0 obj << /Dest [16 0 R /XYZ 72 297 null] /Title ( ) /Prev 753 0 R /Parent 343 0 R /Next 755 0 R >> endobj 761 0 obj << /Dest [16 0 R /XYZ 93 269 null] /Title (HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells) /Parent 760 0 R >> endobj 759 0 obj << /Dest [16 0 R /XYZ 72 269 null] /Title (1 Reuschl A-K. et al., ) /Parent 758 0 R /Next 760 0 R >> endobj 760 0 obj << /Count 1 /Dest [16 0 R /XYZ 0 842 null] /First 761 0 R /Last 761 0 R /Title (HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells) /Prev 759 0 R /Parent 758 0 R /Next 762 0 R >> endobj 764 0 obj << /Dest [16 0 R /XYZ 280 256 null] /Title (https://doi.org/10.1101/2021.01.25.428084) /Parent 763 0 R >> endobj 762 0 obj << /Dest [16 0 R /XYZ 206 256 null] /Title (. \(2021\) BioRxiv ) /Prev 760 0 R /Parent 758 0 R /Next 763 0 R >> endobj 763 0 obj << /Count 1 /Dest [16 0 R /XYZ 0 842 null] /First 764 0 R /Last 764 0 R /Title (https://doi.org/10.1101/2021.01.25.428084) /Prev 762 0 R /Parent 758 0 R /Next 765 0 R >> endobj 765 0 obj << /Dest [16 0 R /XYZ 477 256 null] /Title ( ) /Prev 763 0 R /Parent 758 0 R >> endobj 758 0 obj << /Count 7 /Dest [16 0 R /XYZ 72 269 null] /First 759 0 R /Last 765 0 R /Title (1 Reuschl A-K. et al., ) /Parent 757 0 R >> endobj 767 0 obj << /Dest [16 0 R /XYZ 72 243 null] /Title (2 Mesner D. et al., \(2020\) Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread, Proc Natl Acad Sci USA 117: 7382-7391. ) /Parent 766 0 R >> endobj 757 0 obj << /Count 8 /Dest [16 0 R /XYZ 72 269 null] /First 758 0 R /Last 758 0 R /Title (1 Reuschl A-K. et al., ) /Parent 756 0 R /Next 766 0 R >> endobj 769 0 obj << /Dest [16 0 R /XYZ 72 216 null] /Title (3 Haider T. et al., HIV envelope truncation confers resistance to SERINC5 restriction \(2021\). Proceeding of the National Academy of Sciences USA 118: e2101450118. ) /Parent 768 0 R >> endobj 766 0 obj << /Count 1 /Dest [16 0 R /XYZ 72 243 null] /First 767 0 R /Last 767 0 R /Title (2 Mesner D. et al., \(2020\) Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread, Proc Natl Acad Sci USA 117: 7382-7391. ) /Prev 757 0 R /Parent 756 0 R /Next 768 0 R >> endobj 771 0 obj << /Dest [16 0 R /XYZ 72 189 null] /Title (4 Len AC. Et al., \(2017\) HIV-1 activates signaling independently of antigen to drive viral spread. Cell Reports 18: 1062-1074. ) /Parent 770 0 R >> endobj 768 0 obj << /Count 1 /Dest [16 0 R /XYZ 72 216 null] /First 769 0 R /Last 769 0 R /Title (3 Haider T. et al., HIV envelope truncation confers resistance to SERINC5 restriction \(2021\). Proceeding of the National Academy of Sciences USA 118: e2101450118. ) /Prev 766 0 R /Parent 756 0 R /Next 770 0 R >> endobj 776 0 obj << /Dest [16 0 R /XYZ 93 162 null] /Title (Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.) /Parent 775 0 R >> endobj 774 0 obj << /Dest [16 0 R /XYZ 72 162 null] /Title (5 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, et al., ) /Parent 773 0 R /Next 775 0 R >> endobj 775 0 obj << /Count 1 /Dest [16 0 R /XYZ 0 842 null] /First 776 0 R /Last 776 0 R /Title (Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.) /Prev 774 0 R /Parent 773 0 R /Next 777 0 R >> endobj 777 0 obj << /Dest [16 0 R /XYZ 93 149 null] /Title ( \(2021\) bioRxiv. Jun 7:2021.06.06.446826. doi: 10.1101/2021.06.06.446826. Preprint. ) /Prev 775 0 R /Parent 773 0 R >> endobj 773 0 obj << /Count 4 /Dest [16 0 R /XYZ 72 162 null] /First 774 0 R /Last 777 0 R /Title (5 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, et al., ) /Parent 772 0 R >> endobj 770 0 obj << /Count 1 /Dest [16 0 R /XYZ 72 189 null] /First 771 0 R /Last 771 0 R /Title (4 Len AC. Et al., \(2017\) HIV-1 activates signaling independently of antigen to drive viral spread. Cell Reports 18: 1062-1074. ) /Prev 768 0 R /Parent 756 0 R /Next 772 0 R >> endobj 779 0 obj << /Dest [16 0 R /XYZ 72 122 null] /Title (6 Thorne L.G., Reuschl A-K., Zuiliani-Alvarez L. et al. SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation. \(2021\) EMBO J 40 \(15\): e107826 ) /Parent 778 0 R >> endobj 772 0 obj << /Count 5 /Dest [16 0 R /XYZ 72 162 null] /First 773 0 R /Last 773 0 R /Title (5 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, et al., ) /Prev 770 0 R /Parent 756 0 R /Next 778 0 R >> endobj 778 0 obj << /Count 1 /Dest [16 0 R /XYZ 72 122 null] /First 779 0 R /Last 779 0 R /Title (6 Thorne L.G., Reuschl A-K., Zuiliani-Alvarez L. et al. SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation. \(2021\) EMBO J 40 \(15\): e107826 ) /Prev 772 0 R /Parent 756 0 R >> endobj 755 0 obj << /Dest [16 0 R /XYZ 72 283 null] /Title (Selected recent publication: ) /Prev 754 0 R /Parent 343 0 R /Next 756 0 R >> endobj 756 0 obj << /Count 23 /Dest [16 0 R /XYZ 72 269 null] /First 757 0 R /Last 778 0 R /Title (1 Reuschl A-K. et al., ) /Prev 755 0 R /Parent 343 0 R /Next 780 0 R >> endobj 780 0 obj << /Dest [16 0 R /XYZ 72 95 null] /Title ( ) /Prev 756 0 R /Parent 343 0 R /Next 781 0 R >> endobj 781 0 obj << /Dest [16 0 R /XYZ 72 80 null] /Title ( ) /Prev 780 0 R /Parent 343 0 R /Next 782 0 R >> endobj 782 0 obj << /Dest [17 0 R /XYZ 72 783 null] /Title (Professor Steve Ley ) /Prev 781 0 R /Parent 343 0 R /Next 783 0 R >> endobj 786 0 obj << /Dest [17 0 R /XYZ 72 768 null] /Title (steven.ley@ucl.ac.uk) /Parent 785 0 R >> endobj 785 0 obj << /Count 1 /Dest [17 0 R /XYZ 0 842 null] /First 786 0 R /Last 786 0 R /Title (steven.ley@ucl.ac.uk) /Parent 784 0 R /Next 787 0 R >> endobj 787 0 obj << /Dest [17 0 R /XYZ 72 768 null] /Title ( ) /Prev 785 0 R /Parent 784 0 R >> endobj 783 0 obj << /Dest [17 0 R /XYZ 395 784 null] /Title (Figure) /Prev 782 0 R /Parent 343 0 R /Next 784 0 R >> endobj 784 0 obj << /Count 3 /Dest [17 0 R /XYZ 0 842 null] /First 785 0 R /Last 787 0 R /Title (steven.ley@ucl.ac.uk) /Prev 783 0 R /Parent 343 0 R /Next 788 0 R >> endobj 788 0 obj << /Dest [17 0 R /XYZ 72 754 null] /Title ( ) /Prev 784 0 R /Parent 343 0 R /Next 789 0 R >> endobj 789 0 obj << /Dest [17 0 R /XYZ 72 742 null] /Title (Following infection, pathogenic bacteria trigger defensive Toll-like receptors \(TLRs\) on macrophages to activate mitogenactivated protein kinases \(MAPKs\), which control the expression of cytokines and chemokines that are essential for development of immunity to pathogens. TLR activation of the ERK1/2 and p38a MAP kinases in macrophages is mediated via Tumour Progression Locus 2 \(TPL-2; MAP3K8\), a MAP 3-kinase. TPL-2 is critical for inflammatory immune responses to bacteria, fungi and viruses \(1, 2\). My labo) /Prev 788 0 R /Parent 343 0 R /Next 790 0 R >> endobj 790 0 obj << /Dest [17 0 R /XYZ 72 602 null] /Title ( ) /Prev 789 0 R /Parent 343 0 R /Next 791 0 R >> endobj 791 0 obj << /Dest [17 0 R /XYZ 72 588 null] /Title (Our current areas of interest include: ) /Prev 790 0 R /Parent 343 0 R /Next 792 0 R >> endobj 792 0 obj << /Dest [17 0 R /XYZ 370 589 null] /Title (Figure) /Prev 791 0 R /Parent 343 0 R /Next 793 0 R >> endobj 793 0 obj << /Dest [17 0 R /XYZ 72 574 null] /Title (TPL-2 regulation of innate immune responses to pathogenic bacteria. A key early step in innate immune responses to pathogenic bacteria is the killing of phagocytosed bacteria by macrophages. This involves a process called phagosome maturation, in which internalised bacteria are trafficked into a series of increasingly acidified embrane-bound vacuoles and then degraded. Recent research by the Ley laboratory has shown that TPL-2 complex stimulates phagosome maturation independently of its established functio) /Prev 792 0 R /Parent 343 0 R /Next 794 0 R >> endobj 794 0 obj << /Dest [17 0 R /XYZ 72 419 null] /Title ( ) /Prev 793 0 R /Parent 343 0 R /Next 795 0 R >> endobj 795 0 obj << /Dest [17 0 R /XYZ 72 405 null] /Title (Employing in vitro and in vivo model systems, this will focus on two pathogenic bacterial species : ) /Prev 794 0 R /Parent 343 0 R /Next 796 0 R >> endobj 796 0 obj << /Dest [17 0 R /XYZ 72 392 null] /Title ( ) /Prev 795 0 R /Parent 343 0 R /Next 797 0 R >> endobj 797 0 obj << /Dest [17 0 R /XYZ 72 385 null] /Title (\200 Staphylococcus aureus, an extracellular Gram-positive bacterium that is the common cause of pneumonia and ) /Prev 796 0 R /Parent 343 0 R /Next 798 0 R >> endobj 798 0 obj << /Dest [17 0 R /XYZ 72 357 null] /Title (the pathogen most frequently linked to health care associated pneumonia. ) /Prev 797 0 R /Parent 343 0 R /Next 799 0 R >> endobj 799 0 obj << /Dest [17 0 R /XYZ 72 344 null] /Title ( ) /Prev 798 0 R /Parent 343 0 R /Next 800 0 R >> endobj 800 0 obj << /Dest [17 0 R /XYZ 72 337 null] /Title (\200 Salmonella typhimurium, a Gram-negative pathogen that causes both gastrointestinal and systemic diseases. ) /Prev 799 0 R /Parent 343 0 R /Next 801 0 R >> endobj 801 0 obj << /Dest [17 0 R /XYZ 72 309 null] /Title (TPL-2 regulation of cell survival following HCMV infection. Viruses have proven excellent tools to probe signalling ) /Prev 800 0 R /Parent 343 0 R /Next 802 0 R >> endobj 802 0 obj << /Dest [17 0 R /XYZ 72 281 null] /Title (pathways regulating key aspects of cell biology. Our unpublished data suggests that human cytomegalovirus \(HCMV\) ) /Prev 801 0 R /Parent 343 0 R /Next 803 0 R >> endobj 803 0 obj << /Dest [17 0 R /XYZ 72 253 null] /Title (activates TPL-2- ERK1/2 MAP kinase signalling pathway to establish latency in myeloid cells. In collaboration with the ) /Prev 802 0 R /Parent 343 0 R /Next 804 0 R >> endobj 804 0 obj << /Dest [17 0 R /XYZ 72 225 null] /Title (laboratory of Matthew Reeves \(/infection-immunity/people/dr-matthew-reeves\), one PhD project will investigate the mechanisms by which HCMV stimulates plasma membrane and endosomal TLR receptors to activate TPL-2 and the downstream consequences of TPL-2 signalling for HCMV infection. ) /Prev 803 0 R /Parent 343 0 R /Next 805 0 R >> endobj 805 0 obj << /Dest [17 0 R /XYZ 72 169 null] /Title ( ) /Prev 804 0 R /Parent 343 0 R /Next 806 0 R >> endobj 806 0 obj << /Dest [17 0 R /XYZ 72 157 null] /Title (References ) /Prev 805 0 R /Parent 343 0 R /Next 807 0 R >> endobj 807 0 obj << /Dest [17 0 R /XYZ 72 145 null] /Title /Prev 806 0 R /Parent 343 0 R /Next 808 0 R >> endobj 808 0 obj << /Dest [17 0 R /XYZ 72 122 null] /Title (2. Pattison MJ, Mitchell O, Flynn HR, Chen C-S, Yang H-T, Ben-Addi A, et al. TLR and TNFR1 activation of the MKK3/MKK6- p38alpha axis in macrophages is mediated by TPL-2 kinase. Biochem J. 2016;473:2845 - 61. ) /Prev 807 0 R /Parent 343 0 R /Next 809 0 R >> endobj 809 0 obj << /Dest [17 0 R /XYZ 72 99 null] /Title (3. Arthur JSC, Ley SC. Mitogen-activated protein kinases in innate immunity. Nature Rev Immunol. 2013;13:679 - 92. ) /Prev 808 0 R /Parent 343 0 R /Next 810 0 R >> endobj 810 0 obj << /Dest [17 0 R /XYZ 72 88 null] /Title (4. Breyer F, Hartlova A, Thurston T, Flynn HR, Chakravarty P, Janzen J, et al. TPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria. EMBO J. 2021;40:e106188. ) /Prev 809 0 R /Parent 343 0 R /Next 811 0 R >> endobj 811 0 obj << /Dest [18 0 R /XYZ 72 783 null] /Title (Prof Mala Maini ) /Prev 810 0 R /Parent 343 0 R /Next 812 0 R >> endobj 815 0 obj << /Dest [18 0 R /XYZ 72 768 null] /Title (m.maini@ucl.ac.uk) /Parent 814 0 R >> endobj 814 0 obj << /Count 1 /Dest [18 0 R /XYZ 0 842 null] /First 815 0 R /Last 815 0 R /Title (m.maini@ucl.ac.uk) /Parent 813 0 R /Next 816 0 R >> endobj 816 0 obj << /Dest [18 0 R /XYZ 72 768 null] /Title ( ) /Prev 814 0 R /Parent 813 0 R >> endobj 812 0 obj << /Dest [18 0 R /XYZ 419 784 null] /Title (Figure) /Prev 811 0 R /Parent 343 0 R /Next 813 0 R >> endobj 813 0 obj << /Count 3 /Dest [18 0 R /XYZ 0 842 null] /First 814 0 R /Last 816 0 R /Title (m.maini@ucl.ac.uk) /Prev 812 0 R /Parent 343 0 R /Next 817 0 R >> endobj 820 0 obj << /Dest [18 0 R /XYZ 72 739 null] /Title (/infection-immunity/people/professor-mala-maini) /Parent 819 0 R >> endobj 819 0 obj << /Count 1 /Dest [18 0 R /XYZ 0 842 null] /First 820 0 R /Last 820 0 R /Title (/infection-immunity/people/professor-mala-maini) /Parent 818 0 R /Next 821 0 R >> endobj 821 0 obj << /Dest [18 0 R /XYZ 72 724 null] /Title ( ) /Prev 819 0 R /Parent 818 0 R >> endobj 817 0 obj << /Dest [18 0 R /XYZ 72 754 null] /Title ( ) /Prev 813 0 R /Parent 343 0 R /Next 818 0 R >> endobj 818 0 obj << /Count 3 /Dest [18 0 R /XYZ 0 842 null] /First 819 0 R /Last 821 0 R /Title (/infection-immunity/people/professor-mala-maini) /Prev 817 0 R /Parent 343 0 R /Next 822 0 R >> endobj 822 0 obj << /Dest [18 0 R /XYZ 72 710 null] /Title ( ) /Prev 818 0 R /Parent 343 0 R /Next 823 0 R >> endobj 823 0 obj << /Dest [18 0 R /XYZ 72 695 null] /Title (We study immune responses in the liver, an organ that has evolved a uniquely tolerant immunological environment to deal with the onslaught of antigens it receives from the gut. Defining the characteristics of hepatic immunity is critical to understanding how three of the most prevalent and devastating human pathogens, HBV, HCV and malaria, take advantage of this niche in which to replicate and/or persist. Our group focuses on immune responses to hepatitis B in order to inform the development of novel immuno) /Prev 822 0 R /Parent 343 0 R /Next 824 0 R >> endobj 824 0 obj << /Dest [18 0 R /XYZ 72 569 null] /Title ( ) /Prev 823 0 R /Parent 343 0 R /Next 825 0 R >> endobj 825 0 obj << /Dest [18 0 R /XYZ 72 554 null] /Title (Liver disease is the only cause of mortality currently on the increase in the UK, due to the increase in alcoholic and fatty liver disease in addition to viral hepatitis. Liver inflammation and fibrosis leading to cirrhosis and liver cancer are unifying end-points in these diseases. To this end we are also now starting to dissect immune mechanisms in liver fibrosis and liver cancer. ) /Prev 824 0 R /Parent 343 0 R /Next 826 0 R >> endobj 826 0 obj << /Dest [18 0 R /XYZ 72 498 null] /Title ( ) /Prev 825 0 R /Parent 343 0 R /Next 827 0 R >> endobj 827 0 obj << /Dest [18 0 R /XYZ 409 374 null] /Title ( ) /Prev 826 0 R /Parent 343 0 R /Next 828 0 R >> endobj 828 0 obj << /Dest [18 0 R /XYZ 186 486 null] /Title (Figure) /Prev 827 0 R /Parent 343 0 R /Next 829 0 R >> endobj 829 0 obj << /Dest [18 0 R /XYZ 72 362 null] /Title ( ) /Prev 828 0 R /Parent 343 0 R /Next 830 0 R >> endobj 834 0 obj << /Dest [18 0 R /XYZ 325 334 null] /Title (http://www.ucl.ac.uk/maini-group) /Parent 833 0 R >> endobj 832 0 obj << /Dest [18 0 R /XYZ 72 334 null] /Title (Find out more about us and our work on our website: ) /Parent 831 0 R /Next 833 0 R >> endobj 833 0 obj << /Count 1 /Dest [18 0 R /XYZ 0 842 null] /First 834 0 R /Last 834 0 R /Title (http://www.ucl.ac.uk/maini-group) /Prev 832 0 R /Parent 831 0 R /Next 835 0 R >> endobj 835 0 obj << /Dest [18 0 R /XYZ 325 334 null] /Title ( ) /Prev 833 0 R /Parent 831 0 R >> endobj 830 0 obj << /Dest [18 0 R /XYZ 72 348 null] /Title (Our lab is an enthusiastic, sociable and committed group of basic and clinical scientists. ) /Prev 829 0 R /Parent 343 0 R /Next 831 0 R >> endobj 831 0 obj << /Count 4 /Dest [18 0 R /XYZ 72 334 null] /First 832 0 R /Last 835 0 R /Title (Find out more about us and our work on our website: ) /Prev 830 0 R /Parent 343 0 R /Next 836 0 R >> endobj 836 0 obj << /Dest [18 0 R /XYZ 72 320 null] /Title ( ) /Prev 831 0 R /Parent 343 0 R /Next 837 0 R >> endobj 837 0 obj << /Dest [18 0 R /XYZ 72 306 null] /Title (We are highly interactive, working closely with staff in a number of clinics to obtain the patient samples so vital to our work, as well as with scientific collaborators here at 911 and internationally \(see collaborators link in above website\). ) /Prev 836 0 R /Parent 343 0 R /Next 838 0 R >> endobj 838 0 obj << /Dest [18 0 R /XYZ 72 264 null] /Title ( ) /Prev 837 0 R /Parent 343 0 R /Next 839 0 R >> endobj 839 0 obj << /Dest [18 0 R /XYZ 72 250 null] /Title (We have a great track record, with our PhD and BSc students having very successful and enjoyable attachments to our group. Our students are renowned for publishing high impact papers that are highly cited and for having their work recognized with local and international prizes. ) /Prev 838 0 R /Parent 343 0 R /Next 840 0 R >> endobj 840 0 obj << /Dest [18 0 R /XYZ 72 207 null] /Title ( ) /Prev 839 0 R /Parent 343 0 R /Next 841 0 R >> endobj 841 0 obj << /Dest [18 0 R /XYZ 72 193 null] /Title (If you join our lab you will have your own project on a topical aspect of hepatitis immunity that will interlink with those of the other team members for maximum productivity. We have traditionally concentrated on antiviral T cell responses but are increasingly also studying NK cells, myeloid cells and specialized liver-resident cells \(e.g. stellate cells\). ) /Prev 840 0 R /Parent 343 0 R /Next 842 0 R >> endobj 842 0 obj << /Dest [18 0 R /XYZ 72 137 null] /Title ( ) /Prev 841 0 R /Parent 343 0 R /Next 843 0 R >> endobj 843 0 obj << /Dest [18 0 R /XYZ 72 122 null] /Title ( ) /Prev 842 0 R /Parent 343 0 R /Next 844 0 R >> endobj 844 0 obj << /Dest [18 0 R /XYZ 72 108 null] /Title ( ) /Prev 843 0 R /Parent 343 0 R /Next 845 0 R >> endobj 848 0 obj << /Dest [19 0 R /XYZ 72 769 null] /Title (c.mauri@ucl.ac.uk) /Parent 847 0 R >> endobj 847 0 obj << /Count 1 /Dest [19 0 R /XYZ 0 842 null] /First 848 0 R /Last 848 0 R /Title (c.mauri@ucl.ac.uk) /Parent 846 0 R /Next 849 0 R >> endobj 849 0 obj << /Dest [19 0 R /XYZ 72 769 null] /Title ( ) /Prev 847 0 R /Parent 846 0 R >> endobj 845 0 obj << /Dest [19 0 R /XYZ 72 783 null] /Title (Claudia Mauri ) /Prev 844 0 R /Parent 343 0 R /Next 846 0 R >> endobj 846 0 obj << /Count 3 /Dest [19 0 R /XYZ 0 842 null] /First 847 0 R /Last 849 0 R /Title (c.mauri@ucl.ac.uk) /Prev 845 0 R /Parent 343 0 R /Next 850 0 R >> endobj 850 0 obj << /Dest [19 0 R /XYZ 72 755 null] /Title ( ) /Prev 846 0 R /Parent 343 0 R /Next 851 0 R >> endobj 851 0 obj << /Dest [19 0 R /XYZ 72 742 null] /Title ( ) /Prev 850 0 R /Parent 343 0 R /Next 852 0 R >> endobj 852 0 obj << /Dest [19 0 R /XYZ 76 743 null] /Title (Figure) /Prev 851 0 R /Parent 343 0 R /Next 853 0 R >> endobj 853 0 obj << /Dest [19 0 R /XYZ 72 729 null] /Title ( ) /Prev 852 0 R /Parent 343 0 R /Next 854 0 R >> endobj 854 0 obj << /Dest [19 0 R /XYZ 72 717 null] /Title ( ) /Prev 853 0 R /Parent 343 0 R /Next 855 0 R >> endobj 855 0 obj << /Dest [19 0 R /XYZ 72 704 null] /Title ( ) /Prev 854 0 R /Parent 343 0 R /Next 856 0 R >> endobj 856 0 obj << /Dest [19 0 R /XYZ 72 691 null] /Title ( ) /Prev 855 0 R /Parent 343 0 R /Next 857 0 R >> endobj 857 0 obj << /Dest [19 0 R /XYZ 72 679 null] /Title ( ) /Prev 856 0 R /Parent 343 0 R /Next 858 0 R >> endobj 858 0 obj << /Dest [19 0 R /XYZ 72 666 null] /Title ( ) /Prev 857 0 R /Parent 343 0 R /Next 859 0 R >> endobj 859 0 obj << /Dest [19 0 R /XYZ 72 653 null] /Title ( ) /Prev 858 0 R /Parent 343 0 R /Next 860 0 R >> endobj 860 0 obj << /Dest [19 0 R /XYZ 72 641 null] /Title ( ) /Prev 859 0 R /Parent 343 0 R /Next 861 0 R >> endobj 861 0 obj << /Dest [19 0 R /XYZ 72 628 null] /Title ( ) /Prev 860 0 R /Parent 343 0 R /Next 862 0 R >> endobj 862 0 obj << /Dest [19 0 R /XYZ 72 615 null] /Title ( ) /Prev 861 0 R /Parent 343 0 R /Next 863 0 R >> endobj 863 0 obj << /Dest [19 0 R /XYZ 72 603 null] /Title ( ) /Prev 862 0 R /Parent 343 0 R /Next 864 0 R >> endobj 864 0 obj << /Dest [19 0 R /XYZ 72 590 null] /Title ( ) /Prev 863 0 R /Parent 343 0 R /Next 865 0 R >> endobj 865 0 obj << /Dest [19 0 R /XYZ 72 577 null] /Title ( ) /Prev 864 0 R /Parent 343 0 R /Next 866 0 R >> endobj 866 0 obj << /Dest [19 0 R /XYZ 72 565 null] /Title ( ) /Prev 865 0 R /Parent 343 0 R /Next 867 0 R >> endobj 867 0 obj << /Dest [19 0 R /XYZ 72 552 null] /Title ( ) /Prev 866 0 R /Parent 343 0 R /Next 868 0 R >> endobj 868 0 obj << /Dest [19 0 R /XYZ 72 540 null] /Title ( ) /Prev 867 0 R /Parent 343 0 R /Next 869 0 R >> endobj 872 0 obj << /Dest [19 0 R /XYZ 72 514 null] /Title (https://iris.ucl.ac.uk/iris/browse/profile?upi=CMAUR43) /Parent 871 0 R >> endobj 871 0 obj << /Count 1 /Dest [19 0 R /XYZ 0 842 null] /First 872 0 R /Last 872 0 R /Title (https://iris.ucl.ac.uk/iris/browse/profile?upi=CMAUR43) /Parent 870 0 R /Next 873 0 R >> endobj 873 0 obj << /Dest [19 0 R /XYZ 72 514 null] /Title ( ) /Prev 871 0 R /Parent 870 0 R >> endobj 869 0 obj << /Dest [19 0 R /XYZ 72 527 null] /Title ( ) /Prev 868 0 R /Parent 343 0 R /Next 870 0 R >> endobj 870 0 obj << /Count 3 /Dest [19 0 R /XYZ 0 842 null] /First 871 0 R /Last 873 0 R /Title (https://iris.ucl.ac.uk/iris/browse/profile?upi=CMAUR43) /Prev 869 0 R /Parent 343 0 R /Next 874 0 R >> endobj 874 0 obj << /Dest [19 0 R /XYZ 72 501 null] /Title ( ) /Prev 870 0 R /Parent 343 0 R /Next 875 0 R >> endobj 875 0 obj << /Dest [19 0 R /XYZ 72 489 null] /Title (We are a very dynamic and culturally diverse group, whom research focuses on delineating the cellular and molecular mechanisms controlling immune-regulation in health and how these pathways are dysregulated in autoimmune disease. We have pioneered the discovery of a novel subset of B-cells, known as regulatory B-cells \(Bregs\), which possess powerful immune-suppressive capacity. Our studies have overturned the pre-existing paradigm of B-cells being exclusively pathogenic in autoimmunity. In mice and humans, ) /Prev 874 0 R /Parent 343 0 R /Next 876 0 R >> endobj 876 0 obj << /Dest [19 0 R /XYZ 72 223 null] /Title ( ) /Prev 875 0 R /Parent 343 0 R /Next 877 0 R >> endobj 877 0 obj << /Dest [19 0 R /XYZ 72 208 null] /Title (The projects available will aim to investigate 1\) the effect that diet and/or dietary components have on the metabolism of B cells 2\) how changes in the gut-microbiota can be harness for the cure of rheumatoid arthritis. ) /Prev 876 0 R /Parent 343 0 R /Next 878 0 R >> endobj 878 0 obj << /Dest [19 0 R /XYZ 72 166 null] /Title ( ) /Prev 877 0 R /Parent 343 0 R /Next 879 0 R >> endobj 879 0 obj << /Dest [19 0 R /XYZ 72 152 null] /Title ( ) /Prev 878 0 R /Parent 343 0 R /Next 880 0 R >> endobj 880 0 obj << /Dest [19 0 R /XYZ 72 137 null] /Title ( ) /Prev 879 0 R /Parent 343 0 R /Next 881 0 R >> endobj 881 0 obj << /Dest [20 0 R /XYZ 72 783 null] /Title (Dr Andreas Mayer ) /Prev 880 0 R /Parent 343 0 R /Next 882 0 R >> endobj 885 0 obj << /Dest [20 0 R /XYZ 72 768 null] /Title (andimscience@gmail.com) /Parent 884 0 R >> endobj 884 0 obj << /Count 1 /Dest [20 0 R /XYZ 0 842 null] /First 885 0 R /Last 885 0 R /Title (andimscience@gmail.com) /Parent 883 0 R /Next 886 0 R >> endobj 886 0 obj << /Dest [20 0 R /XYZ 72 768 null] /Title ( ) /Prev 884 0 R /Parent 883 0 R >> endobj 882 0 obj << /Dest [20 0 R /XYZ 332 785 null] /Title (Figure) /Prev 881 0 R /Parent 343 0 R /Next 883 0 R >> endobj 883 0 obj << /Count 3 /Dest [20 0 R /XYZ 0 842 null] /First 884 0 R /Last 886 0 R /Title (andimscience@gmail.com) /Prev 882 0 R /Parent 343 0 R /Next 887 0 R >> endobj 887 0 obj << /Dest [20 0 R /XYZ 72 754 null] /Title ( ) /Prev 883 0 R /Parent 343 0 R /Next 888 0 R >> endobj 888 0 obj << /Dest [20 0 R /XYZ 72 739 null] /Title ( ) /Prev 887 0 R /Parent 343 0 R /Next 889 0 R >> endobj 889 0 obj << /Dest [20 0 R /XYZ 72 724 null] /Title ( ) /Prev 888 0 R /Parent 343 0 R /Next 890 0 R >> endobj 890 0 obj << /Dest [20 0 R /XYZ 72 710 null] /Title ( ) /Prev 889 0 R /Parent 343 0 R /Next 891 0 R >> endobj 891 0 obj << /Dest [20 0 R /XYZ 72 695 null] /Title ( ) /Prev 890 0 R /Parent 343 0 R /Next 892 0 R >> endobj 892 0 obj << /Dest [20 0 R /XYZ 72 666 null] /Title (T cell repertoire as a complex ecosystem ) /Prev 891 0 R /Parent 343 0 R /Next 893 0 R >> endobj 893 0 obj << /Dest [20 0 R /XYZ 72 614 null] /Title (The evolution of diverse clonal populations underlies the development of cancers, antibiotic resistance, and protective immune responses. Predicting outcomes of the dynamical processes shaping clonal evolution is of considerable practical importance, but the current theory breaks down when analysing highly diverse populations where there are many distinct clones. An important example of such a system is the adaptive immune system, where the highly diverse antigen receptors act as natural genetic 'barcodes' ) /Prev 892 0 R /Parent 343 0 R /Next 894 0 R >> endobj 894 0 obj << /Dest [20 0 R /XYZ 72 321 null] /Title ( ) /Prev 893 0 R /Parent 343 0 R /Next 895 0 R >> endobj 895 0 obj << /Dest [20 0 R /XYZ 72 302 null] /Title ( ) /Prev 894 0 R /Parent 343 0 R /Next 896 0 R >> endobj 896 0 obj << /Dest [21 0 R /XYZ 72 783 null] /Title (Dr Mahdad Noursadeghi ) /Prev 895 0 R /Parent 343 0 R /Next 897 0 R >> endobj 900 0 obj << /Dest [21 0 R /XYZ 72 768 null] /Title (m.noursadeghi@ucl.ac.uk) /Parent 899 0 R >> endobj 899 0 obj << /Count 1 /Dest [21 0 R /XYZ 0 842 null] /First 900 0 R /Last 900 0 R /Title (m.noursadeghi@ucl.ac.uk) /Parent 898 0 R /Next 901 0 R >> endobj 901 0 obj << /Dest [21 0 R /XYZ 72 768 null] /Title ( ) /Prev 899 0 R /Parent 898 0 R >> endobj 897 0 obj << /Dest [21 0 R /XYZ 413 785 null] /Title (Figure) /Prev 896 0 R /Parent 343 0 R /Next 898 0 R >> endobj 898 0 obj << /Count 3 /Dest [21 0 R /XYZ 0 842 null] /First 899 0 R /Last 901 0 R /Title (m.noursadeghi@ucl.ac.uk) /Prev 897 0 R /Parent 343 0 R /Next 902 0 R >> endobj 905 0 obj << /Dest [21 0 R /XYZ 72 739 null] /Title (/infection-immunity/people/professor-mahdad-noursadeghi) /Parent 904 0 R >> endobj 904 0 obj << /Count 1 /Dest [21 0 R /XYZ 0 842 null] /First 905 0 R /Last 905 0 R /Title (/infection-immunity/people/professor-mahdad-noursadeghi) /Parent 903 0 R /Next 906 0 R >> endobj 906 0 obj << /Dest [21 0 R /XYZ 72 724 null] /Title ( ) /Prev 904 0 R /Parent 903 0 R >> endobj 902 0 obj << /Dest [21 0 R /XYZ 72 754 null] /Title ( ) /Prev 898 0 R /Parent 343 0 R /Next 903 0 R >> endobj 903 0 obj << /Count 3 /Dest [21 0 R /XYZ 0 842 null] /First 904 0 R /Last 906 0 R /Title (/infection-immunity/people/professor-mahdad-noursadeghi) /Prev 902 0 R /Parent 343 0 R /Next 907 0 R >> endobj 907 0 obj << /Dest [21 0 R /XYZ 44 710 null] /Title ( ) /Prev 903 0 R /Parent 343 0 R /Next 908 0 R >> endobj 908 0 obj << /Dest [21 0 R /XYZ 72 695 null] /Title (We investigate host-pathogen interactions in order to increase our mechanistic understanding of protective and pathogenic immune responses in infectious diseases, and inform the development of novel therapies or approaches for patient stratification. We particularly focus on innate immunity by modelling host-pathogen interactions in human macrophages. Although macrophages are important sentinels of the immune system, which can sense and respond to danger, restrict pathogens by intracellular killing pathways) /Prev 907 0 R /Parent 343 0 R /Next 909 0 R >> endobj 909 0 obj << /Dest [21 0 R /XYZ 72 442 null] /Title ( ) /Prev 908 0 R /Parent 343 0 R /Next 910 0 R >> endobj 910 0 obj << /Dest [21 0 R /XYZ 72 428 null] /Title (Existing projects in the group include: ) /Prev 909 0 R /Parent 343 0 R /Next 911 0 R >> endobj 914 0 obj << /Dest [21 0 R /XYZ 90 400 null] /Title (\200 HIV-1 & Mycobacterium tuberculosis co-infection in macrophages ) /Parent 913 0 R >> endobj 916 0 obj << /Dest [21 0 R /XYZ 90 385 null] /Title (\200 Defining protective immunity to human tuberculosis ) /Parent 915 0 R >> endobj 913 0 obj << /Count 1 /Dest [21 0 R /XYZ 90 400 null] /First 914 0 R /Last 914 0 R /Title (\200 HIV-1 & Mycobacterium tuberculosis co-infection in macrophages ) /Parent 912 0 R /Next 915 0 R >> endobj 918 0 obj << /Dest [21 0 R /XYZ 90 370 null] /Title (\200 Augmentation and regulation of immune responses to tuberculosis by vitamin D ) /Parent 917 0 R >> endobj 915 0 obj << /Count 1 /Dest [21 0 R /XYZ 90 385 null] /First 916 0 R /Last 916 0 R /Title (\200 Defining protective immunity to human tuberculosis ) /Prev 913 0 R /Parent 912 0 R /Next 917 0 R >> endobj 920 0 obj << /Dest [21 0 R /XYZ 90 356 null] /Title (\200 Innate immune governance of the fate of inflammatory monocytes in tuberculosis ) /Parent 919 0 R >> endobj 917 0 obj << /Count 1 /Dest [21 0 R /XYZ 90 370 null] /First 918 0 R /Last 918 0 R /Title (\200 Augmentation and regulation of immune responses to tuberculosis by vitamin D ) /Prev 915 0 R /Parent 912 0 R /Next 919 0 R >> endobj 922 0 obj << /Dest [21 0 R /XYZ 90 341 null] /Title (\200 Targeting neutrophil recruitment in pneumococcal meningitis ) /Parent 921 0 R >> endobj 919 0 obj << /Count 1 /Dest [21 0 R /XYZ 90 356 null] /First 920 0 R /Last 920 0 R /Title (\200 Innate immune governance of the fate of inflammatory monocytes in tuberculosis ) /Prev 917 0 R /Parent 912 0 R /Next 921 0 R >> endobj 921 0 obj << /Count 1 /Dest [21 0 R /XYZ 90 341 null] /First 922 0 R /Last 922 0 R /Title (\200 Targeting neutrophil recruitment in pneumococcal meningitis ) /Prev 919 0 R /Parent 912 0 R >> endobj 911 0 obj << /Dest [21 0 R /XYZ 72 414 null] /Title ( ) /Prev 910 0 R /Parent 343 0 R /Next 912 0 R >> endobj 912 0 obj << /Count 10 /Dest [21 0 R /XYZ 90 400 null] /First 913 0 R /Last 921 0 R /Title (\200 HIV-1 & Mycobacterium tuberculosis co-infection in macrophages ) /Prev 911 0 R /Parent 343 0 R /Next 923 0 R >> endobj 923 0 obj << /Dest [21 0 R /XYZ 72 327 null] /Title ( ) /Prev 912 0 R /Parent 343 0 R /Next 924 0 R >> endobj 924 0 obj << /Dest [21 0 R /XYZ 72 313 null] /Title (Selected references: ) /Prev 923 0 R /Parent 343 0 R /Next 925 0 R >> endobj 929 0 obj << /Dest [21 0 R /XYZ 156 257 null] /Title (doi: 10.1016/j.chom.2014.06.009) /Parent 928 0 R >> endobj 927 0 obj << /Dest [21 0 R /XYZ 72 268 null] /Title (Towers G and Noursadeghi M. Interactions between HIV-1 and the Cell-Autonomous Innate Immune System. 2014. Cell Host & Microbe 2014 \() /Parent 926 0 R /Next 928 0 R >> endobj 928 0 obj << /Count 1 /Dest [21 0 R /XYZ 0 842 null] /First 929 0 R /Last 929 0 R /Title (doi: 10.1016/j.chom.2014.06.009) /Prev 927 0 R /Parent 926 0 R /Next 930 0 R >> endobj 930 0 obj << /Dest [21 0 R /XYZ 156 257 null] /Title (\). ) /Prev 928 0 R /Parent 926 0 R >> endobj 925 0 obj << /Dest [21 0 R /XYZ 72 301 null] /Title (Tomlinson G, Chimalapati S, Pollard T, Lapp T, Cohen J, Camberlein E, Stafford S, Periselneris J, Aldridge C, Vollmer W, Picard C, Casanova J-L, Noursadeghi M, Brown J*. TLR-mediated inflammatory responses to Streptococcus pneumoniae are highly dependent on surface expression of bacterial lipoproteins. J Immunology 2014 \(doi:10.4049/jimmunol.1401413\). ) /Prev 924 0 R /Parent 343 0 R /Next 926 0 R >> endobj 926 0 obj << /Count 4 /Dest [21 0 R /XYZ 72 268 null] /First 927 0 R /Last 930 0 R /Title (Towers G and Noursadeghi M. Interactions between HIV-1 and the Cell-Autonomous Innate Immune System. 2014. Cell Host & Microbe 2014 \() /Prev 925 0 R /Parent 343 0 R /Next 931 0 R >> endobj 931 0 obj << /Dest [21 0 R /XYZ 72 246 null] /Title (Mlcochova P, Watters S, Towers GJ, Noursadeghi M, Gupta RK. Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages. Retrovirology. 2014 \(doi: 10.1186/1742-4690-11-25\). ) /Prev 926 0 R /Parent 343 0 R /Next 932 0 R >> endobj 932 0 obj << /Dest [21 0 R /XYZ 72 224 null] /Title (Kundu R, Chain BM, Coussens AK, Khoo B, Noursadeghi M. Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells. Eur J Immunol. 2014 \(doi: 10.1002/eji.201344157\). ) /Prev 931 0 R /Parent 343 0 R /Next 933 0 R >> endobj 933 0 obj << /Dest [21 0 R /XYZ 72 202 null] /Title (Tomlinson GS, Bell LCK, Walker NF, Tsang J, Brown JS, Breen R, Lipman M, Katz DR, Miller RF, Chain BM, Elkington PTG, Noursadeghi M. HIV-1 infection of macrophages dysregulates innate immune responses to Mycobacterium tuberculosis by inhibition of interleukin 10. J Infectious Diseases. 2013 \(doi: 10.1093/infdis/jit621\). ) /Prev 932 0 R /Parent 343 0 R /Next 934 0 R >> endobj 934 0 obj << /Dest [21 0 R /XYZ 72 169 null] /Title (Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ*. HIV-1 evades innate immune recognition through specific co-factor recruitment. Nature. 2013. \(doi:10.1038/nature12675\). ) /Prev 933 0 R /Parent 343 0 R /Next 935 0 R >> endobj 935 0 obj << /Dest [21 0 R /XYZ 72 136 null] /Title (Tomlinson GS, Cashmore TJ, Elkington PTG, Yates J, Lehloenya RJ, Tsang J, Brown M, Miller RF, Dheda K, Katz DR, Chain BM, Noursadeghi M. Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test. Eur J Immunol. 2011, \(doi:10.1002/eji.201141841\). ) /Prev 934 0 R /Parent 343 0 R /Next 936 0 R >> endobj 936 0 obj << /Dest [21 0 R /XYZ 72 102 null] /Title ( ) /Prev 935 0 R /Parent 343 0 R /Next 937 0 R >> endobj 937 0 obj << /Dest [21 0 R /XYZ 72 88 null] /Title ( ) /Prev 936 0 R /Parent 343 0 R /Next 938 0 R >> endobj 938 0 obj << /Dest [22 0 R /XYZ 72 783 null] /Title (Dr Laura Pallett ) /Prev 937 0 R /Parent 343 0 R /Next 939 0 R >> endobj 939 0 obj << /Dest [22 0 R /XYZ 412 784 null] /Title (Figure) /Prev 938 0 R /Parent 343 0 R /Next 940 0 R >> endobj 944 0 obj << /Dest [22 0 R /XYZ 102 755 null] /Title (laura.pallett@ucl.ac.uk) /Parent 943 0 R >> endobj 942 0 obj << /Dest [22 0 R /XYZ 72 755 null] /Title (Email: ) /Parent 941 0 R /Next 943 0 R >> endobj 943 0 obj << /Count 1 /Dest [22 0 R /XYZ 0 842 null] /First 944 0 R /Last 944 0 R /Title (laura.pallett@ucl.ac.uk) /Prev 942 0 R /Parent 941 0 R /Next 945 0 R >> endobj 945 0 obj << /Dest [22 0 R /XYZ 72 755 null] /Title ( ) /Prev 943 0 R /Parent 941 0 R >> endobj 940 0 obj << /Dest [22 0 R /XYZ 403 769 null] /Title ( ) /Prev 939 0 R /Parent 343 0 R /Next 941 0 R >> endobj 941 0 obj << /Count 4 /Dest [22 0 R /XYZ 72 755 null] /First 942 0 R /Last 945 0 R /Title (Email: ) /Prev 940 0 R /Parent 343 0 R /Next 946 0 R >> endobj 949 0 obj << /Dest [22 0 R /XYZ 72 728 null] /Title (www.pallettlab.com) /Parent 948 0 R >> endobj 948 0 obj << /Count 1 /Dest [22 0 R /XYZ 0 842 null] /First 949 0 R /Last 949 0 R /Title (www.pallettlab.com) /Parent 947 0 R /Next 950 0 R >> endobj 950 0 obj << /Dest [22 0 R /XYZ 72 728 null] /Title ( ) /Prev 948 0 R /Parent 947 0 R >> endobj 946 0 obj << /Dest [22 0 R /XYZ 72 742 null] /Title (Twitter: @pallett_lab ) /Prev 941 0 R /Parent 343 0 R /Next 947 0 R >> endobj 947 0 obj << /Count 3 /Dest [22 0 R /XYZ 0 842 null] /First 948 0 R /Last 950 0 R /Title (www.pallettlab.com) /Prev 946 0 R /Parent 343 0 R /Next 951 0 R >> endobj 951 0 obj << /Dest [22 0 R /XYZ 72 715 null] /Title ( ) /Prev 947 0 R /Parent 343 0 R /Next 952 0 R >> endobj 952 0 obj << /Dest [22 0 R /XYZ 72 701 null] /Title ( ) /Prev 951 0 R /Parent 343 0 R /Next 953 0 R >> endobj 953 0 obj << /Dest [22 0 R /XYZ 72 688 null] /Title ( ) /Prev 952 0 R /Parent 343 0 R /Next 954 0 R >> endobj 954 0 obj << /Dest [22 0 R /XYZ 72 675 null] /Title (Tissue-resident T cells in the human liver in health and disease \205 adapting to survive and function. ) /Prev 953 0 R /Parent 343 0 R /Next 955 0 R >> endobj 955 0 obj << /Dest [22 0 R /XYZ 72 648 null] /Title ( ) /Prev 954 0 R /Parent 343 0 R /Next 956 0 R >> endobj 956 0 obj << /Dest [22 0 R /XYZ 72 634 null] /Title (In the Pallett lab we study how T cells adapt once they enter the liver environment. We are particularly interested in the cellular \217conversation\220 between T cells and the underlying stroma and how this conversation impacts T cell function. We have previously highlighted the importance of a highly specialised population of memory T cells, named tissue-resident T cells \(or TRM\) that reside permanently within the liver, unable to recirculate round the body. These \217frontline immune sentinels\220 mediate rapid resp) /Prev 955 0 R /Parent 343 0 R /Next 957 0 R >> endobj 957 0 obj << /Dest [22 0 R /XYZ 72 500 null] /Title ( ) /Prev 956 0 R /Parent 343 0 R /Next 958 0 R >> endobj 958 0 obj << /Dest [22 0 R /XYZ 72 487 null] /Title (Why do we care? In 2018 cirrhosis \(and associated liver disease\) was named the leading cause of mortality in individuals aged 35-49 in the UK. Worldwide cirrhosis, and its complications cause >1.32 million deaths each year, with many considered preventable due to the growing contribution of obesity and alcohol misuse to this burden. But as it stands there are no direct anti-fibrotic treatments available, so there is an urgent unmet clinical need to understand immunological mechanisms of fibrosis/cirrhosis t) /Prev 957 0 R /Parent 343 0 R /Next 959 0 R >> endobj 959 0 obj << /Dest [22 0 R /XYZ 72 406 null] /Title ( ) /Prev 958 0 R /Parent 343 0 R /Next 960 0 R >> endobj 960 0 obj << /Dest [22 0 R /XYZ 72 392 null] /Title (If you would like to come join us in the Pallett lab you will embark on a dynamic project to unravel bits of the cellular \217conversation\220 involved in fibrogenic processes within the liver. The project will involve working closely with our clinical colleagues to obtain high-quality tissue samples, and exciting state-of-the-art technologies, such as multiplex imaging \(TRM location in collaboration with the Francis Crick Institute\), CyTOF \(to determine the cellular conversation in collaboration with the Tape la) /Prev 959 0 R /Parent 343 0 R /Next 961 0 R >> endobj 961 0 obj << /Dest [22 0 R /XYZ 72 285 null] /Title ( ) /Prev 960 0 R /Parent 343 0 R /Next 962 0 R >> endobj 962 0 obj << /Dest [22 0 R /XYZ 72 266 null] /Title (Selected relevant publications: ) /Prev 961 0 R /Parent 343 0 R /Next 963 0 R >> endobj 963 0 obj << /Dest [22 0 R /XYZ 70 241 null] /Title (1. Pallett L.J. et al JEM \(2017\) \215IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection\216 ) /Prev 962 0 R /Parent 343 0 R /Next 964 0 R >> endobj 964 0 obj << /Dest [22 0 R /XYZ 371 278 null] /Title (Figure) /Prev 963 0 R /Parent 343 0 R /Next 965 0 R >> endobj 965 0 obj << /Dest [22 0 R /XYZ 70 218 null] /Title (2. Gill U.S. & Pallett L.J. et al Gut \(2019\) \215Fine needle aspirates comprehensively sample intrahepatic immunity\216 ) /Prev 964 0 R /Parent 343 0 R /Next 966 0 R >> endobj 966 0 obj << /Dest [22 0 R /XYZ 70 195 null] /Title (3. Pallett L.J. & Burton A.R. et al JEM \(2020\) \215Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocyte\216 ) /Prev 965 0 R /Parent 343 0 R /Next 967 0 R >> endobj 967 0 obj << /Dest [22 0 R /XYZ 70 172 null] /Title (4. Ichikawa T. et al Nat Immunol \(2019\) \215CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells\216 ) /Prev 966 0 R /Parent 343 0 R /Next 968 0 R >> endobj 968 0 obj << /Dest [22 0 R /XYZ 72 133 null] /Title ( ) /Prev 967 0 R /Parent 343 0 R /Next 969 0 R >> endobj 969 0 obj << /Dest [22 0 R /XYZ 72 118 null] /Title ( ) /Prev 968 0 R /Parent 343 0 R /Next 970 0 R >> endobj 970 0 obj << /Dest [23 0 R /XYZ 72 784 null] /Title (Dr Dimitra Peppa ) /Prev 969 0 R /Parent 343 0 R /Next 971 0 R >> endobj 971 0 obj << /Dest [23 0 R /XYZ 417 785 null] /Title (Figure) /Prev 970 0 R /Parent 343 0 R /Next 972 0 R >> endobj 975 0 obj << /Dest [23 0 R /XYZ 72 756 null] /Title (d.peppa@ucl.ac.uk) /Parent 974 0 R >> endobj 974 0 obj << /Count 1 /Dest [23 0 R /XYZ 0 842 null] /First 975 0 R /Last 975 0 R /Title (d.peppa@ucl.ac.uk) /Parent 973 0 R /Next 976 0 R >> endobj 976 0 obj << /Dest [23 0 R /XYZ 72 756 null] /Title ( ) /Prev 974 0 R /Parent 973 0 R >> endobj 972 0 obj << /Dest [23 0 R /XYZ 72 770 null] /Title ( ) /Prev 971 0 R /Parent 343 0 R /Next 973 0 R >> endobj 979 0 obj << /Dest [23 0 R /XYZ 72 743 null] /Title (/infection-immunity/people/dr-dimitra-peppa) /Parent 978 0 R >> endobj 978 0 obj << /Count 1 /Dest [23 0 R /XYZ 0 842 null] /First 979 0 R /Last 979 0 R /Title (/infection-immunity/people/dr-dimitra-peppa) /Parent 977 0 R /Next 980 0 R >> endobj 980 0 obj << /Dest [23 0 R /XYZ 72 743 null] /Title ( ) /Prev 978 0 R /Parent 977 0 R >> endobj 973 0 obj << /Count 3 /Dest [23 0 R /XYZ 0 842 null] /First 974 0 R /Last 976 0 R /Title (d.peppa@ucl.ac.uk) /Prev 972 0 R /Parent 343 0 R /Next 977 0 R >> endobj 977 0 obj << /Count 3 /Dest [23 0 R /XYZ 0 842 null] /First 978 0 R /Last 980 0 R /Title (/infection-immunity/people/dr-dimitra-peppa) /Prev 973 0 R /Parent 343 0 R /Next 981 0 R >> endobj 981 0 obj << /Dest [23 0 R /XYZ 72 729 null] /Title ( ) /Prev 977 0 R /Parent 343 0 R /Next 982 0 R >> endobj 982 0 obj << /Dest [23 0 R /XYZ 72 716 null] /Title (The Peppa lab has an interest in chronic viral diseases \(HBV, HIV\) and emerging viral infections \(SARS-CoV-2\) of global health significance with a strong focus on translational research. Our research work benefits from unprecedented access to one of the largest and well characterised clinical cohorts of people living with HIV and viral hepatitis patients; these groups of patients suffer detrimental health care outcomes associated with immune dysfunction, ongoing inflammation, accelerated ageing and increase) /Prev 981 0 R /Parent 343 0 R /Next 983 0 R >> endobj 983 0 obj << /Dest [23 0 R /XYZ 72 595 null] /Title ( ) /Prev 982 0 R /Parent 343 0 R /Next 984 0 R >> endobj 987 0 obj << /Dest [23 0 R /XYZ 72 567 null] /Title (\200 Identification of novel therapeutic targets and/or predictive biomarkers: This project involves integration of \217omic technologies\220 to infer regulatory networks and drivers of immunity and ongoing inflammation in distinct anatomical compartments in patients with HIV and CMV coinfection. This high-resolution strategy will enable patient monitoring and stratification for therapeutic interventions to prevent comorbidities associated with premature ageing. ) /Parent 986 0 R >> endobj 989 0 obj << /Dest [23 0 R /XYZ 72 500 null] /Title (\200 Development of NK based cellular therapeutics: Develop a scalable platform for the expansion of adaptive NK cells with enhanced functionality and predictable selectivity. Genetic engineer human NK cells with features that improve their capacity to recognise and kill HIV- and HBV-infected target cells \(in collaboration with Waggoner Lab, USA\). This approach could circumvent many of the limitations inherent to the current immunotherapeutic approaches as a novel therapeutic avenue for viral disease. ) /Parent 988 0 R >> endobj 986 0 obj << /Count 1 /Dest [23 0 R /XYZ 72 567 null] /First 987 0 R /Last 987 0 R /Title (\200 Identification of novel therapeutic targets and/or predictive biomarkers: This project involves integration of \217omic technologies\220 to infer regulatory networks and drivers of immunity and ongoing inflammation in distinct anatomical compartments in patients with HIV and CMV coinfection. This high-resolution strategy will enable patient monitoring and stratification for therapeutic interventions to prevent comorbidities associated with premature ageing. ) /Parent 985 0 R /Next 988 0 R >> endobj 991 0 obj << /Dest [23 0 R /XYZ 72 419 null] /Title (\200 HIV related immunosuppression and responses to SARS-CoV-2: There is currently little information on vaccine efficacy/correlates of protection in this vulnerable population group. This work will examine the development of specialised NK cell populations exhibiting memory-like features in response to natural infection and vaccination with implications for the development of new vaccine targets. ) /Parent 990 0 R >> endobj 988 0 obj << /Count 1 /Dest [23 0 R /XYZ 72 500 null] /First 989 0 R /Last 989 0 R /Title (\200 Development of NK based cellular therapeutics: Develop a scalable platform for the expansion of adaptive NK cells with enhanced functionality and predictable selectivity. Genetic engineer human NK cells with features that improve their capacity to recognise and kill HIV- and HBV-infected target cells \(in collaboration with Waggoner Lab, USA\). This approach could circumvent many of the limitations inherent to the current immunotherapeutic approaches as a novel therapeutic avenue for viral disease. ) /Prev 986 0 R /Parent 985 0 R /Next 990 0 R >> endobj 990 0 obj << /Count 1 /Dest [23 0 R /XYZ 72 419 null] /First 991 0 R /Last 991 0 R /Title (\200 HIV related immunosuppression and responses to SARS-CoV-2: There is currently little information on vaccine efficacy/correlates of protection in this vulnerable population group. This work will examine the development of specialised NK cell populations exhibiting memory-like features in response to natural infection and vaccination with implications for the development of new vaccine targets. ) /Prev 988 0 R /Parent 985 0 R >> endobj 984 0 obj << /Dest [23 0 R /XYZ 72 582 null] /Title (Available projects include: ) /Prev 983 0 R /Parent 343 0 R /Next 985 0 R >> endobj 985 0 obj << /Count 6 /Dest [23 0 R /XYZ 72 567 null] /First 986 0 R /Last 990 0 R /Title (\200 Identification of novel therapeutic targets and/or predictive biomarkers: This project involves integration of \217omic technologies\220 to infer regulatory networks and drivers of immunity and ongoing inflammation in distinct anatomical compartments in patients with HIV and CMV coinfection. This high-resolution strategy will enable patient monitoring and stratification for therapeutic interventions to prevent comorbidities associated with premature ageing. ) /Prev 984 0 R /Parent 343 0 R /Next 992 0 R >> endobj 992 0 obj << /Dest [23 0 R /XYZ 72 344 null] /Title (Training opportunities ) /Prev 985 0 R /Parent 343 0 R /Next 993 0 R >> endobj 993 0 obj << /Dest [23 0 R /XYZ 72 330 null] /Title (The Institute of Immunity and Transplantation, Pears Building, provides world-class laboratory facilities for virology, immunology, and clinical research. Outstanding research amenities at include equipment and services for cellular immunology \(state of the art flow cytometry facilities\), immunometabolism \(Seahorse technology\), molecular and experimental medicine, human genomics, vaccine development, cellular imaging, genetic engineering, and bioinformatics. ) /Prev 992 0 R /Parent 343 0 R /Next 994 0 R >> endobj 994 0 obj << /Dest [23 0 R /XYZ 72 264 null] /Title ( ) /Prev 993 0 R /Parent 343 0 R /Next 995 0 R >> endobj 998 0 obj << /Dest [23 0 R /XYZ 72 241 null] /Title (1. Touizer E, Alrubayyi A, Rees-Spear C, Fisher-Pearson N, Griffith S, Muir L, Pellegrino P, Waters L, Burns F, Kinloch S, Rowland-Jones S, Gupta K R, Gilosn R, Peppa D, McCoy L. Failure to seroconvert after two doses of BNT162b2 SARS-CoV-2 vaccine in uncontrolled HIV infection. Lancet HIV May 2021. ) /Parent 997 0 R >> endobj 1000 0 obj << /Dest [23 0 R /XYZ 72 212 null] /Title (2. Aljawharah Alrubayyi, Ester Gea-Mallorqu\355, Emma Touizer, Dan Hameiri-Bowen, Jakub Kopycinski, Bethany Charlton, Natasha Fisher-Pearson, Luke Muir, Annachiara Rosa, Chloe Roustan, Christopher Earl, Peter Cherepanov, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Tao Dong, Lucy Dorrell, Sarah Rowland-Jones, Laura E. McCoy, Dimitra Peppa. Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV. Nat Commun 12, 5839 \(2021\). https://doi.org/10.1038/s41467-0) /Parent 999 0 R >> endobj 997 0 obj << /Count 1 /Dest [23 0 R /XYZ 72 241 null] /First 998 0 R /Last 998 0 R /Title (1. Touizer E, Alrubayyi A, Rees-Spear C, Fisher-Pearson N, Griffith S, Muir L, Pellegrino P, Waters L, Burns F, Kinloch S, Rowland-Jones S, Gupta K R, Gilosn R, Peppa D, McCoy L. Failure to seroconvert after two doses of BNT162b2 SARS-CoV-2 vaccine in uncontrolled HIV infection. Lancet HIV May 2021. ) /Parent 996 0 R /Next 999 0 R >> endobj 1002 0 obj << /Dest [23 0 R /XYZ 469 175 null] /Title /Parent 1001 0 R >> endobj 999 0 obj << /Count 1 /Dest [23 0 R /XYZ 72 212 null] /First 1000 0 R /Last 1000 0 R /Title (2. Aljawharah Alrubayyi, Ester Gea-Mallorqu\355, Emma Touizer, Dan Hameiri-Bowen, Jakub Kopycinski, Bethany Charlton, Natasha Fisher-Pearson, Luke Muir, Annachiara Rosa, Chloe Roustan, Christopher Earl, Peter Cherepanov, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Tao Dong, Lucy Dorrell, Sarah Rowland-Jones, Laura E. McCoy, Dimitra Peppa. Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV. Nat Commun 12, 5839 \(2021\). https://doi.org/10.1038/s41467-0) /Prev 997 0 R /Parent 996 0 R /Next 1001 0 R >> endobj 1004 0 obj << /Dest [23 0 R /XYZ 169 155 null] /Title (4. Maini MK and Peppa D. Shared immunotherapeutic approaches in HIV and HBV: Combine and Conquer. Current Opinion in HIV and AIDS. 2020 ) /Parent 1003 0 R >> endobj 1001 0 obj << /Count 1 /Dest [23 0 R /XYZ 469 175 null] /First 1002 0 R /Last 1002 0 R /Title /Prev 999 0 R /Parent 996 0 R /Next 1003 0 R >> endobj 1006 0 obj << /Dest [23 0 R /XYZ 72 134 null] /Title (5. Bradley T, Peppa D, Pedroza-Pacheco I, Li D, Cain DW, Henao R, Venkat V, Hora B, Chen Y, Vandergrift NA, Overman RG, Edwards RW, Woods CW, Tomaras GD, Ferrari G, Ginsburg GS, Connors M, Cohen MS, Moody MA, Borrow P, Haynes BF. RAB11FIP5 expression and altered natural killer cell function are associated with induction of HIV broadly neutralizing antibody responses, Cell 2018 Oct 4;175\(2\):387-399e17. ) /Parent 1005 0 R >> endobj 1003 0 obj << /Count 1 /Dest [23 0 R /XYZ 169 155 null] /First 1004 0 R /Last 1004 0 R /Title (4. Maini MK and Peppa D. Shared immunotherapeutic approaches in HIV and HBV: Combine and Conquer. Current Opinion in HIV and AIDS. 2020 ) /Prev 1001 0 R /Parent 996 0 R /Next 1005 0 R >> endobj 1008 0 obj << /Dest [23 0 R /XYZ 72 104 null] /Title (6. Peppa D, Pedroza-Pacheco I, Pellegrino P, Williams I, Maini MK, Borrow P. Adaptive Reconfiguration of Natural Killer Cells in HIV-1 Infection. Front Immunol. 2018 Mar 16;9:474. ) /Parent 1007 0 R >> endobj 1005 0 obj << /Count 1 /Dest [23 0 R /XYZ 72 134 null] /First 1006 0 R /Last 1006 0 R /Title (5. Bradley T, Peppa D, Pedroza-Pacheco I, Li D, Cain DW, Henao R, Venkat V, Hora B, Chen Y, Vandergrift NA, Overman RG, Edwards RW, Woods CW, Tomaras GD, Ferrari G, Ginsburg GS, Connors M, Cohen MS, Moody MA, Borrow P, Haynes BF. RAB11FIP5 expression and altered natural killer cell function are associated with induction of HIV broadly neutralizing antibody responses, Cell 2018 Oct 4;175\(2\):387-399e17. ) /Prev 1003 0 R /Parent 996 0 R /Next 1007 0 R >> endobj 1013 0 obj << /Dest [23 0 R /XYZ 90 85 null] /Title (Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion.) /Parent 1012 0 R >> endobj 1011 0 obj << /Dest [23 0 R /XYZ 72 85 null] /Title (7. Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A, Micco L, Nebbia G, Singh HD, Adams DH, Kennedy PT, Maini MK. ) /Parent 1010 0 R /Next 1012 0 R >> endobj 1012 0 obj << /Count 1 /Dest [23 0 R /XYZ 0 842 null] /First 1013 0 R /Last 1013 0 R /Title (Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion.) /Prev 1011 0 R /Parent 1010 0 R /Next 1014 0 R >> endobj 1014 0 obj << /Dest [23 0 R /XYZ 365 75 null] /Title ( J Exp Med. 2013 Jan 14;210\(1\):99-114. ) /Prev 1012 0 R /Parent 1010 0 R >> endobj 1010 0 obj << /Count 4 /Dest [23 0 R /XYZ 72 85 null] /First 1011 0 R /Last 1014 0 R /Title (7. Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A, Micco L, Nebbia G, Singh HD, Adams DH, Kennedy PT, Maini MK. ) /Parent 1009 0 R >> endobj 1007 0 obj << /Count 1 /Dest [23 0 R /XYZ 72 104 null] /First 1008 0 R /Last 1008 0 R /Title (6. Peppa D, Pedroza-Pacheco I, Pellegrino P, Williams I, Maini MK, Borrow P. Adaptive Reconfiguration of Natural Killer Cells in HIV-1 Infection. Front Immunol. 2018 Mar 16;9:474. ) /Prev 1005 0 R /Parent 996 0 R /Next 1009 0 R >> endobj 1009 0 obj << /Count 5 /Dest [23 0 R /XYZ 72 85 null] /First 1010 0 R /Last 1010 0 R /Title (7. Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A, Micco L, Nebbia G, Singh HD, Adams DH, Kennedy PT, Maini MK. ) /Prev 1007 0 R /Parent 996 0 R >> endobj 995 0 obj << /Dest [23 0 R /XYZ 72 254 null] /Title (Key Publications ) /Prev 994 0 R /Parent 343 0 R /Next 996 0 R >> endobj 996 0 obj << /Count 18 /Dest [23 0 R /XYZ 72 241 null] /First 997 0 R /Last 1009 0 R /Title (1. Touizer E, Alrubayyi A, Rees-Spear C, Fisher-Pearson N, Griffith S, Muir L, Pellegrino P, Waters L, Burns F, Kinloch S, Rowland-Jones S, Gupta K R, Gilosn R, Peppa D, McCoy L. Failure to seroconvert after two doses of BNT162b2 SARS-CoV-2 vaccine in uncontrolled HIV infection. Lancet HIV May 2021. ) /Prev 995 0 R /Parent 343 0 R /Next 1015 0 R >> endobj 1015 0 obj << /Dest [24 0 R /XYZ 72 783 null] /Title (Dr Anne M Pesenacker ) /Prev 996 0 R /Parent 343 0 R /Next 1016 0 R >> endobj 1019 0 obj << /Dest [24 0 R /XYZ 72 769 null] /Title (a.pesenacker@ucl.ac.uk) /Parent 1018 0 R >> endobj 1018 0 obj << /Count 1 /Dest [24 0 R /XYZ 0 842 null] /First 1019 0 R /Last 1019 0 R /Title (a.pesenacker@ucl.ac.uk) /Parent 1017 0 R /Next 1020 0 R >> endobj 1020 0 obj << /Dest [24 0 R /XYZ 72 769 null] /Title ( ) /Prev 1018 0 R /Parent 1017 0 R >> endobj 1016 0 obj << /Dest [24 0 R /XYZ 414 790 null] /Title (Figure) /Prev 1015 0 R /Parent 343 0 R /Next 1017 0 R >> endobj 1017 0 obj << /Count 3 /Dest [24 0 R /XYZ 0 842 null] /First 1018 0 R /Last 1020 0 R /Title (a.pesenacker@ucl.ac.uk) /Prev 1016 0 R /Parent 343 0 R /Next 1021 0 R >> endobj 1024 0 obj << /Dest [24 0 R /XYZ 72 742 null] /Title (https://iris.ucl.ac.uk/iris/browse/profile?upi=AMPES42) /Parent 1023 0 R >> endobj 1023 0 obj << /Count 1 /Dest [24 0 R /XYZ 0 842 null] /First 1024 0 R /Last 1024 0 R /Title (https://iris.ucl.ac.uk/iris/browse/profile?upi=AMPES42) /Parent 1022 0 R /Next 1025 0 R >> endobj 1025 0 obj << /Dest [24 0 R /XYZ 72 742 null] /Title ( ) /Prev 1023 0 R /Parent 1022 0 R >> endobj 1021 0 obj << /Dest [24 0 R /XYZ 72 755 null] /Title (Institute of Immunity and Transplantation, NW3 2PF ) /Prev 1017 0 R /Parent 343 0 R /Next 1022 0 R >> endobj 1022 0 obj << /Count 3 /Dest [24 0 R /XYZ 0 842 null] /First 1023 0 R /Last 1025 0 R /Title (https://iris.ucl.ac.uk/iris/browse/profile?upi=AMPES42) /Prev 1021 0 R /Parent 343 0 R /Next 1026 0 R >> endobj 1026 0 obj << /Dest [24 0 R /XYZ 72 728 null] /Title ( ) /Prev 1022 0 R /Parent 343 0 R /Next 1027 0 R >> endobj 1027 0 obj << /Dest [24 0 R /XYZ 72 713 null] /Title (Immune regulation via co-stimulatory, co-inhibitory receptors and regulatory T cells in health and autoimmunity ) /Prev 1026 0 R /Parent 343 0 R /Next 1028 0 R >> endobj 1028 0 obj << /Dest [24 0 R /XYZ 72 684 null] /Title ( ) /Prev 1027 0 R /Parent 343 0 R /Next 1029 0 R >> endobj 1029 0 obj << /Dest [24 0 R /XYZ 72 670 null] /Title (CD4+ Regulatory T cells \(Tregs\) are crucial to maintain tolerance, balancing effector T cell responses to harmful agents and suppressing unwanted responses. However, too little control may lead to autoimmunity \(e.g. juvenile idiopathic arthritis or type 1 diabetes\), while too much control may contribute to the development of cancers. Co-stimulatory and co-inhibitory receptors are crucial to determine functional outcomes upon activation. We are focussing on the relatively novel co-receptor family of CD96, CD) /Prev 1028 0 R /Parent 343 0 R /Next 1030 0 R >> endobj 1030 0 obj << /Dest [24 0 R /XYZ 72 549 null] /Title ( ) /Prev 1029 0 R /Parent 343 0 R /Next 1031 0 R >> endobj 1031 0 obj << /Dest [24 0 R /XYZ 72 539 null] /Title (Moreover, we currently lack Treg-specific markers and functional experiments are complex and may not represent in vivo activity. Therefore, we have established a clinically-applicable Treg gene signature that reflects Treg \215fitness\216 as a possible biomarker assay and to help us understand how Tregs are dysfunctional at the site of inflammation. A full PhD project with the studies being extended and would likely focus on the mechanistic basis behind altered Treg fitness in disease ) /Prev 1030 0 R /Parent 343 0 R /Next 1032 0 R >> endobj 1032 0 obj << /Dest [24 0 R /XYZ 72 473 null] /Title ( ) /Prev 1031 0 R /Parent 343 0 R /Next 1033 0 R >> endobj 1033 0 obj << /Dest [24 0 R /XYZ 72 462 null] /Title (The Pesenacker lab is using cellular and molecular immunology techniques, including the cutting-edge gene-editing system CRISPR-Cas9, cloning, cell culture, primary Treg expansion and editing, advanced flow cytometry, confocal microscopy and nanoString analysis, including biomarker discovery pipeline. ) /Prev 1032 0 R /Parent 343 0 R /Next 1034 0 R >> endobj 1034 0 obj << /Dest [24 0 R /XYZ 72 422 null] /Title ( ) /Prev 1033 0 R /Parent 343 0 R /Next 1035 0 R >> endobj 1035 0 obj << /Dest [24 0 R /XYZ 72 408 null] /Title (Details of potential Projects ) /Prev 1034 0 R /Parent 343 0 R /Next 1036 0 R >> endobj 1036 0 obj << /Dest [24 0 R /XYZ 79 395 null] /Title (CD96, CD226 and TIGIT co-receptor family as immune regulators ) /Prev 1035 0 R /Parent 343 0 R /Next 1037 0 R >> endobj 1037 0 obj << /Dest [24 0 R /XYZ 86 382 null] /Title (-> functional differences between CD96 variants ) /Prev 1036 0 R /Parent 343 0 R /Next 1038 0 R >> endobj 1038 0 obj << /Dest [24 0 R /XYZ 86 368 null] /Title (-> receptor-receptor-ligand interaction ) /Prev 1037 0 R /Parent 343 0 R /Next 1039 0 R >> endobj 1039 0 obj << /Dest [24 0 R /XYZ 86 355 null] /Title (-> co-receptor intracellular receptor trafficking/signalling upon ligation ) /Prev 1038 0 R /Parent 343 0 R /Next 1040 0 R >> endobj 1040 0 obj << /Dest [24 0 R /XYZ 86 341 null] /Title (-> role of co-receptors in Treg function ) /Prev 1039 0 R /Parent 343 0 R /Next 1041 0 R >> endobj 1041 0 obj << /Dest [24 0 R /XYZ 79 328 null] /Title (Treg gene signature as measure of Treg fitness ) /Prev 1040 0 R /Parent 343 0 R /Next 1042 0 R >> endobj 1042 0 obj << /Dest [24 0 R /XYZ 86 314 null] /Title (-> utilizing the Treg gene signature as biomarker for disease activity ) /Prev 1041 0 R /Parent 343 0 R /Next 1043 0 R >> endobj 1043 0 obj << /Dest [24 0 R /XYZ 86 301 null] /Title (-> understanding how the Treg signature genes define Treg fitness functionally ) /Prev 1042 0 R /Parent 343 0 R /Next 1044 0 R >> endobj 1044 0 obj << /Dest [24 0 R /XYZ 86 288 null] /Title (-> can Treg-targeted therapeutic approaches re-set the Treg gene signature? ) /Prev 1043 0 R /Parent 343 0 R /Next 1045 0 R >> endobj 1045 0 obj << /Dest [24 0 R /XYZ 72 274 null] /Title ( ) /Prev 1044 0 R /Parent 343 0 R /Next 1046 0 R >> endobj 1046 0 obj << /Dest [24 0 R /XYZ 72 261 null] /Title (Notably, any project will directly contribute to ongoing work in the Pesenacker lab and therefore holds the potential for co-authorship of any resulting publication. For more information, do not hesitate to contact Anne. ) /Prev 1045 0 R /Parent 343 0 R /Next 1047 0 R >> endobj 1047 0 obj << /Dest [24 0 R /XYZ 72 220 null] /Title ( ) /Prev 1046 0 R /Parent 343 0 R /Next 1048 0 R >> endobj 1051 0 obj << /Dest [24 0 R /XYZ 79 195 null] /Title (- Pesenacker AM, et al. \(2021\) Using crispr-cas9 to elucidate the role of TNF-receptors in Treg function. In preparation. ) /Parent 1050 0 R >> endobj 1053 0 obj << /Dest [24 0 R /XYZ 79 170 null] /Title (- Hoeppli RE, and Pesenacker AM. Targeting Tregs in Juvenile Idiopathic Arthritis and Juvenile Dermatomyositis-Insights From Other Diseases. Front Immunol. 2019;10:46. ) /Parent 1052 0 R >> endobj 1050 0 obj << /Count 1 /Dest [24 0 R /XYZ 79 195 null] /First 1051 0 R /Last 1051 0 R /Title (- Pesenacker AM, et al. \(2021\) Using crispr-cas9 to elucidate the role of TNF-receptors in Treg function. In preparation. ) /Parent 1049 0 R /Next 1052 0 R >> endobj 1055 0 obj << /Dest [24 0 R /XYZ 79 146 null] /Title (- Pesenacker AM, et al. Treg gene signatures predict and measure type 1 diabetes trajectory. JCI insight. 2019;4\(6\). ) /Parent 1054 0 R >> endobj 1052 0 obj << /Count 1 /Dest [24 0 R /XYZ 79 170 null] /First 1053 0 R /Last 1053 0 R /Title (- Hoeppli RE, and Pesenacker AM. Targeting Tregs in Juvenile Idiopathic Arthritis and Juvenile Dermatomyositis-Insights From Other Diseases. Front Immunol. 2019;10:46. ) /Prev 1050 0 R /Parent 1049 0 R /Next 1054 0 R >> endobj 1057 0 obj << /Dest [24 0 R /XYZ 79 121 null] /Title (- Pesenacker AM, et al. A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes. Diabetes. 2016;65\(4\):1031-9. ) /Parent 1056 0 R >> endobj 1054 0 obj << /Count 1 /Dest [24 0 R /XYZ 79 146 null] /First 1055 0 R /Last 1055 0 R /Title (- Pesenacker AM, et al. Treg gene signatures predict and measure type 1 diabetes trajectory. JCI insight. 2019;4\(6\). ) /Prev 1052 0 R /Parent 1049 0 R /Next 1056 0 R >> endobj 1059 0 obj << /Dest [24 0 R /XYZ 79 97 null] /Title (- Lam, AJ et al. Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity. Cell reports 36, 109494 \(2021\). ) /Parent 1058 0 R >> endobj 1056 0 obj << /Count 1 /Dest [24 0 R /XYZ 79 121 null] /First 1057 0 R /Last 1057 0 R /Title (- Pesenacker AM, et al. A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes. Diabetes. 2016;65\(4\):1031-9. ) /Prev 1054 0 R /Parent 1049 0 R /Next 1058 0 R >> endobj 1058 0 obj << /Count 1 /Dest [24 0 R /XYZ 79 97 null] /First 1059 0 R /Last 1059 0 R /Title (- Lam, AJ et al. Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity. Cell reports 36, 109494 \(2021\). ) /Prev 1056 0 R /Parent 1049 0 R >> endobj 1048 0 obj << /Dest [24 0 R /XYZ 72 207 null] /Title (Key publications: ) /Prev 1047 0 R /Parent 343 0 R /Next 1049 0 R >> endobj 1049 0 obj << /Count 10 /Dest [24 0 R /XYZ 79 195 null] /First 1050 0 R /Last 1058 0 R /Title (- Pesenacker AM, et al. \(2021\) Using crispr-cas9 to elucidate the role of TNF-receptors in Treg function. In preparation. ) /Prev 1048 0 R /Parent 343 0 R /Next 1060 0 R >> endobj 1060 0 obj << /Dest [25 0 R /XYZ 72 783 null] /Title (Dr Matthew Reeves ) /Prev 1049 0 R /Parent 343 0 R /Next 1061 0 R >> endobj 1064 0 obj << /Dest [25 0 R /XYZ 72 768 null] /Title (matthew.reeves@ucl.ac.uk) /Parent 1063 0 R >> endobj 1063 0 obj << /Count 1 /Dest [25 0 R /XYZ 0 842 null] /First 1064 0 R /Last 1064 0 R /Title (matthew.reeves@ucl.ac.uk) /Parent 1062 0 R /Next 1065 0 R >> endobj 1065 0 obj << /Dest [25 0 R /XYZ 72 768 null] /Title ( ) /Prev 1063 0 R /Parent 1062 0 R >> endobj 1061 0 obj << /Dest [25 0 R /XYZ 399 785 null] /Title (Figure) /Prev 1060 0 R /Parent 343 0 R /Next 1062 0 R >> endobj 1062 0 obj << /Count 3 /Dest [25 0 R /XYZ 0 842 null] /First 1063 0 R /Last 1065 0 R /Title (matthew.reeves@ucl.ac.uk) /Prev 1061 0 R /Parent 343 0 R /Next 1066 0 R >> endobj 1069 0 obj << /Dest [25 0 R /XYZ 72 739 null] /Title (/infection-immunity/people/dr-matthew-reeves) /Parent 1068 0 R >> endobj 1068 0 obj << /Count 1 /Dest [25 0 R /XYZ 0 842 null] /First 1069 0 R /Last 1069 0 R /Title (/infection-immunity/people/dr-matthew-reeves) /Parent 1067 0 R /Next 1070 0 R >> endobj 1070 0 obj << /Dest [25 0 R /XYZ 72 724 null] /Title ( ) /Prev 1068 0 R /Parent 1067 0 R >> endobj 1066 0 obj << /Dest [25 0 R /XYZ 72 754 null] /Title ( ) /Prev 1062 0 R /Parent 343 0 R /Next 1067 0 R >> endobj 1067 0 obj << /Count 3 /Dest [25 0 R /XYZ 0 842 null] /First 1068 0 R /Last 1070 0 R /Title (/infection-immunity/people/dr-matthew-reeves) /Prev 1066 0 R /Parent 343 0 R /Next 1071 0 R >> endobj 1071 0 obj << /Dest [25 0 R /XYZ 72 710 null] /Title ( ) /Prev 1067 0 R /Parent 343 0 R /Next 1072 0 R >> endobj 1072 0 obj << /Dest [25 0 R /XYZ 72 695 null] /Title (Molecular basis of human cytomegalovirus pathogenesis ) /Prev 1071 0 R /Parent 343 0 R /Next 1073 0 R >> endobj 1073 0 obj << /Dest [25 0 R /XYZ 72 667 null] /Title (Our research concentrates on the mechanisms human cytomegalovirus \(HCMV\) employs to promote, sustain and reactivate lifelong latent infections of the host. As obligate parasites, viruses must usurp, disable or re-prioritise key cellular processes for their own replication and survival and thus we investigate the molecular details of the interaction of HCMV with the host cell. In addition, we are interested how the interaction of HCMV with the cell impacts on immune surveillance. Thus, we take a mechanistic ) /Prev 1072 0 R /Parent 343 0 R /Next 1074 0 R >> endobj 1074 0 obj << /Dest [25 0 R /XYZ 72 541 null] /Title (Our current areas of interest include: ) /Prev 1073 0 R /Parent 343 0 R /Next 1075 0 R >> endobj 1075 0 obj << /Dest [25 0 R /XYZ 72 527 null] /Title ( ) /Prev 1074 0 R /Parent 343 0 R /Next 1076 0 R >> endobj 1076 0 obj << /Dest [25 0 R /XYZ 72 513 null] /Title (Defining the contribution of cellular signalling pathways to HCMV infection. Viral reactivation is dependent on host cell signaling on host cell identity. We are interested in defining the importance of these pathways for HCMV reactivation and, additionally, why dendritic cells are important for this process. The overall aim is to foster a deeper understanding of cellular signalling pathways, how they impact on HCMV biology and, ultimately, how the manipulation of these pathways could be a therapeutic strat) /Prev 1075 0 R /Parent 343 0 R /Next 1077 0 R >> endobj 1077 0 obj << /Dest [25 0 R /XYZ 72 428 null] /Title ( ) /Prev 1076 0 R /Parent 343 0 R /Next 1078 0 R >> endobj 1078 0 obj << /Dest [25 0 R /XYZ 72 414 null] /Title (The contribution of cellular factors to the establishment of latency. We have recently identified a discrete set of cellular encoded miRNAs that are differentially regulated in the very early stages of HCMV latent infection. It is clear from our previous work that, in order to establish a latent infection, HCMV successfully counters a hostile cellular environment via manipulation of host cell signalling. Thus future projects will seek to determine the contribution miRNAs \205 which represent highly sensitive r) /Prev 1077 0 R /Parent 343 0 R /Next 1079 0 R >> endobj 1079 0 obj << /Dest [25 0 R /XYZ 72 316 null] /Title ( ) /Prev 1078 0 R /Parent 343 0 R /Next 1080 0 R >> endobj 1084 0 obj << /Dest [25 0 R /XYZ 241 218 null] /Title (www.reevescmvlab.com) /Parent 1083 0 R >> endobj 1082 0 obj << /Dest [25 0 R /XYZ 72 218 null] /Title (More about the lab can be found at ) /Parent 1081 0 R /Next 1083 0 R >> endobj 1083 0 obj << /Count 1 /Dest [25 0 R /XYZ 0 842 null] /First 1084 0 R /Last 1084 0 R /Title (www.reevescmvlab.com) /Prev 1082 0 R /Parent 1081 0 R /Next 1085 0 R >> endobj 1085 0 obj << /Dest [25 0 R /XYZ 241 218 null] /Title ( ) /Prev 1083 0 R /Parent 1081 0 R >> endobj 1080 0 obj << /Dest [25 0 R /XYZ 72 302 null] /Title (The immune response to HCMV and vaccination. HCMV dedicates over 40% of its 230kb genome to immune evasion strategies \205 enabling it to counter a prodigious host immune response. We are interested in the aspects of that response which are potently anti-viral to learn more about the control of chronic infections in vivo and help guide our ongoing efforts to develop an urgently needed vaccine against HCMV. ) /Prev 1079 0 R /Parent 343 0 R /Next 1081 0 R >> endobj 1081 0 obj << /Count 4 /Dest [25 0 R /XYZ 72 218 null] /First 1082 0 R /Last 1085 0 R /Title (More about the lab can be found at ) /Prev 1080 0 R /Parent 343 0 R /Next 1086 0 R >> endobj 1086 0 obj << /Dest [25 0 R /XYZ 72 190 null] /Title (Recent and key publications from the lab ) /Prev 1081 0 R /Parent 343 0 R /Next 1087 0 R >> endobj 1087 0 obj << /Dest [25 0 R /XYZ 72 177 null] /Title (Mason et al \(2023\) J. Gen. Virol. 104\(9\) ) /Prev 1086 0 R /Parent 343 0 R /Next 1088 0 R >> endobj 1088 0 obj << /Dest [25 0 R /XYZ 72 164 null] /Title (Gomes A. et al \(2023\) J. Gen. Virol. 104\(6\) ) /Prev 1087 0 R /Parent 343 0 R /Next 1089 0 R >> endobj 1089 0 obj << /Dest [25 0 R /XYZ 72 152 null] /Title (Murray M. et al \(2023\) J. Biol. Chem. 299\(6\):104727 ) /Prev 1088 0 R /Parent 343 0 R /Next 1090 0 R >> endobj 1090 0 obj << /Dest [25 0 R /XYZ 72 140 null] /Title (Forrest C. et al \(2023\) Nature Comms. 14\(1\):1409 ) /Prev 1089 0 R /Parent 343 0 R /Next 1091 0 R >> endobj 1091 0 obj << /Dest [25 0 R /XYZ 72 128 null] /Title (Gomes A. et al \(2023\) Nature Comms. 14\(1\):1041 ) /Prev 1090 0 R /Parent 343 0 R /Next 1092 0 R >> endobj 1092 0 obj << /Dest [25 0 R /XYZ 72 116 null] /Title (Mason R et al \(2020\) J. Gen. Virol. 101\(6\):635-44 ) /Prev 1091 0 R /Parent 343 0 R /Next 1093 0 R >> endobj 1093 0 obj << /Dest [25 0 R /XYZ 473 179 null] /Title (Murray M.J. et al \(2020\) J. Virol. 94 \(7\):e02012-19 ) /Prev 1092 0 R /Parent 343 0 R /Next 1094 0 R >> endobj 1094 0 obj << /Dest [25 0 R /XYZ 497 167 null] /Title (Baraniak, I. et al \(2019\) Lancet EBioMedicine 50:45-54 ) /Prev 1093 0 R /Parent 343 0 R /Next 1095 0 R >> endobj 1095 0 obj << /Dest [25 0 R /XYZ 460 142 null] /Title (Dupont L. et al \(2019\) J. Biol. Chem. 294\(35\):12901-1291 ) /Prev 1094 0 R /Parent 343 0 R /Next 1096 0 R >> endobj 1096 0 obj << /Dest [25 0 R /XYZ 315 116 null] /Title (Baraniak I. et al \(2019\) J. Inf. Dis. 220\(2\):228-232 ) /Prev 1095 0 R /Parent 343 0 R /Next 1097 0 R >> endobj 1097 0 obj << /Dest [25 0 R /XYZ 72 103 null] /Title (Poole E.L. et al \(2018\) Cell Reports 24\(3\):594-606 ) /Prev 1096 0 R /Parent 343 0 R /Next 1098 0 R >> endobj 1098 0 obj << /Dest [25 0 R /XYZ 315 103 null] /Title (Baraniak I et al \(2018\) PNAS 115\(24\):6273-6278 ) /Prev 1097 0 R /Parent 343 0 R /Next 1099 0 R >> endobj 1099 0 obj << /Dest [25 0 R /XYZ 72 91 null] /Title ( ) /Prev 1098 0 R /Parent 343 0 R /Next 1100 0 R >> endobj 1100 0 obj << /Dest [26 0 R /XYZ 72 783 null] /Title (Prof David Sansom ) /Prev 1099 0 R /Parent 343 0 R /Next 1101 0 R >> endobj 1104 0 obj << /Dest [26 0 R /XYZ 72 768 null] /Title (d.sansom@ucl.ac.uk) /Parent 1103 0 R >> endobj 1103 0 obj << /Count 1 /Dest [26 0 R /XYZ 0 842 null] /First 1104 0 R /Last 1104 0 R /Title (d.sansom@ucl.ac.uk) /Parent 1102 0 R /Next 1105 0 R >> endobj 1105 0 obj << /Dest [26 0 R /XYZ 72 768 null] /Title ( ) /Prev 1103 0 R /Parent 1102 0 R >> endobj 1101 0 obj << /Dest [26 0 R /XYZ 416 785 null] /Title (Figure) /Prev 1100 0 R /Parent 343 0 R /Next 1102 0 R >> endobj 1102 0 obj << /Count 3 /Dest [26 0 R /XYZ 0 842 null] /First 1103 0 R /Last 1105 0 R /Title (d.sansom@ucl.ac.uk) /Prev 1101 0 R /Parent 343 0 R /Next 1106 0 R >> endobj 1109 0 obj << /Dest [26 0 R /XYZ 72 739 null] /Title (/infection-immunity/people/professor-david-sansom) /Parent 1108 0 R >> endobj 1108 0 obj << /Count 1 /Dest [26 0 R /XYZ 0 842 null] /First 1109 0 R /Last 1109 0 R /Title (/infection-immunity/people/professor-david-sansom) /Parent 1107 0 R /Next 1110 0 R >> endobj 1110 0 obj << /Dest [26 0 R /XYZ 72 724 null] /Title ( ) /Prev 1108 0 R /Parent 1107 0 R >> endobj 1106 0 obj << /Dest [26 0 R /XYZ 72 754 null] /Title ( ) /Prev 1102 0 R /Parent 343 0 R /Next 1107 0 R >> endobj 1107 0 obj << /Count 3 /Dest [26 0 R /XYZ 0 842 null] /First 1108 0 R /Last 1110 0 R /Title (/infection-immunity/people/professor-david-sansom) /Prev 1106 0 R /Parent 343 0 R /Next 1111 0 R >> endobj 1111 0 obj << /Dest [26 0 R /XYZ 72 710 null] /Title ( ) /Prev 1107 0 R /Parent 343 0 R /Next 1112 0 R >> endobj 1112 0 obj << /Dest [26 0 R /XYZ 72 695 null] /Title (Understanding the CD28/CTLA-4 pathway in the control of T cell responses ) /Prev 1111 0 R /Parent 343 0 R /Next 1113 0 R >> endobj 1113 0 obj << /Dest [26 0 R /XYZ 72 666 null] /Title ( ) /Prev 1112 0 R /Parent 343 0 R /Next 1114 0 R >> endobj 1114 0 obj << /Dest [26 0 R /XYZ 72 652 null] /Title (The adaptive immune response \(T cells and B cells\) provides long lasting specific protection against constantly evolving pathogens. This requires a vast array of receptors \(TCR and BCR\) to be generated to cover all possible pathogens and is achieved by randomly generating millions of highly diverse receptors. The downside to this process is that receptors can be generated that are capable of recognizing our own tissues resulting in autoimmune diseases. The CD28/ CTLA-4 pathway is involved in preventing this) /Prev 1113 0 R /Parent 343 0 R /Next 1115 0 R >> endobj 1115 0 obj << /Dest [26 0 R /XYZ 72 554 null] /Title ( ) /Prev 1114 0 R /Parent 343 0 R /Next 1116 0 R >> endobj 1116 0 obj << /Dest [26 0 R /XYZ 72 540 null] /Title (The Sansom Lab works on understanding the molecular and cellular mechanisms of CD28/ CTLA-4 function and the impact of their mutation in disease. The CD28/ CTLA-4 pathway consists of a stimulatory receptor \(CD28\) and an inhibitory receptor \(CTLA-4\), which bind to two shared ligands with varying affinities. My lab discovered a new biological process \(transendocytosis\) whereby CTLA-4 effectively captures and destroys the ligands, which stimulate CD28. This mechanism is used by regulatory T cells to suppress) /Prev 1115 0 R /Parent 343 0 R /Next 1117 0 R >> endobj 1117 0 obj << /Dest [26 0 R /XYZ 72 400 null] /Title ( ) /Prev 1116 0 R /Parent 343 0 R /Next 1118 0 R >> endobj 1118 0 obj << /Dest [26 0 R /XYZ 72 386 null] /Title (Potential PhD project areas include: ) /Prev 1117 0 R /Parent 343 0 R /Next 1119 0 R >> endobj 1119 0 obj << /Dest [26 0 R /XYZ 72 372 null] /Title (1\). Studying the impact of patient-derived mutations in CTLA-4, CD80 and CD86 pathways. ) /Prev 1118 0 R /Parent 343 0 R /Next 1120 0 R >> endobj 1120 0 obj << /Dest [26 0 R /XYZ 72 358 null] /Title (2\). Investigating the differential functions of CD80 and CD86 in immune responses. ) /Prev 1119 0 R /Parent 343 0 R /Next 1121 0 R >> endobj 1121 0 obj << /Dest [26 0 R /XYZ 72 343 null] /Title (3\). Understanding the molecular mechanism of Transendocytosis. ) /Prev 1120 0 R /Parent 343 0 R /Next 1122 0 R >> endobj 1122 0 obj << /Dest [26 0 R /XYZ 72 330 null] /Title ( ) /Prev 1121 0 R /Parent 343 0 R /Next 1123 0 R >> endobj 1126 0 obj << /Dest [26 0 R /XYZ 90 302 null] /Title (\200 Qureshi, O.S., et al. \(2011\). Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332, 600-603. ) /Parent 1125 0 R >> endobj 1128 0 obj << /Dest [26 0 R /XYZ 90 274 null] /Title (\200 Schubert, D., et al. \(2014\). Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nature Medicine 20, 1410-1416. ) /Parent 1127 0 R >> endobj 1125 0 obj << /Count 1 /Dest [26 0 R /XYZ 90 302 null] /First 1126 0 R /Last 1126 0 R /Title (\200 Qureshi, O.S., et al. \(2011\). Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332, 600-603. ) /Parent 1124 0 R /Next 1127 0 R >> endobj 1130 0 obj << /Dest [26 0 R /XYZ 90 247 null] /Title (\200 Soskic, B., et.al., \(2014\). A Transendocytosis Perspective on the CD28/CTLA-4 Pathway. Adv Immunol 124, 95-136. ) /Parent 1129 0 R >> endobj 1127 0 obj << /Count 1 /Dest [26 0 R /XYZ 90 274 null] /First 1128 0 R /Last 1128 0 R /Title (\200 Schubert, D., et al. \(2014\). Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nature Medicine 20, 1410-1416. ) /Prev 1125 0 R /Parent 1124 0 R /Next 1129 0 R >> endobj 1132 0 obj << /Dest [26 0 R /XYZ 90 219 null] /Title (\200 Walker, L.S., and Sansom, D.M. \(2015\). Confusing signals: Recent progress in CTLA-4 biology. Trends in immunology 36, 63-70. ) /Parent 1131 0 R >> endobj 1129 0 obj << /Count 1 /Dest [26 0 R /XYZ 90 247 null] /First 1130 0 R /Last 1130 0 R /Title (\200 Soskic, B., et.al., \(2014\). A Transendocytosis Perspective on the CD28/CTLA-4 Pathway. Adv Immunol 124, 95-136. ) /Prev 1127 0 R /Parent 1124 0 R /Next 1131 0 R >> endobj 1134 0 obj << /Dest [26 0 R /XYZ 90 192 null] /Title (\200 Hou, T.Z. et.al.,\(2015\). A Transendocytosis model of CTLA-4 function predicts its suppressive behaviour on regulatory T cells. J Immunol 194, 2148-2159. ) /Parent 1133 0 R >> endobj 1131 0 obj << /Count 1 /Dest [26 0 R /XYZ 90 219 null] /First 1132 0 R /Last 1132 0 R /Title (\200 Walker, L.S., and Sansom, D.M. \(2015\). Confusing signals: Recent progress in CTLA-4 biology. Trends in immunology 36, 63-70. ) /Prev 1129 0 R /Parent 1124 0 R /Next 1133 0 R >> endobj 1136 0 obj << /Dest [26 0 R /XYZ 90 164 null] /Title (\200 Sansom, D.M. \(2015\). Moving CTLA-4 from the trash to recycling. Science 349, 377-378. ) /Parent 1135 0 R >> endobj 1133 0 obj << /Count 1 /Dest [26 0 R /XYZ 90 192 null] /First 1134 0 R /Last 1134 0 R /Title (\200 Hou, T.Z. et.al.,\(2015\). A Transendocytosis model of CTLA-4 function predicts its suppressive behaviour on regulatory T cells. J Immunol 194, 2148-2159. ) /Prev 1131 0 R /Parent 1124 0 R /Next 1135 0 R >> endobj 1135 0 obj << /Count 1 /Dest [26 0 R /XYZ 90 164 null] /First 1136 0 R /Last 1136 0 R /Title (\200 Sansom, D.M. \(2015\). Moving CTLA-4 from the trash to recycling. Science 349, 377-378. ) /Prev 1133 0 R /Parent 1124 0 R >> endobj 1123 0 obj << /Dest [26 0 R /XYZ 72 316 null] /Title (References ) /Prev 1122 0 R /Parent 343 0 R /Next 1124 0 R >> endobj 1124 0 obj << /Count 12 /Dest [26 0 R /XYZ 90 302 null] /First 1125 0 R /Last 1135 0 R /Title (\200 Qureshi, O.S., et al. \(2011\). Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332, 600-603. ) /Prev 1123 0 R /Parent 343 0 R /Next 1137 0 R >> endobj 1137 0 obj << /Dest [26 0 R /XYZ 72 151 null] /Title ( ) /Prev 1124 0 R /Parent 343 0 R /Next 1138 0 R >> endobj 1138 0 obj << /Dest [26 0 R /XYZ 72 138 null] /Title ( ) /Prev 1137 0 R /Parent 343 0 R /Next 1139 0 R >> endobj 1139 0 obj << /Dest [26 0 R /XYZ 72 124 null] /Title ( ) /Prev 1138 0 R /Parent 343 0 R /Next 1140 0 R >> endobj 1140 0 obj << /Dest [26 0 R /XYZ 72 110 null] /Title ( ) /Prev 1139 0 R /Parent 343 0 R /Next 1141 0 R >> endobj 1141 0 obj << /Dest [26 0 R /XYZ 72 96 null] /Title ( ) /Prev 1140 0 R /Parent 343 0 R /Next 1142 0 R >> endobj 1142 0 obj << /Dest [26 0 R /XYZ 523 81 null] /Title ( ) /Prev 1141 0 R /Parent 343 0 R /Next 1143 0 R >> endobj 1143 0 obj << /Dest [27 0 R /XYZ 72 783 null] /Title (Prof Benedict Seddon ) /Prev 1142 0 R /Parent 343 0 R /Next 1144 0 R >> endobj 1147 0 obj << /Dest [27 0 R /XYZ 72 768 null] /Title (benedict.seddon@ucl.ac.uk) /Parent 1146 0 R >> endobj 1146 0 obj << /Count 1 /Dest [27 0 R /XYZ 0 842 null] /First 1147 0 R /Last 1147 0 R /Title (benedict.seddon@ucl.ac.uk) /Parent 1145 0 R /Next 1148 0 R >> endobj 1148 0 obj << /Dest [27 0 R /XYZ 72 768 null] /Title ( ) /Prev 1146 0 R /Parent 1145 0 R >> endobj 1144 0 obj << /Dest [27 0 R /XYZ 404 784 null] /Title (Figure) /Prev 1143 0 R /Parent 343 0 R /Next 1145 0 R >> endobj 1145 0 obj << /Count 3 /Dest [27 0 R /XYZ 0 842 null] /First 1146 0 R /Last 1148 0 R /Title (benedict.seddon@ucl.ac.uk) /Prev 1144 0 R /Parent 343 0 R /Next 1149 0 R >> endobj 1152 0 obj << /Dest [27 0 R /XYZ 72 739 null] /Title (/infection-immunity/people/professor-benedict-seddon) /Parent 1151 0 R >> endobj 1151 0 obj << /Count 1 /Dest [27 0 R /XYZ 0 842 null] /First 1152 0 R /Last 1152 0 R /Title (/infection-immunity/people/professor-benedict-seddon) /Parent 1150 0 R /Next 1153 0 R >> endobj 1153 0 obj << /Dest [27 0 R /XYZ 72 724 null] /Title ( ) /Prev 1151 0 R /Parent 1150 0 R >> endobj 1149 0 obj << /Dest [27 0 R /XYZ 72 754 null] /Title ( ) /Prev 1145 0 R /Parent 343 0 R /Next 1150 0 R >> endobj 1150 0 obj << /Count 3 /Dest [27 0 R /XYZ 0 842 null] /First 1151 0 R /Last 1153 0 R /Title (/infection-immunity/people/professor-benedict-seddon) /Prev 1149 0 R /Parent 343 0 R /Next 1154 0 R >> endobj 1154 0 obj << /Dest [27 0 R /XYZ 72 710 null] /Title ( ) /Prev 1150 0 R /Parent 343 0 R /Next 1155 0 R >> endobj 1155 0 obj << /Dest [27 0 R /XYZ 72 695 null] /Title (Defining the cellular and molecular mechanisms controlling T cell immunity ) /Prev 1154 0 R /Parent 343 0 R /Next 1156 0 R >> endobj 1156 0 obj << /Dest [27 0 R /XYZ 72 667 null] /Title ( ) /Prev 1155 0 R /Parent 343 0 R /Next 1157 0 R >> endobj 1157 0 obj << /Dest [27 0 R /XYZ 72 653 null] /Title (The immune system has evolved specific homeostatic mechanisms to ensure that both the numbers and antigen-recognition receptor diversity of T cells are maintained at relatively constant levels for much of our lifetimes. There are many disease conditions, however, ranging from acquired or genetic immunodeficiencies, to autoimmune diseases and ageing, in which T cell homeostasis is disrupted. This can lead to lymphopenia, shifts in TCR repertoires, reduced responsiveness to vaccines, and increased susceptibil) /Prev 1156 0 R /Parent 343 0 R /Next 1158 0 R >> endobj 1158 0 obj << /Dest [27 0 R /XYZ 72 442 null] /Title ( ) /Prev 1157 0 R /Parent 343 0 R /Next 1159 0 R >> endobj 1159 0 obj << /Dest [27 0 R /XYZ 72 428 null] /Title (The PhD project will augment ongoing studies and provide training in molecular, cellular and/or computational immunology. The Seddon laboratory is located in the newly opened Institute of Immunity and Transplantation at the Royal Free Hospital, that offers state of the art facilities and training environment. The Seddon laboratory has an excellent track record of PhD student training - all students finish with one or more first author papers. ) /Prev 1158 0 R /Parent 343 0 R /Next 1160 0 R >> endobj 1160 0 obj << /Dest [27 0 R /XYZ 72 358 null] /Title ( ) /Prev 1159 0 R /Parent 343 0 R /Next 1161 0 R >> endobj 1161 0 obj << /Dest [27 0 R /XYZ 72 344 null] /Title (Example Papers from past PhD students \(in bold\) ) /Prev 1160 0 R /Parent 343 0 R /Next 1162 0 R >> endobj 1162 0 obj << /Dest [27 0 R /XYZ 72 330 null] /Title (Carty, F., S. Layzell, A. Barbarulo, F. Islam, L.V. Webb, and B. Seddon. 2023. IKK promotes naive T cell survival by repressing RIPK1-dependent apoptosis and activating NF-kappaB. Sci Signal 16:eabo4094. ) /Prev 1161 0 R /Parent 343 0 R /Next 1163 0 R >> endobj 1163 0 obj << /Dest [27 0 R /XYZ 72 303 null] /Title (Verheijen, M., S. Rane, C. Pearson, A.J. Yates, and B. Seddon. 2020. Fate Mapping Quantifies the Dynamics of B Cell Development and Activation throughout Life. Cell Rep 33:108376. ) /Prev 1162 0 R /Parent 343 0 R /Next 1164 0 R >> endobj 1164 0 obj << /Dest [27 0 R /XYZ 72 277 null] /Title /Prev 1163 0 R /Parent 343 0 R /Next 1165 0 R >> endobj 1165 0 obj << /Dest [27 0 R /XYZ 72 236 null] /Title (Webb, L.V., S.C. Ley, and B. Seddon. 2016. J Exp Med 213:1399-1407. ) /Prev 1164 0 R /Parent 343 0 R /Next 1166 0 R >> endobj 1166 0 obj << /Dest [27 0 R /XYZ 72 223 null] /Title (Schim van der Loeff, I., L.Y. Hsu, M. Saini, A. Weiss, and B. Seddon. 2014. J Immunol 193:2873-2880. ) /Prev 1165 0 R /Parent 343 0 R /Next 1167 0 R >> endobj 1167 0 obj << /Dest [27 0 R /XYZ 72 209 null] /Title (Marshall, D., C. Sinclair, S. Tung, and B. Seddon. 2014. J Immunol 193:5525-5533. ) /Prev 1166 0 R /Parent 343 0 R /Next 1168 0 R >> endobj 1168 0 obj << /Dest [27 0 R /XYZ 72 196 null] /Title (Sinclair, C., Bains, I., Yates, A. and B. Seddon 2013. PNAS. 110 \(31\), E2905-E2914 ) /Prev 1167 0 R /Parent 343 0 R /Next 1169 0 R >> endobj 1169 0 obj << /Dest [27 0 R /XYZ 72 183 null] /Title (Sinclair, C., Saini, M., van der Loeff, I.S., Sakaguchi, S., and Seddon, B. 2011. Sci Signal 4, ra77. ) /Prev 1168 0 R /Parent 343 0 R /Next 1170 0 R >> endobj 1170 0 obj << /Dest [27 0 R /XYZ 72 154 null] /Title ( ) /Prev 1169 0 R /Parent 343 0 R /Next 1171 0 R >> endobj 1171 0 obj << /Dest [27 0 R /XYZ 72 141 null] /Title ( ) /Prev 1170 0 R /Parent 343 0 R /Next 1172 0 R >> endobj 1172 0 obj << /Dest [28 0 R /XYZ 72 783 null] /Title (Prof Hans Stauss ) /Prev 1171 0 R /Parent 343 0 R /Next 1173 0 R >> endobj 1173 0 obj << /Dest [28 0 R /XYZ 416 780 null] /Title (Figure) /Prev 1172 0 R /Parent 343 0 R /Next 1174 0 R >> endobj 1177 0 obj << /Dest [28 0 R /XYZ 72 754 null] /Title (h.stauss@ucl.ac.uk) /Parent 1176 0 R >> endobj 1176 0 obj << /Count 1 /Dest [28 0 R /XYZ 0 842 null] /First 1177 0 R /Last 1177 0 R /Title (h.stauss@ucl.ac.uk) /Parent 1175 0 R /Next 1178 0 R >> endobj 1178 0 obj << /Dest [28 0 R /XYZ 72 754 null] /Title ( ) /Prev 1176 0 R /Parent 1175 0 R >> endobj 1174 0 obj << /Dest [28 0 R /XYZ 72 768 null] /Title ( ) /Prev 1173 0 R /Parent 343 0 R /Next 1175 0 R >> endobj 1175 0 obj << /Count 3 /Dest [28 0 R /XYZ 0 842 null] /First 1176 0 R /Last 1178 0 R /Title (h.stauss@ucl.ac.uk) /Prev 1174 0 R /Parent 343 0 R /Next 1179 0 R >> endobj 1182 0 obj << /Dest [28 0 R /XYZ 72 724 null] /Title (/infection-immunity/people/professor-hans-stauss) /Parent 1181 0 R >> endobj 1181 0 obj << /Count 1 /Dest [28 0 R /XYZ 0 842 null] /First 1182 0 R /Last 1182 0 R /Title (/infection-immunity/people/professor-hans-stauss) /Parent 1180 0 R /Next 1183 0 R >> endobj 1183 0 obj << /Dest [28 0 R /XYZ 72 710 null] /Title ( ) /Prev 1181 0 R /Parent 1180 0 R >> endobj 1179 0 obj << /Dest [28 0 R /XYZ 72 739 null] /Title ( ) /Prev 1175 0 R /Parent 343 0 R /Next 1180 0 R >> endobj 1180 0 obj << /Count 3 /Dest [28 0 R /XYZ 0 842 null] /First 1181 0 R /Last 1183 0 R /Title (/infection-immunity/people/professor-hans-stauss) /Prev 1179 0 R /Parent 343 0 R /Next 1184 0 R >> endobj 1184 0 obj << /Dest [28 0 R /XYZ 72 695 null] /Title ( ) /Prev 1180 0 R /Parent 343 0 R /Next 1185 0 R >> endobj 1185 0 obj << /Dest [28 0 R /XYZ 72 680 null] /Title ( ) /Prev 1184 0 R /Parent 343 0 R /Next 1186 0 R >> endobj 1186 0 obj << /Dest [28 0 R /XYZ 72 666 null] /Title ( ) /Prev 1185 0 R /Parent 343 0 R /Next 1187 0 R >> endobj 1187 0 obj << /Dest [28 0 R /XYZ 72 651 null] /Title (The main focus of our research is the analysis of antigen-specific T lymphocyte responses to tumours and the development of immunotherapy approaches for the treatment of cancer and chronic infection. In order to generate therapeutic T cells of desired specificity we use retroviral vectors to transfer the genes encoding antigen-specific T cell receptors \(TCR\) and chimeric antigen receptors \(CAR\) into primary T cells. We have developed strategies to improve the expression and function of therapeutic TCR, and ) /Prev 1186 0 R /Parent 343 0 R /Next 1188 0 R >> endobj 1188 0 obj << /Dest [28 0 R /XYZ 72 525 null] /Title ( ) /Prev 1187 0 R /Parent 343 0 R /Next 1189 0 R >> endobj 1189 0 obj << /Dest [28 0 R /XYZ 72 511 null] /Title (We also employ genetic engineering to regulate the metabolic activity of gene modified T cells, with the goal to either enhance effector T cell differentiation or memory formation in vivo. The CRISPR technology is used to perform targeted gene editing, which allows us to disrupt genes encoding proteins that are involved in triggering the exhaustion of therapeutic T cells. Finally, we have used the transfer of TCR and CAR into regulatory T cells to achieve antigen-specific immune suppression in vivo as poten) /Prev 1188 0 R /Parent 343 0 R /Next 1190 0 R >> endobj 1190 0 obj << /Dest [28 0 R /XYZ 72 426 null] /Title ( ) /Prev 1189 0 R /Parent 343 0 R /Next 1191 0 R >> endobj 1191 0 obj << /Dest [28 0 R /XYZ 72 412 null] /Title ( ) /Prev 1190 0 R /Parent 343 0 R /Next 1192 0 R >> endobj 1192 0 obj << /Dest [28 0 R /XYZ 72 397 null] /Title ( ) /Prev 1191 0 R /Parent 343 0 R /Next 1193 0 R >> endobj 1193 0 obj << /Dest [28 0 R /XYZ 72 382 null] /Title ( ) /Prev 1192 0 R /Parent 343 0 R /Next 1194 0 R >> endobj 1194 0 obj << /Dest [28 0 R /XYZ 72 368 null] /Title ( ) /Prev 1193 0 R /Parent 343 0 R /Next 1195 0 R >> endobj 1195 0 obj << /Dest [28 0 R /XYZ 72 353 null] /Title ( ) /Prev 1194 0 R /Parent 343 0 R /Next 1196 0 R >> endobj 1196 0 obj << /Dest [28 0 R /XYZ 72 339 null] /Title ( ) /Prev 1195 0 R /Parent 343 0 R /Next 1197 0 R >> endobj 1197 0 obj << /Dest [28 0 R /XYZ 72 324 null] /Title ( ) /Prev 1196 0 R /Parent 343 0 R /Next 1198 0 R >> endobj 1198 0 obj << /Dest [28 0 R /XYZ 72 309 null] /Title ( ) /Prev 1197 0 R /Parent 343 0 R /Next 1199 0 R >> endobj 1199 0 obj << /Dest [28 0 R /XYZ 72 295 null] /Title ( ) /Prev 1198 0 R /Parent 343 0 R /Next 1200 0 R >> endobj 1200 0 obj << /Dest [28 0 R /XYZ 72 280 null] /Title ( ) /Prev 1199 0 R /Parent 343 0 R /Next 1201 0 R >> endobj 1201 0 obj << /Dest [28 0 R /XYZ 72 265 null] /Title ( ) /Prev 1200 0 R /Parent 343 0 R /Next 1202 0 R >> endobj 1202 0 obj << /Dest [28 0 R /XYZ 72 251 null] /Title ( ) /Prev 1201 0 R /Parent 343 0 R /Next 1203 0 R >> endobj 1203 0 obj << /Dest [28 0 R /XYZ 72 236 null] /Title ( ) /Prev 1202 0 R /Parent 343 0 R /Next 1204 0 R >> endobj 1204 0 obj << /Dest [28 0 R /XYZ 72 221 null] /Title ( ) /Prev 1203 0 R /Parent 343 0 R /Next 1205 0 R >> endobj 1205 0 obj << /Dest [28 0 R /XYZ 72 207 null] /Title ( ) /Prev 1204 0 R /Parent 343 0 R /Next 1206 0 R >> endobj 1206 0 obj << /Dest [28 0 R /XYZ 72 192 null] /Title ( ) /Prev 1205 0 R /Parent 343 0 R /Next 1207 0 R >> endobj 1207 0 obj << /Dest [28 0 R /XYZ 72 177 null] /Title ( ) /Prev 1206 0 R /Parent 343 0 R /Next 1208 0 R >> endobj 1208 0 obj << /Dest [28 0 R /XYZ 72 163 null] /Title ( ) /Prev 1207 0 R /Parent 343 0 R /Next 1209 0 R >> endobj 1209 0 obj << /Dest [28 0 R /XYZ 72 148 null] /Title ( ) /Prev 1208 0 R /Parent 343 0 R /Next 1210 0 R >> endobj 1210 0 obj << /Dest [28 0 R /XYZ 72 133 null] /Title ( ) /Prev 1209 0 R /Parent 343 0 R /Next 1211 0 R >> endobj 1211 0 obj << /Dest [28 0 R /XYZ 72 119 null] /Title ( ) /Prev 1210 0 R /Parent 343 0 R /Next 1212 0 R >> endobj 1212 0 obj << /Dest [28 0 R /XYZ 72 104 null] /Title ( ) /Prev 1211 0 R /Parent 343 0 R /Next 1213 0 R >> endobj 1213 0 obj << /Dest [28 0 R /XYZ 72 90 null] /Title ( ) /Prev 1212 0 R /Parent 343 0 R /Next 1214 0 R >> endobj 1214 0 obj << /Dest [28 0 R /XYZ 72 75 null] /Title ( ) /Prev 1213 0 R /Parent 343 0 R /Next 1215 0 R >> endobj 1215 0 obj << /Dest [29 0 R /XYZ 72 783 null] /Title (Dr Leo Swadling ) /Prev 1214 0 R /Parent 343 0 R /Next 1216 0 R >> endobj 1219 0 obj << /Dest [29 0 R /XYZ 72 768 null] /Title (l.swadling@ucl.ac.uk) /Parent 1218 0 R >> endobj 1218 0 obj << /Count 1 /Dest [29 0 R /XYZ 0 842 null] /First 1219 0 R /Last 1219 0 R /Title (l.swadling@ucl.ac.uk) /Parent 1217 0 R /Next 1220 0 R >> endobj 1220 0 obj << /Dest [29 0 R /XYZ 72 768 null] /Title ( ) /Prev 1218 0 R /Parent 1217 0 R >> endobj 1216 0 obj << /Dest [29 0 R /XYZ 429 781 null] /Title (Figure) /Prev 1215 0 R /Parent 343 0 R /Next 1217 0 R >> endobj 1217 0 obj << /Count 3 /Dest [29 0 R /XYZ 0 842 null] /First 1218 0 R /Last 1220 0 R /Title (l.swadling@ucl.ac.uk) /Prev 1216 0 R /Parent 343 0 R /Next 1221 0 R >> endobj 1225 0 obj << /Dest [29 0 R /XYZ 72 739 null] /Title (https://www.researchgate.net/profile/Leo-Swadling) /Parent 1224 0 R >> endobj 1223 0 obj << /Dest [29 0 R /XYZ 70 742 null] /Title (Span) /Parent 1222 0 R /Next 1224 0 R >> endobj 1224 0 obj << /Count 1 /Dest [29 0 R /XYZ 0 842 null] /First 1225 0 R /Last 1225 0 R /Title (https://www.researchgate.net/profile/Leo-Swadling) /Prev 1223 0 R /Parent 1222 0 R /Next 1226 0 R >> endobj 1228 0 obj << /Dest [29 0 R /XYZ 72 724 null] /Title (https://www.linkedin.com/in/leo-swadling-7746b349/) /Parent 1227 0 R >> endobj 1226 0 obj << /Dest [29 0 R /XYZ 70 739 null] /Title ( ) /Prev 1224 0 R /Parent 1222 0 R /Next 1227 0 R >> endobj 1227 0 obj << /Count 1 /Dest [29 0 R /XYZ 0 842 null] /First 1228 0 R /Last 1228 0 R /Title (https://www.linkedin.com/in/leo-swadling-7746b349/) /Prev 1226 0 R /Parent 1222 0 R /Next 1229 0 R >> endobj 1229 0 obj << /Dest [29 0 R /XYZ 72 724 null] /Title ( ) /Prev 1227 0 R /Parent 1222 0 R >> endobj 1221 0 obj << /Dest [29 0 R /XYZ 72 754 null] /Title ( ) /Prev 1217 0 R /Parent 343 0 R /Next 1222 0 R >> endobj 1232 0 obj << /Dest [29 0 R /XYZ 72 710 null] /Title (https://twitter.com/Leo1401j) /Parent 1231 0 R >> endobj 1231 0 obj << /Count 1 /Dest [29 0 R /XYZ 0 842 null] /First 1232 0 R /Last 1232 0 R /Title (https://twitter.com/Leo1401j) /Parent 1230 0 R /Next 1233 0 R >> endobj 1233 0 obj << /Dest [29 0 R /XYZ 72 710 null] /Title ( ) /Prev 1231 0 R /Parent 1230 0 R >> endobj 1222 0 obj << /Count 7 /Dest [29 0 R /XYZ 70 742 null] /First 1223 0 R /Last 1229 0 R /Title (P) /Prev 1221 0 R /Parent 343 0 R /Next 1230 0 R >> endobj 1230 0 obj << /Count 3 /Dest [29 0 R /XYZ 0 842 null] /First 1231 0 R /Last 1233 0 R /Title (https://twitter.com/Leo1401j) /Prev 1222 0 R /Parent 343 0 R /Next 1234 0 R >> endobj 1234 0 obj << /Dest [29 0 R /XYZ 72 695 null] /Title ( ) /Prev 1230 0 R /Parent 343 0 R /Next 1235 0 R >> endobj 1235 0 obj << /Dest [29 0 R /XYZ 72 680 null] /Title (Keywords: T cells, viruses, vaccines, tissue-residency, scRNAseq, TCR, HCV, HBV, SARS-CoV-2 ) /Prev 1234 0 R /Parent 343 0 R /Next 1236 0 R >> endobj 1236 0 obj << /Dest [29 0 R /XYZ 72 651 null] /Title ( ) /Prev 1235 0 R /Parent 343 0 R /Next 1237 0 R >> endobj 1237 0 obj << /Dest [29 0 R /XYZ 72 637 null] /Title (Overall, my research aims to establish T-cell correlates of protection by integrating high-resolution single-cell studies of T-cell quality \(function, phenotype, trafficking\) and specificity \(virus, protein, epitope, TCR clonality\) at the extremes of controlled or uncontrolled viral infections, and to design vaccines to recapitulate and test these correlates. ) /Prev 1236 0 R /Parent 343 0 R /Next 1238 0 R >> endobj 1238 0 obj << /Dest [29 0 R /XYZ 72 580 null] /Title ( ) /Prev 1237 0 R /Parent 343 0 R /Next 1239 0 R >> endobj 1239 0 obj << /Dest [29 0 R /XYZ 72 566 null] /Title (Anti-viral immunity and vaccine development ) /Prev 1238 0 R /Parent 343 0 R /Next 1240 0 R >> endobj 1240 0 obj << /Dest [29 0 R /XYZ 72 552 null] /Title ( ) /Prev 1239 0 R /Parent 343 0 R /Next 1241 0 R >> endobj 1241 0 obj << /Dest [29 0 R /XYZ 72 538 null] /Title (Defining high-resolution T cell correlates of protection in abortive versus seropositive SARS-CoV-2 Infection ) /Prev 1240 0 R /Parent 343 0 R /Next 1242 0 R >> endobj 1242 0 obj << /Dest [29 0 R /XYZ 72 513 null] /Title (We identified an association between T cells targeting the essential highly conserved replication-transcription complex \(e.g., polymerase and helicase\) and early control of SARS-CoV-2 without seroconversion or disease \(Abortive infection; Swadling et al Nature 2022\), we are now characterising this population of T cells using unbiased and targeted approaches to identify qualities and specificities that best correlate with protection. With Prof. Mala Maini and Prof. Ellie Barnes \(Uni of Oxford\) we are testing) /Prev 1241 0 R /Parent 343 0 R /Next 1243 0 R >> endobj 1243 0 obj << /Dest [29 0 R /XYZ 108 426 null] /Title ( ) /Prev 1242 0 R /Parent 343 0 R /Next 1244 0 R >> endobj 1244 0 obj << /Dest [29 0 R /XYZ 72 414 null] /Title (Rational Design of cross-protective T cell vaccines ) /Prev 1243 0 R /Parent 343 0 R /Next 1245 0 R >> endobj 1245 0 obj << /Dest [29 0 R /XYZ 72 400 null] /Title (We are particularly interested in understanding the fundamental rules that underpin T cell cross-reactivity and how vaccines can be rationally designed to induce the most cross-protective immunity. We are studying viral sequence evolution and positive selection at T cell epitopes \(Lucy van Dorp, UCL Genetics\) and TCR characteristics \(Dr Andreas Mayer, ULC\) at cross-reactive epitopes to allow prioritisation of epitopes for inclusion in T cell vaccines. ) /Prev 1244 0 R /Parent 343 0 R /Next 1246 0 R >> endobj 1246 0 obj << /Dest [29 0 R /XYZ 108 328 null] /Title ( ) /Prev 1245 0 R /Parent 343 0 R /Next 1247 0 R >> endobj 1247 0 obj << /Dest [29 0 R /XYZ 72 314 null] /Title (Bioinformatic Delineation of the TCR signature of HBV control ) /Prev 1246 0 R /Parent 343 0 R /Next 1248 0 R >> endobj 1248 0 obj << /Dest [29 0 R /XYZ 72 300 null] /Title (We are identifying protective TCR sequences from the site of infection, the liver, for use in next generation TCR gene therapy for hepatitis-B virus and to probe the biological link between specificity and function. We are also investigating T cell adaptation to the liver environment \(Swadling et al Cell Rep 2020, Stamataki/Swading Immunology 2018\). ) /Prev 1247 0 R /Parent 343 0 R /Next 1249 0 R >> endobj 1249 0 obj << /Dest [29 0 R /XYZ 108 243 null] /Title ( ) /Prev 1248 0 R /Parent 343 0 R /Next 1250 0 R >> endobj 1250 0 obj << /Dest [29 0 R /XYZ 72 230 null] /Title (Diniz et al. T cell control of SARS-CoV-2:When, Which and Where? \(2023\) Semin Immunol. doi: 10.1016/j.smim.2023.101828 ) /Prev 1249 0 R /Parent 343 0 R /Next 1251 0 R >> endobj 1251 0 obj << /Dest [29 0 R /XYZ 72 205 null] /Title ( ) /Prev 1250 0 R /Parent 343 0 R /Next 1252 0 R >> endobj 1252 0 obj << /Dest [29 0 R /XYZ 72 193 null] /Title (Swadling et al. Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 \(2022\) Nature. DOI: 10.1038/s41586-021-04186-8 ) /Prev 1251 0 R /Parent 343 0 R /Next 1253 0 R >> endobj 1253 0 obj << /Dest [29 0 R /XYZ 72 169 null] /Title ( ) /Prev 1252 0 R /Parent 343 0 R /Next 1254 0 R >> endobj 1254 0 obj << /Dest [29 0 R /XYZ 72 156 null] /Title (Swadling et al. Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence. \(2020\) Cell Rep. DOI: 10.1016/j.celrep.2019.12.050 ) /Prev 1253 0 R /Parent 343 0 R /Next 1255 0 R >> endobj 1255 0 obj << /Dest [29 0 R /XYZ 72 132 null] /Title ( ) /Prev 1254 0 R /Parent 343 0 R /Next 1256 0 R >> endobj 1256 0 obj << /Dest [29 0 R /XYZ 72 120 null] /Title (Swadling et al. A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory \(2014\) Sci Trans Med DOI: 10.1126/scitranslmed.300918. ) /Prev 1255 0 R /Parent 343 0 R /Next 1257 0 R >> endobj 1257 0 obj << /Dest [29 0 R /XYZ 72 95 null] /Title ( ) /Prev 1256 0 R /Parent 343 0 R /Next 1258 0 R >> endobj 1258 0 obj << /Dest [30 0 R /XYZ 72 783 null] /Title (Dr Yasu Takeuchi ) /Prev 1257 0 R /Parent 343 0 R /Next 1259 0 R >> endobj 1262 0 obj << /Dest [30 0 R /XYZ 72 768 null] /Title (y.takeuchi@ucl.ac.uk) /Parent 1261 0 R >> endobj 1261 0 obj << /Count 1 /Dest [30 0 R /XYZ 0 842 null] /First 1262 0 R /Last 1262 0 R /Title (y.takeuchi@ucl.ac.uk) /Parent 1260 0 R /Next 1263 0 R >> endobj 1263 0 obj << /Dest [30 0 R /XYZ 72 768 null] /Title ( ) /Prev 1261 0 R /Parent 1260 0 R >> endobj 1259 0 obj << /Dest [30 0 R /XYZ 421 785 null] /Title (Figure) /Prev 1258 0 R /Parent 343 0 R /Next 1260 0 R >> endobj 1260 0 obj << /Count 3 /Dest [30 0 R /XYZ 0 842 null] /First 1261 0 R /Last 1263 0 R /Title (y.takeuchi@ucl.ac.uk) /Prev 1259 0 R /Parent 343 0 R /Next 1264 0 R >> endobj 1267 0 obj << /Dest [30 0 R /XYZ 72 740 null] /Title (/infection-immunity/people/dr-yasuhiro-takeuchi) /Parent 1266 0 R >> endobj 1266 0 obj << /Count 1 /Dest [30 0 R /XYZ 0 842 null] /First 1267 0 R /Last 1267 0 R /Title (/infection-immunity/people/dr-yasuhiro-takeuchi) /Parent 1265 0 R /Next 1268 0 R >> endobj 1268 0 obj << /Dest [30 0 R /XYZ 72 740 null] /Title ( ) /Prev 1266 0 R /Parent 1265 0 R >> endobj 1264 0 obj << /Dest [30 0 R /XYZ 72 754 null] /Title ( ) /Prev 1260 0 R /Parent 343 0 R /Next 1265 0 R >> endobj 1265 0 obj << /Count 3 /Dest [30 0 R /XYZ 0 842 null] /First 1266 0 R /Last 1268 0 R /Title (/infection-immunity/people/dr-yasuhiro-takeuchi) /Prev 1264 0 R /Parent 343 0 R /Next 1269 0 R >> endobj 1269 0 obj << /Dest [30 0 R /XYZ 72 726 null] /Title ( ) /Prev 1265 0 R /Parent 343 0 R /Next 1270 0 R >> endobj 1270 0 obj << /Dest [30 0 R /XYZ 72 712 null] /Title (Emerging Virus Preparedness: Use of Gene Therapy Vectors The current COVID-19 pandemic highlights importance of preparedness against emerging infectious diseases. While it is difficult to predict what pathogens will cause future pandemics, influenza viruses remain major suspects with high potential to cause pandemics. Furthermore, there are several regionally emerging viruses prioritised in the World Health Organisation \(WHO\) R&D Blueprint [1], including viruses like Zika virus \(ZIKV\) which in 2016 was decl) /Prev 1269 0 R /Parent 343 0 R /Next 1271 0 R >> endobj 1271 0 obj << /Dest [30 0 R /XYZ 72 544 null] /Title ( ) /Prev 1270 0 R /Parent 343 0 R /Next 1272 0 R >> endobj 1272 0 obj << /Dest [30 0 R /XYZ 72 530 null] /Title (Universal immunoprophylaxis against influenza viruses by gene-delivered nanobodies \(in collaboration with Dr Simon Hufton, Biotherapeutics and Advanced Therapies, MHRA\): We have been developing alpaca-derived, cross-subtype neutralizing single domain antibodies \(nanobodies\) against influenza and their delivery using gene therapy vectors [2]. This gene-mediated immunoprophylaxis approach may allow us to protect the high-risk population with poor vaccine response \(e.g. immunocompromised patients, elderly etc\)) /Prev 1271 0 R /Parent 343 0 R /Next 1273 0 R >> endobj 1273 0 obj << /Dest [30 0 R /XYZ 72 375 null] /Title ( ) /Prev 1272 0 R /Parent 343 0 R /Next 1274 0 R >> endobj 1274 0 obj << /Dest [30 0 R /XYZ 72 361 null] /Title (Development of pseudotypes of viruses with global epidemic potential \(in collaboration with Dr Giada Mattiuzzo, Vaccines, MHRA\): The Emerging Virus Group at NIBSC has been contributing to a rapid response to emergencies caused by enveloped viruses by developing standards and assays for diagnostics and serology. These activities heavily rely on pseudotype virus \(PV\) technology based on gene therapy vector systems [3] which enables us to study dangerous viruses more safely and outside special containment like) /Prev 1273 0 R /Parent 343 0 R /Next 1275 0 R >> endobj 1279 0 obj << /Dest [30 0 R /XYZ 72 193 null] /Title (https://www.who.int/activities/prioritizing-diseases-for-research-and-development-inemergency-contexts) /Parent 1278 0 R >> endobj 1277 0 obj << /Dest [30 0 R /XYZ 72 193 null] /Title ([1] ) /Parent 1276 0 R /Next 1278 0 R >> endobj 1278 0 obj << /Count 1 /Dest [30 0 R /XYZ 0 842 null] /First 1279 0 R /Last 1279 0 R /Title (https://www.who.int/activities/prioritizing-diseases-for-research-and-development-inemergency-contexts) /Prev 1277 0 R /Parent 1276 0 R /Next 1280 0 R >> endobj 1280 0 obj << /Dest [30 0 R /XYZ 72 179 null] /Title ( ) /Prev 1278 0 R /Parent 1276 0 R >> endobj 1275 0 obj << /Dest [30 0 R /XYZ 72 207 null] /Title ( ) /Prev 1274 0 R /Parent 343 0 R /Next 1276 0 R >> endobj 1284 0 obj << /Dest [30 0 R /XYZ 88 165 null] /Title (https://www.frontiersin.org/articles/10.3389/fimmu.2020.00627/full) /Parent 1283 0 R >> endobj 1282 0 obj << /Dest [30 0 R /XYZ 72 165 null] /Title ([2] ) /Parent 1281 0 R /Next 1283 0 R >> endobj 1283 0 obj << /Count 1 /Dest [30 0 R /XYZ 0 842 null] /First 1284 0 R /Last 1284 0 R /Title (https://www.frontiersin.org/articles/10.3389/fimmu.2020.00627/full) /Prev 1282 0 R /Parent 1281 0 R /Next 1285 0 R >> endobj 1285 0 obj << /Dest [30 0 R /XYZ 87 165 null] /Title ( ) /Prev 1283 0 R /Parent 1281 0 R >> endobj 1276 0 obj << /Count 4 /Dest [30 0 R /XYZ 72 193 null] /First 1277 0 R /Last 1280 0 R /Title ([1] ) /Prev 1275 0 R /Parent 343 0 R /Next 1281 0 R >> endobj 1289 0 obj << /Dest [30 0 R /XYZ 88 151 null] /Title (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118154/?report=classic) /Parent 1288 0 R >> endobj 1287 0 obj << /Dest [30 0 R /XYZ 72 151 null] /Title ([3] ) /Parent 1286 0 R /Next 1288 0 R >> endobj 1288 0 obj << /Count 1 /Dest [30 0 R /XYZ 0 842 null] /First 1289 0 R /Last 1289 0 R /Title (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118154/?report=classic) /Prev 1287 0 R /Parent 1286 0 R /Next 1290 0 R >> endobj 1290 0 obj << /Dest [30 0 R /XYZ 87 151 null] /Title ( ) /Prev 1288 0 R /Parent 1286 0 R >> endobj 1281 0 obj << /Count 4 /Dest [30 0 R /XYZ 72 165 null] /First 1282 0 R /Last 1285 0 R /Title ([2] ) /Prev 1276 0 R /Parent 343 0 R /Next 1286 0 R >> endobj 1294 0 obj << /Dest [30 0 R /XYZ 88 137 null] /Title (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759245/) /Parent 1293 0 R >> endobj 1292 0 obj << /Dest [30 0 R /XYZ 72 137 null] /Title ([4] ) /Parent 1291 0 R /Next 1293 0 R >> endobj 1293 0 obj << /Count 1 /Dest [30 0 R /XYZ 0 842 null] /First 1294 0 R /Last 1294 0 R /Title (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759245/) /Prev 1292 0 R /Parent 1291 0 R /Next 1295 0 R >> endobj 1295 0 obj << /Dest [30 0 R /XYZ 87 137 null] /Title ( ) /Prev 1293 0 R /Parent 1291 0 R >> endobj 1286 0 obj << /Count 4 /Dest [30 0 R /XYZ 72 151 null] /First 1287 0 R /Last 1290 0 R /Title ([3] ) /Prev 1281 0 R /Parent 343 0 R /Next 1291 0 R >> endobj 1291 0 obj << /Count 4 /Dest [30 0 R /XYZ 72 137 null] /First 1292 0 R /Last 1295 0 R /Title ([4] ) /Prev 1286 0 R /Parent 343 0 R /Next 1296 0 R >> endobj 1296 0 obj << /Dest [30 0 R /XYZ 72 122 null] /Title ( ) /Prev 1291 0 R /Parent 343 0 R /Next 1297 0 R >> endobj 1297 0 obj << /Dest [30 0 R /XYZ 72 109 null] /Title ( ) /Prev 1296 0 R /Parent 343 0 R /Next 1298 0 R >> endobj 1298 0 obj << /Dest [30 0 R /XYZ 72 94 null] /Title ( ) /Prev 1297 0 R /Parent 343 0 R /Next 1299 0 R >> endobj 1299 0 obj << /Dest [30 0 R /XYZ 72 79 null] /Title ( ) /Prev 1298 0 R /Parent 343 0 R /Next 1300 0 R >> endobj 1300 0 obj << /Dest [31 0 R /XYZ 72 783 null] /Title (Professor Pavel Tolar ) /Prev 1299 0 R /Parent 343 0 R /Next 1301 0 R >> endobj 1304 0 obj << /Dest [31 0 R /XYZ 72 769 null] /Title (p.tolar@ucl.ac.uk) /Parent 1303 0 R >> endobj 1303 0 obj << /Count 1 /Dest [31 0 R /XYZ 0 842 null] /First 1304 0 R /Last 1304 0 R /Title (p.tolar@ucl.ac.uk) /Parent 1302 0 R /Next 1305 0 R >> endobj 1305 0 obj << /Dest [31 0 R /XYZ 72 769 null] /Title ( ) /Prev 1303 0 R /Parent 1302 0 R >> endobj 1301 0 obj << /Dest [31 0 R /XYZ 410 802 null] /Title (Figure) /Prev 1300 0 R /Parent 343 0 R /Next 1302 0 R >> endobj 1302 0 obj << /Count 3 /Dest [31 0 R /XYZ 0 842 null] /First 1303 0 R /Last 1305 0 R /Title (p.tolar@ucl.ac.uk) /Prev 1301 0 R /Parent 343 0 R /Next 1306 0 R >> endobj 1309 0 obj << /Dest [31 0 R /XYZ 72 741 null] /Title (/infection-immunity/people/dr-pavel-tolar) /Parent 1308 0 R >> endobj 1308 0 obj << /Count 1 /Dest [31 0 R /XYZ 0 842 null] /First 1309 0 R /Last 1309 0 R /Title (/infection-immunity/people/dr-pavel-tolar) /Parent 1307 0 R /Next 1310 0 R >> endobj 1310 0 obj << /Dest [31 0 R /XYZ 72 741 null] /Title ( ) /Prev 1308 0 R /Parent 1307 0 R >> endobj 1306 0 obj << /Dest [31 0 R /XYZ 72 755 null] /Title ( ) /Prev 1302 0 R /Parent 343 0 R /Next 1307 0 R >> endobj 1307 0 obj << /Count 3 /Dest [31 0 R /XYZ 0 842 null] /First 1308 0 R /Last 1310 0 R /Title (/infection-immunity/people/dr-pavel-tolar) /Prev 1306 0 R /Parent 343 0 R /Next 1311 0 R >> endobj 1311 0 obj << /Dest [31 0 R /XYZ 72 726 null] /Title ( ) /Prev 1307 0 R /Parent 343 0 R /Next 1312 0 R >> endobj 1312 0 obj << /Dest [31 0 R /XYZ 72 712 null] /Title ( ) /Prev 1311 0 R /Parent 343 0 R /Next 1313 0 R >> endobj 1313 0 obj << /Dest [31 0 R /XYZ 72 692 null] /Title (B cell signalling and antigen presentation in immune protection and pathology ) /Prev 1312 0 R /Parent 343 0 R /Next 1314 0 R >> endobj 1314 0 obj << /Dest [31 0 R /XYZ 72 672 null] /Title (We are interested in the fundamental mechanisms by which B lymphocytes detect and respond to invading pathogens. We have pioneered the idea that the B cell antigen receptor \(BCR\) uses mechano-sensitivity to discriminate the binding to antigens. We would like to understand the molecular pathways by which the BCR regulates B cell activation and antigen presentation and how these pathways promote the selection of protective B cell clones during antibody responses. Conversely, we are investigating why the BCR s) /Prev 1313 0 R /Parent 343 0 R /Next 1315 0 R >> endobj 1318 0 obj << /Dest [31 0 R /XYZ 90 506 null] /Title (1. Regulation of B cell germinal centre reactions by antigen retention on follicular dendritic cells ) /Parent 1317 0 R >> endobj 1320 0 obj << /Dest [31 0 R /XYZ 90 472 null] /Title (2. Identification of novel mechanisms controlling IgE B cell responses in allergy ) /Parent 1319 0 R >> endobj 1317 0 obj << /Count 1 /Dest [31 0 R /XYZ 90 506 null] /First 1318 0 R /Last 1318 0 R /Title (1. Regulation of B cell germinal centre reactions by antigen retention on follicular dendritic cells ) /Parent 1316 0 R /Next 1319 0 R >> endobj 1322 0 obj << /Dest [31 0 R /XYZ 90 452 null] /Title (3. Mapping of pathways promoting the pathogenesis and transformation of B cell lymphomas ) /Parent 1321 0 R >> endobj 1319 0 obj << /Count 1 /Dest [31 0 R /XYZ 90 472 null] /First 1320 0 R /Last 1320 0 R /Title (2. Identification of novel mechanisms controlling IgE B cell responses in allergy ) /Prev 1317 0 R /Parent 1316 0 R /Next 1321 0 R >> endobj 1321 0 obj << /Count 1 /Dest [31 0 R /XYZ 90 452 null] /First 1322 0 R /Last 1322 0 R /Title (3. Mapping of pathways promoting the pathogenesis and transformation of B cell lymphomas ) /Prev 1319 0 R /Parent 1316 0 R >> endobj 1315 0 obj << /Dest [31 0 R /XYZ 72 568 null] /Title (We are using a variety of disciplines including immunology, genetics, biophysics, bioinformatics and live-cell imaging to answer these questions. We have had fantastically creative PhD students in the past who have gone on to very successful research careers. Examples of possible PhD projects areas in the lab include: ) /Prev 1314 0 R /Parent 343 0 R /Next 1316 0 R >> endobj 1316 0 obj << /Count 6 /Dest [31 0 R /XYZ 90 506 null] /First 1317 0 R /Last 1321 0 R /Title (1. Regulation of B cell germinal centre reactions by antigen retention on follicular dendritic cells ) /Prev 1315 0 R /Parent 343 0 R /Next 1323 0 R >> endobj 1323 0 obj << /Dest [31 0 R /XYZ 72 418 null] /Title ( ) /Prev 1316 0 R /Parent 343 0 R /Next 1324 0 R >> endobj 1324 0 obj << /Dest [31 0 R /XYZ 72 397 null] /Title (Selected publications: ) /Prev 1323 0 R /Parent 343 0 R /Next 1325 0 R >> endobj 1325 0 obj << /Dest [31 0 R /XYZ 72 377 null] /Title (Mart\355nez-Ria\361o, A., Wang, S., Boeing, S., Minoughan, S., Casal, A., Spillane, K. M., Ludewig, B. & Tolar, P. \(2023\) Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network. Nat. Immunol. 24, 1281\2051294. ) /Prev 1324 0 R /Parent 343 0 R /Next 1326 0 R >> endobj 1326 0 obj << /Dest [31 0 R /XYZ 72 329 null] /Title (Chen, Q., Menon, R. P., Masino, L., Tolar, P.* & Rosenthal, P. B. \(2023\) Structural basis for Fc receptor recognition of immunoglobulin M. Nat. Struct. Mol. Biol. 30, 1033\2051039. ) /Prev 1325 0 R /Parent 343 0 R /Next 1327 0 R >> endobj 1327 0 obj << /Dest [31 0 R /XYZ 72 296 null] /Title (Newman, R. and Tolar, P. \(2021\) Chronic calcium signaling in IgE+ B cells limits plasma cell differentiation and survival. Immunity 54, 2756-2771.e10. ) /Prev 1326 0 R /Parent 343 0 R /Next 1328 0 R >> endobj 1328 0 obj << /Dest [31 0 R /XYZ 72 261 null] /Title (Spillane, K. M., Tolar, P. \(2017\) B cell antigen extraction is regulated by the physical properties of antigen presenting cells. J. Cell Biol. 216, 217\205230. ) /Prev 1327 0 R /Parent 343 0 R /Next 1329 0 R >> endobj 1329 0 obj << /Dest [31 0 R /XYZ 72 227 null] /Title (Nowosad, C. R., Spillane, K. M., and Tolar, P. \(2016\) Germinal center B cells recognize antigen through a specialized immune synapse architecture. Nat Immunol 17, 870-77. ) /Prev 1328 0 R /Parent 343 0 R /Next 1330 0 R >> endobj 1330 0 obj << /Dest [31 0 R /XYZ 72 193 null] /Title (Natkanski, E., Lee, W.-Y., Mistry, B., Casal, A., Molloy, J.E., and Tolar, P. \(2013\) B cells use mechanical energy to discriminate antigen affinities. Science 340, 1587\2051590. ) /Prev 1329 0 R /Parent 343 0 R /Next 1331 0 R >> endobj 1331 0 obj << /Dest [31 0 R /XYZ 72 159 null] /Title ( ) /Prev 1330 0 R /Parent 343 0 R /Next 1332 0 R >> endobj 1332 0 obj << /Dest [31 0 R /XYZ 72 132 null] /Title ( ) /Prev 1331 0 R /Parent 343 0 R /Next 1333 0 R >> endobj 1333 0 obj << /Dest [31 0 R /XYZ 72 106 null] /Title ( ) /Prev 1332 0 R /Parent 343 0 R /Next 1334 0 R >> endobj 1334 0 obj << /Dest [31 0 R /XYZ 72 79 null] /Title ( ) /Prev 1333 0 R /Parent 343 0 R /Next 1335 0 R >> endobj 1335 0 obj << /Dest [32 0 R /XYZ 72 783 null] /Title (Prof Greg Towers ) /Prev 1334 0 R /Parent 343 0 R /Next 1336 0 R >> endobj 1339 0 obj << /Dest [32 0 R /XYZ 72 756 null] /Title (g.towers@ucl.ac.uk) /Parent 1338 0 R >> endobj 1338 0 obj << /Count 1 /Dest [32 0 R /XYZ 0 842 null] /First 1339 0 R /Last 1339 0 R /Title (g.towers@ucl.ac.uk) /Parent 1337 0 R /Next 1340 0 R >> endobj 1340 0 obj << /Dest [32 0 R /XYZ 72 756 null] /Title ( ) /Prev 1338 0 R /Parent 1337 0 R >> endobj 1336 0 obj << /Dest [32 0 R /XYZ 363 785 null] /Title (Figure) /Prev 1335 0 R /Parent 343 0 R /Next 1337 0 R >> endobj 1343 0 obj << /Dest [32 0 R /XYZ 72 730 null] /Title (/infection-immunity/people/professor-greg-towers) /Parent 1342 0 R >> endobj 1342 0 obj << /Count 1 /Dest [32 0 R /XYZ 0 842 null] /First 1343 0 R /Last 1343 0 R /Title (/infection-immunity/people/professor-greg-towers) /Parent 1341 0 R /Next 1344 0 R >> endobj 1344 0 obj << /Dest [32 0 R /XYZ 72 715 null] /Title ( ) /Prev 1342 0 R /Parent 1341 0 R >> endobj 1337 0 obj << /Count 3 /Dest [32 0 R /XYZ 0 842 null] /First 1338 0 R /Last 1340 0 R /Title (g.towers@ucl.ac.uk) /Prev 1336 0 R /Parent 343 0 R /Next 1341 0 R >> endobj 1341 0 obj << /Count 3 /Dest [32 0 R /XYZ 0 842 null] /First 1342 0 R /Last 1344 0 R /Title (/infection-immunity/people/professor-greg-towers) /Prev 1337 0 R /Parent 343 0 R /Next 1345 0 R >> endobj 1345 0 obj << /Dest [32 0 R /XYZ 72 689 null] /Title (Host-Virus Interactions and evasion of innate immune sensing by HIV ) /Prev 1341 0 R /Parent 343 0 R /Next 1346 0 R >> endobj 1346 0 obj << /Dest [32 0 R /XYZ 72 662 null] /Title ( ) /Prev 1345 0 R /Parent 343 0 R /Next 1347 0 R >> endobj 1347 0 obj << /Dest [32 0 R /XYZ 72 648 null] /Title (Our lab studies the interaction between viruses and their hosts with a focus on HIV-1. We investigate the molecular details of host-virus interactions to help us understand mammalian cell biology, virology and evolution and to develop novel therapeutic approaches for viral infection and inflammation. Research is focused on how viruses evade the intracellular innate immune system that typically protects us from infection. We have shown that HIV-1 uses host-derived cofactors such as cyclophilin A and CPSF6 to) /Prev 1346 0 R /Parent 343 0 R /Next 1348 0 R >> endobj 1348 0 obj << /Dest [32 0 R /XYZ 72 438 null] /Title ( ) /Prev 1347 0 R /Parent 343 0 R /Next 1349 0 R >> endobj 1349 0 obj << /Dest [32 0 R /XYZ 72 424 null] /Title (We are funded by a Wellcome Trust Senior Fellowship, a European Research Council Advanced Grant, the Medical Research Council and the NIHR UCL/UCLH Biomedical Research Centre. We employ 8 post-doctoral scientists, including an industry trained chemist, 2 PhD students and a clinical PhD fellow. ) /Prev 1348 0 R /Parent 343 0 R /Next 1350 0 R >> endobj 1350 0 obj << /Dest [32 0 R /XYZ 72 367 null] /Title ( ) /Prev 1349 0 R /Parent 343 0 R /Next 1351 0 R >> endobj 1351 0 obj << /Dest [32 0 R /XYZ 72 354 null] /Title (Current questions include ) /Prev 1350 0 R /Parent 343 0 R /Next 1352 0 R >> endobj 1352 0 obj << /Dest [32 0 R /XYZ 72 340 null] /Title (1. What is the nature of the innate immune response that is unleashed when HIV is revealed to innate sensors? ) /Prev 1351 0 R /Parent 343 0 R /Next 1353 0 R >> endobj 1353 0 obj << /Dest [32 0 R /XYZ 72 312 null] /Title (2. How does cytoplasmic DNA sensing work and how do viruses evade or antagonize it? ) /Prev 1352 0 R /Parent 343 0 R /Next 1354 0 R >> endobj 1354 0 obj << /Dest [32 0 R /XYZ 72 298 null] /Title (3. Can we develop novel, broad specificity, antiviral inhibitors that trigger an innate immune response to protect against, or treat, viral infection? ) /Prev 1353 0 R /Parent 343 0 R /Next 1355 0 R >> endobj 1359 0 obj << /Dest [32 0 R /XYZ 272 256 null] /Title (www.ucl.ac.uk/towers-lab) /Parent 1358 0 R >> endobj 1357 0 obj << /Dest [32 0 R /XYZ 72 256 null] /Title (See website for further details of projects: ) /Parent 1356 0 R /Next 1358 0 R >> endobj 1358 0 obj << /Count 1 /Dest [32 0 R /XYZ 0 842 null] /First 1359 0 R /Last 1359 0 R /Title (www.ucl.ac.uk/towers-lab) /Prev 1357 0 R /Parent 1356 0 R /Next 1360 0 R >> endobj 1360 0 obj << /Dest [32 0 R /XYZ 272 256 null] /Title ( ) /Prev 1358 0 R /Parent 1356 0 R >> endobj 1355 0 obj << /Dest [32 0 R /XYZ 72 270 null] /Title ( ) /Prev 1354 0 R /Parent 343 0 R /Next 1356 0 R >> endobj 1356 0 obj << /Count 4 /Dest [32 0 R /XYZ 72 256 null] /First 1357 0 R /Last 1360 0 R /Title (See website for further details of projects: ) /Prev 1355 0 R /Parent 343 0 R /Next 1361 0 R >> endobj 1361 0 obj << /Dest [32 0 R /XYZ 72 242 null] /Title ( ) /Prev 1356 0 R /Parent 343 0 R /Next 1362 0 R >> endobj 1365 0 obj << /Dest [32 0 R /XYZ 90 213 null] /Title (\200 Fletcher, A. J., D. E. Christensen, C. Nelson, C. P. Tan, T. Schaller, P. J. Lehner, W. I. Sundquist, and G. J. Towers. 2015. TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription. EMBO J 34:2078-2095. ) /Parent 1364 0 R >> endobj 1367 0 obj << /Dest [32 0 R /XYZ 90 170 null] /Title (\200 Rasaiyaah, J., C. P. Tan, A. J. Fletcher, A. J. Price, C. Blondeau, L. Hilditch, D. A. Jacques, D. L. Selwood, L. C. James, M. Noursadeghi and G. J. Towers. 2013. HIV-1 evades innate immune recognition through specific co-factor recruitment. Nature. 503:402-405. ) /Parent 1366 0 R >> endobj 1364 0 obj << /Count 1 /Dest [32 0 R /XYZ 90 213 null] /First 1365 0 R /Last 1365 0 R /Title (\200 Fletcher, A. J., D. E. Christensen, C. Nelson, C. P. Tan, T. Schaller, P. J. Lehner, W. I. Sundquist, and G. J. Towers. 2015. TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription. EMBO J 34:2078-2095. ) /Parent 1363 0 R /Next 1366 0 R >> endobj 1369 0 obj << /Dest [32 0 R /XYZ 90 127 null] /Title (\200 Price, A. J., A. J. Fletcher, T. Schaller, T. Elliot, K. Lee, V. N. Kewalramani, J. Chin, G. J. Towers, and L. C. James. 2012. CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. PLoS Pathogens 8:e1002896. ) /Parent 1368 0 R >> endobj 1366 0 obj << /Count 1 /Dest [32 0 R /XYZ 90 170 null] /First 1367 0 R /Last 1367 0 R /Title (\200 Rasaiyaah, J., C. P. Tan, A. J. Fletcher, A. J. Price, C. Blondeau, L. Hilditch, D. A. Jacques, D. L. Selwood, L. C. James, M. Noursadeghi and G. J. Towers. 2013. HIV-1 evades innate immune recognition through specific co-factor recruitment. Nature. 503:402-405. ) /Prev 1364 0 R /Parent 1363 0 R /Next 1368 0 R >> endobj 1368 0 obj << /Count 1 /Dest [32 0 R /XYZ 90 127 null] /First 1369 0 R /Last 1369 0 R /Title (\200 Price, A. J., A. J. Fletcher, T. Schaller, T. Elliot, K. Lee, V. N. Kewalramani, J. Chin, G. J. Towers, and L. C. James. 2012. CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. PLoS Pathogens 8:e1002896. ) /Prev 1366 0 R /Parent 1363 0 R >> endobj 1362 0 obj << /Dest [32 0 R /XYZ 72 228 null] /Title (Recent Publications ) /Prev 1361 0 R /Parent 343 0 R /Next 1363 0 R >> endobj 1363 0 obj << /Count 6 /Dest [32 0 R /XYZ 90 213 null] /First 1364 0 R /Last 1368 0 R /Title (\200 Fletcher, A. J., D. E. Christensen, C. Nelson, C. P. Tan, T. Schaller, P. J. Lehner, W. I. Sundquist, and G. J. Towers. 2015. TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription. EMBO J 34:2078-2095. ) /Prev 1362 0 R /Parent 343 0 R /Next 1370 0 R >> endobj 1370 0 obj << /Dest [32 0 R /XYZ 72 85 null] /Title ( ) /Prev 1363 0 R /Parent 343 0 R /Next 1371 0 R >> endobj 1371 0 obj << /Dest [33 0 R /XYZ 72 783 null] /Title (Prof Lucy Walker ) /Prev 1370 0 R /Parent 343 0 R /Next 1372 0 R >> endobj 1375 0 obj << /Dest [33 0 R /XYZ 72 768 null] /Title (lucy.walker@ucl.ac.uk) /Parent 1374 0 R >> endobj 1374 0 obj << /Count 1 /Dest [33 0 R /XYZ 0 842 null] /First 1375 0 R /Last 1375 0 R /Title (lucy.walker@ucl.ac.uk) /Parent 1373 0 R /Next 1376 0 R >> endobj 1376 0 obj << /Dest [33 0 R /XYZ 72 768 null] /Title ( ) /Prev 1374 0 R /Parent 1373 0 R >> endobj 1372 0 obj << /Dest [33 0 R /XYZ 433 785 null] /Title (Figure) /Prev 1371 0 R /Parent 343 0 R /Next 1373 0 R >> endobj 1373 0 obj << /Count 3 /Dest [33 0 R /XYZ 0 842 null] /First 1374 0 R /Last 1376 0 R /Title (lucy.walker@ucl.ac.uk) /Prev 1372 0 R /Parent 343 0 R /Next 1377 0 R >> endobj 1380 0 obj << /Dest [33 0 R /XYZ 72 739 null] /Title (/infection-immunity/people/professor-lucy-walker) /Parent 1379 0 R >> endobj 1379 0 obj << /Count 1 /Dest [33 0 R /XYZ 0 842 null] /First 1380 0 R /Last 1380 0 R /Title (/infection-immunity/people/professor-lucy-walker) /Parent 1378 0 R /Next 1381 0 R >> endobj 1381 0 obj << /Dest [33 0 R /XYZ 72 724 null] /Title ( ) /Prev 1379 0 R /Parent 1378 0 R >> endobj 1377 0 obj << /Dest [33 0 R /XYZ 72 754 null] /Title ( ) /Prev 1373 0 R /Parent 343 0 R /Next 1378 0 R >> endobj 1378 0 obj << /Count 3 /Dest [33 0 R /XYZ 0 842 null] /First 1379 0 R /Last 1381 0 R /Title (/infection-immunity/people/professor-lucy-walker) /Prev 1377 0 R /Parent 343 0 R /Next 1382 0 R >> endobj 1382 0 obj << /Dest [33 0 R /XYZ 72 710 null] /Title ( ) /Prev 1378 0 R /Parent 343 0 R /Next 1383 0 R >> endobj 1383 0 obj << /Dest [33 0 R /XYZ 72 695 null] /Title (Immune Regulation and Type 1 Diabetes ) /Prev 1382 0 R /Parent 343 0 R /Next 1384 0 R >> endobj 1384 0 obj << /Dest [33 0 R /XYZ 72 680 null] /Title ( ) /Prev 1383 0 R /Parent 343 0 R /Next 1385 0 R >> endobj 1385 0 obj << /Dest [33 0 R /XYZ 72 666 null] /Title ( ) /Prev 1384 0 R /Parent 343 0 R /Next 1386 0 R >> endobj 1386 0 obj << /Dest [33 0 R /XYZ 72 651 null] /Title (The Walker lab is interested in understanding how the immune system is regulated such that responses to infectious agents can be mounted yet tolerance to self-tissues is maintained. Failure of such regulation can lead to the development of autoimmune diseases like Type 1 Diabetes, Rheumatoid Arthritis and Multiple Sclerosis. ) /Prev 1385 0 R /Parent 343 0 R /Next 1387 0 R >> endobj 1387 0 obj << /Dest [33 0 R /XYZ 72 595 null] /Title ( ) /Prev 1386 0 R /Parent 343 0 R /Next 1388 0 R >> endobj 1388 0 obj << /Dest [33 0 R /XYZ 72 581 null] /Title (The group typically comprises around 6-7 researchers, with a broad mix of postdocs, students and technical support. There are currently 2 postdocs, 4 PhD students and 1 research assistant. We hold fortnightly lab meetings and there are also opportunities to present data in larger forums through regular joint lab meetings with other groups within the Institute of Immunity & Transplantation. ) /Prev 1387 0 R /Parent 343 0 R /Next 1389 0 R >> endobj 1389 0 obj << /Dest [33 0 R /XYZ 72 511 null] /Title ( ) /Prev 1388 0 R /Parent 343 0 R /Next 1390 0 R >> endobj 1393 0 obj << /Dest [33 0 R /XYZ 90 482 null] /Title (\200 Pathogenesis and regulation of autoimmune diabetes in animal models and Type 1 Diabetes patients ) /Parent 1392 0 R >> endobj 1395 0 obj << /Dest [33 0 R /XYZ 90 453 null] /Title (\200 Regulatory T cell homeostasis and function in vivo ) /Parent 1394 0 R >> endobj 1392 0 obj << /Count 1 /Dest [33 0 R /XYZ 90 482 null] /First 1393 0 R /Last 1393 0 R /Title (\200 Pathogenesis and regulation of autoimmune diabetes in animal models and Type 1 Diabetes patients ) /Parent 1391 0 R /Next 1394 0 R >> endobj 1397 0 obj << /Dest [33 0 R /XYZ 90 439 null] /Title (\200 The role of costimulatory molecules \(CD28, CTLA-4\) in immune activation and immune regulation ) /Parent 1396 0 R >> endobj 1394 0 obj << /Count 1 /Dest [33 0 R /XYZ 90 453 null] /First 1395 0 R /Last 1395 0 R /Title (\200 Regulatory T cell homeostasis and function in vivo ) /Prev 1392 0 R /Parent 1391 0 R /Next 1396 0 R >> endobj 1399 0 obj << /Dest [33 0 R /XYZ 90 410 null] /Title (\200 The development and function of follicular helper T cells ) /Parent 1398 0 R >> endobj 1396 0 obj << /Count 1 /Dest [33 0 R /XYZ 90 439 null] /First 1397 0 R /Last 1397 0 R /Title (\200 The role of costimulatory molecules \(CD28, CTLA-4\) in immune activation and immune regulation ) /Prev 1394 0 R /Parent 1391 0 R /Next 1398 0 R >> endobj 1398 0 obj << /Count 1 /Dest [33 0 R /XYZ 90 410 null] /First 1399 0 R /Last 1399 0 R /Title (\200 The development and function of follicular helper T cells ) /Prev 1396 0 R /Parent 1391 0 R >> endobj 1390 0 obj << /Dest [33 0 R /XYZ 72 497 null] /Title (The broad areas of interest in the lab are: ) /Prev 1389 0 R /Parent 343 0 R /Next 1391 0 R >> endobj 1391 0 obj << /Count 8 /Dest [33 0 R /XYZ 90 482 null] /First 1392 0 R /Last 1398 0 R /Title (\200 Pathogenesis and regulation of autoimmune diabetes in animal models and Type 1 Diabetes patients ) /Prev 1390 0 R /Parent 343 0 R /Next 1400 0 R >> endobj 1400 0 obj << /Dest [33 0 R /XYZ 72 396 null] /Title ( ) /Prev 1391 0 R /Parent 343 0 R /Next 1401 0 R >> endobj 1401 0 obj << /Dest [33 0 R /XYZ 72 382 null] /Title (The lab is funded by an MRC Programme Grant and additional project grant support from Diabetes UK, the European Union, the Rosetrees Trust and MedImmune. ) /Prev 1400 0 R /Parent 343 0 R /Next 1402 0 R >> endobj 1402 0 obj << /Dest [33 0 R /XYZ 72 354 null] /Title ( ) /Prev 1401 0 R /Parent 343 0 R /Next 1403 0 R >> endobj 1403 0 obj << /Dest [33 0 R /XYZ 72 340 null] /Title (Find out more about the Walker Lab via our website: ) /Prev 1402 0 R /Parent 343 0 R /Next 1404 0 R >> endobj 1407 0 obj << /Dest [33 0 R /XYZ 72 312 null] /Title (http://www.lucywalkerlab.com/index.html) /Parent 1406 0 R >> endobj 1406 0 obj << /Count 1 /Dest [33 0 R /XYZ 0 842 null] /First 1407 0 R /Last 1407 0 R /Title (http://www.lucywalkerlab.com/index.html) /Parent 1405 0 R /Next 1408 0 R >> endobj 1408 0 obj << /Dest [33 0 R /XYZ 72 312 null] /Title ( ) /Prev 1406 0 R /Parent 1405 0 R >> endobj 1404 0 obj << /Dest [33 0 R /XYZ 72 326 null] /Title ( ) /Prev 1403 0 R /Parent 343 0 R /Next 1405 0 R >> endobj 1405 0 obj << /Count 3 /Dest [33 0 R /XYZ 0 842 null] /First 1406 0 R /Last 1408 0 R /Title (http://www.lucywalkerlab.com/index.html) /Prev 1404 0 R /Parent 343 0 R /Next 1409 0 R >> endobj 1409 0 obj << /Dest [33 0 R /XYZ 72 298 null] /Title ( ) /Prev 1405 0 R /Parent 343 0 R /Next 1410 0 R >> endobj 1410 0 obj << /Dest [33 0 R /XYZ 72 283 null] /Title ( ) /Prev 1409 0 R /Parent 343 0 R /Next 1411 0 R >> endobj 1411 0 obj << /Dest [33 0 R /XYZ 72 268 null] /Title ( ) /Prev 1410 0 R /Parent 343 0 R /Next 1412 0 R >> endobj 1412 0 obj << /Dest [33 0 R /XYZ 72 242 null] /Title ( ) /Prev 1411 0 R /Parent 343 0 R /Next 1413 0 R >> endobj 1413 0 obj << /Dest [34 0 R /XYZ 72 783 null] /Title (Dr Alan Xiaodong Zhuang ) /Prev 1412 0 R /Parent 343 0 R /Next 1414 0 R >> endobj 1414 0 obj << /Dest [34 0 R /XYZ 436 779 null] /Title (Figure) /Prev 1413 0 R /Parent 343 0 R /Next 1415 0 R >> endobj 1418 0 obj << /Dest [34 0 R /XYZ 72 755 null] /Title (xiaodong.zhuang@ucl.ac.uk) /Parent 1417 0 R >> endobj 1417 0 obj << /Count 1 /Dest [34 0 R /XYZ 0 842 null] /First 1418 0 R /Last 1418 0 R /Title (xiaodong.zhuang@ucl.ac.uk) /Parent 1416 0 R /Next 1419 0 R >> endobj 1419 0 obj << /Dest [34 0 R /XYZ 72 755 null] /Title ( ) /Prev 1417 0 R /Parent 1416 0 R >> endobj 1415 0 obj << /Dest [34 0 R /XYZ 72 769 null] /Title ( ) /Prev 1414 0 R /Parent 343 0 R /Next 1416 0 R >> endobj 1416 0 obj << /Count 3 /Dest [34 0 R /XYZ 0 842 null] /First 1417 0 R /Last 1419 0 R /Title (xiaodong.zhuang@ucl.ac.uk) /Prev 1415 0 R /Parent 343 0 R /Next 1420 0 R >> endobj 1422 0 obj << /Dest [34 0 R /XYZ 70 731 null] /Title (Span) /Parent 1421 0 R /Next 1423 0 R >> endobj 1423 0 obj << /Dest [34 0 R /XYZ 72 728 null] /Title ( ) /Prev 1422 0 R /Parent 1421 0 R >> endobj 1420 0 obj << /Dest [34 0 R /XYZ 72 742 null] /Title ( ) /Prev 1416 0 R /Parent 343 0 R /Next 1421 0 R >> endobj 1425 0 obj << /Dest [34 0 R /XYZ 70 717 null] /Title (Span) /Parent 1424 0 R /Next 1426 0 R >> endobj 1426 0 obj << /Dest [34 0 R /XYZ 72 715 null] /Title ( ) /Prev 1425 0 R /Parent 1424 0 R >> endobj 1421 0 obj << /Count 2 /Dest [34 0 R /XYZ 70 731 null] /First 1422 0 R /Last 1423 0 R /Title (P) /Prev 1420 0 R /Parent 343 0 R /Next 1424 0 R >> endobj 1428 0 obj << /Dest [34 0 R /XYZ 70 704 null] /Title (Span) /Parent 1427 0 R /Next 1429 0 R >> endobj 1429 0 obj << /Dest [34 0 R /XYZ 72 701 null] /Title (Exploring Circadian Clocks in Viral Infection and Immune Responses) /Prev 1428 0 R /Parent 1427 0 R /Next 1430 0 R >> endobj 1430 0 obj << /Dest [34 0 R /XYZ 380 701 null] /Title ( ) /Prev 1429 0 R /Parent 1427 0 R /Next 1431 0 R >> endobj 1431 0 obj << /Dest [34 0 R /XYZ 382 701 null] /Title ( ) /Prev 1430 0 R /Parent 1427 0 R >> endobj 1424 0 obj << /Count 2 /Dest [34 0 R /XYZ 70 717 null] /First 1425 0 R /Last 1426 0 R /Title (P) /Prev 1421 0 R /Parent 343 0 R /Next 1427 0 R >> endobj 1433 0 obj << /Dest [34 0 R /XYZ 70 690 null] /Title (Span) /Parent 1432 0 R /Next 1434 0 R >> endobj 1434 0 obj << /Dest [34 0 R /XYZ 72 688 null] /Title ( ) /Prev 1433 0 R /Parent 1432 0 R /Next 1435 0 R >> endobj 1435 0 obj << /Dest [34 0 R /XYZ 75 688 null] /Title ( ) /Prev 1434 0 R /Parent 1432 0 R >> endobj 1427 0 obj << /Count 4 /Dest [34 0 R /XYZ 70 704 null] /First 1428 0 R /Last 1431 0 R /Title (P) /Prev 1424 0 R /Parent 343 0 R /Next 1432 0 R >> endobj 1437 0 obj << /Dest [34 0 R /XYZ 70 677 null] /Title (Span) /Parent 1436 0 R /Next 1438 0 R >> endobj 1438 0 obj << /Dest [34 0 R /XYZ 70 675 null] /Title (Our body's internal circadian clock governs various physiological functions, influencing daily biological processes and behavior [1]. Notably, circadian rhythms regulate both innate and adaptive immune responses, impacting susceptibility to viral infections and vaccine effectiveness [2].) /Prev 1437 0 R /Parent 1436 0 R /Next 1439 0 R >> endobj 1439 0 obj << /Dest [34 0 R /XYZ 441 648 null] /Title ( ) /Prev 1438 0 R /Parent 1436 0 R /Next 1440 0 R >> endobj 1440 0 obj << /Dest [34 0 R /XYZ 443 648 null] /Title ( ) /Prev 1439 0 R /Parent 1436 0 R >> endobj 1432 0 obj << /Count 3 /Dest [34 0 R /XYZ 70 690 null] /First 1433 0 R /Last 1435 0 R /Title (P) /Prev 1427 0 R /Parent 343 0 R /Next 1436 0 R >> endobj 1442 0 obj << /Dest [34 0 R /XYZ 70 637 null] /Title (Span) /Parent 1441 0 R /Next 1443 0 R >> endobj 1443 0 obj << /Dest [34 0 R /XYZ 72 634 null] /Title ( ) /Prev 1442 0 R /Parent 1441 0 R /Next 1444 0 R >> endobj 1444 0 obj << /Dest [34 0 R /XYZ 75 634 null] /Title ( ) /Prev 1443 0 R /Parent 1441 0 R >> endobj 1436 0 obj << /Count 4 /Dest [34 0 R /XYZ 70 677 null] /First 1437 0 R /Last 1440 0 R /Title (P) /Prev 1432 0 R /Parent 343 0 R /Next 1441 0 R >> endobj 1446 0 obj << /Dest [34 0 R /XYZ 70 623 null] /Title (Span) /Parent 1445 0 R /Next 1447 0 R >> endobj 1447 0 obj << /Dest [34 0 R /XYZ 70 621 null] /Title (Hepatitis B virus \(HBV\) exclusively targets the human liver, leading to over 270 million chronic infections and 880,000 annual deaths worldwide. Existing antiviral treatments mitigate viral load but lack curative potential, leaving patients at risk of severe liver conditions, including cancer [3]. We recently uncovered a role for the circadian clock in regulating HBV replication and disruption of clock genes within the livers of HBV patients [4], potentially contributing to impaired T-cell functions. Import) /Prev 1446 0 R /Parent 1445 0 R /Next 1448 0 R >> endobj 1448 0 obj << /Dest [34 0 R /XYZ 288 487 null] /Title ( ) /Prev 1447 0 R /Parent 1445 0 R /Next 1449 0 R >> endobj 1449 0 obj << /Dest [34 0 R /XYZ 291 487 null] /Title ( ) /Prev 1448 0 R /Parent 1445 0 R >> endobj 1441 0 obj << /Count 3 /Dest [34 0 R /XYZ 70 637 null] /First 1442 0 R /Last 1444 0 R /Title (P) /Prev 1436 0 R /Parent 343 0 R /Next 1445 0 R >> endobj 1451 0 obj << /Dest [34 0 R /XYZ 70 476 null] /Title (Span) /Parent 1450 0 R /Next 1452 0 R >> endobj 1452 0 obj << /Dest [34 0 R /XYZ 72 473 null] /Title ( ) /Prev 1451 0 R /Parent 1450 0 R /Next 1453 0 R >> endobj 1453 0 obj << /Dest [34 0 R /XYZ 75 473 null] /Title ( ) /Prev 1452 0 R /Parent 1450 0 R >> endobj 1445 0 obj << /Count 4 /Dest [34 0 R /XYZ 70 623 null] /First 1446 0 R /Last 1449 0 R /Title (P) /Prev 1441 0 R /Parent 343 0 R /Next 1450 0 R >> endobj 1455 0 obj << /Dest [34 0 R /XYZ 70 462 null] /Title (Span) /Parent 1454 0 R /Next 1456 0 R >> endobj 1456 0 obj << /Dest [34 0 R /XYZ 70 460 null] /Title (This PhD project offers students hands-on experience in cutting-edge techniques such as multi-color flow cytometry, and immune functional assays. Students will engage in state-of-the-art in vitro and in vivo circadian and infection models and collaborate) /Prev 1455 0 R /Parent 1454 0 R /Next 1457 0 R >> endobj 1457 0 obj << /Dest [34 0 R /XYZ 305 433 null] /Title ( ) /Prev 1456 0 R /Parent 1454 0 R /Next 1458 0 R >> endobj 1458 0 obj << /Dest [34 0 R /XYZ 70 433 null] /Title (closely with our clinical partners to obtain high-quality tissue samples. Additionally, the project will be collaborated with) /Prev 1457 0 R /Parent 1454 0 R /Next 1459 0 R >> endobj 1459 0 obj << /Dest [34 0 R /XYZ 398 419 null] /Title ( ) /Prev 1458 0 R /Parent 1454 0 R /Next 1460 0 R >> endobj 1460 0 obj << /Dest [34 0 R /XYZ 401 419 null] /Title (Prof. Mala Maini,) /Prev 1459 0 R /Parent 1454 0 R /Next 1461 0 R >> endobj 1461 0 obj << /Dest [34 0 R /XYZ 479 419 null] /Title ( ) /Prev 1460 0 R /Parent 1454 0 R /Next 1462 0 R >> endobj 1462 0 obj << /Dest [34 0 R /XYZ 70 419 null] /Title (providing an opportunity to join a highly productive multi-disciplinary team with an outstanding track record.) /Prev 1461 0 R /Parent 1454 0 R /Next 1463 0 R >> endobj 1463 0 obj << /Dest [34 0 R /XYZ 515 406 null] /Title ( ) /Prev 1462 0 R /Parent 1454 0 R >> endobj 1450 0 obj << /Count 3 /Dest [34 0 R /XYZ 70 476 null] /First 1451 0 R /Last 1453 0 R /Title (P) /Prev 1445 0 R /Parent 343 0 R /Next 1454 0 R >> endobj 1454 0 obj << /Count 9 /Dest [34 0 R /XYZ 70 462 null] /First 1455 0 R /Last 1463 0 R /Title (P) /Prev 1450 0 R /Parent 343 0 R /Next 1464 0 R >> endobj 1466 0 obj << /Dest [34 0 R /XYZ 72 378 null] /Title (References) /Parent 1465 0 R /Next 1467 0 R >> endobj 1467 0 obj << /Dest [34 0 R /XYZ 123 378 null] /Title ( ) /Prev 1466 0 R /Parent 1465 0 R >> endobj 1464 0 obj << /Dest [34 0 R /XYZ 70 395 null] /Title ( ) /Prev 1454 0 R /Parent 343 0 R /Next 1465 0 R >> endobj 1469 0 obj << /Dest [34 0 R /XYZ 72 364 null] /Title (1.) /Parent 1468 0 R /Next 1470 0 R >> endobj 1470 0 obj << /Dest [34 0 R /XYZ 80 364 null] /Title ( ) /Prev 1469 0 R /Parent 1468 0 R /Next 1471 0 R >> endobj 1471 0 obj << /Dest [34 0 R /XYZ 108 364 null] /Title (Allada, R. and J. Bass, Circadian Mechanisms in Medicine. N Engl J Med, 2021. 384\(6\): p. 550-561.) /Prev 1470 0 R /Parent 1468 0 R /Next 1472 0 R >> endobj 1472 0 obj << /Dest [34 0 R /XYZ 128 351 null] /Title ( ) /Prev 1471 0 R /Parent 1468 0 R >> endobj 1465 0 obj << /Count 2 /Dest [34 0 R /XYZ 72 378 null] /First 1466 0 R /Last 1467 0 R /Title (References) /Prev 1464 0 R /Parent 343 0 R /Next 1468 0 R >> endobj 1474 0 obj << /Dest [34 0 R /XYZ 72 338 null] /Title (2.) /Parent 1473 0 R /Next 1475 0 R >> endobj 1475 0 obj << /Dest [34 0 R /XYZ 80 338 null] /Title ( ) /Prev 1474 0 R /Parent 1473 0 R /Next 1476 0 R >> endobj 1476 0 obj << /Dest [34 0 R /XYZ 108 338 null] /Title (Borrmann, H., J.A. McKeating, and X. Zhuang, The Circadian Clock and Viral Infections. J Biol Rhythms, 2021. 36\(1\): p. 9-22.) /Prev 1475 0 R /Parent 1473 0 R /Next 1477 0 R >> endobj 1477 0 obj << /Dest [34 0 R /XYZ 243 324 null] /Title ( ) /Prev 1476 0 R /Parent 1473 0 R >> endobj 1468 0 obj << /Count 4 /Dest [34 0 R /XYZ 72 364 null] /First 1469 0 R /Last 1472 0 R /Title (1.) /Prev 1465 0 R /Parent 343 0 R /Next 1473 0 R >> endobj 1479 0 obj << /Dest [34 0 R /XYZ 72 311 null] /Title (3.) /Parent 1478 0 R /Next 1480 0 R >> endobj 1480 0 obj << /Dest [34 0 R /XYZ 80 311 null] /Title ( ) /Prev 1479 0 R /Parent 1478 0 R /Next 1481 0 R >> endobj 1481 0 obj << /Dest [34 0 R /XYZ 108 311 null] /Title (Maini, M.K. and A.R. Burton, Restoring, releasing or replacing adaptive immunity in chronic hepatitis B. Nat Rev Gastroenterol Hepatol, 2019. 16\(11\): p. 662-675.) /Prev 1480 0 R /Parent 1478 0 R /Next 1482 0 R >> endobj 1482 0 obj << /Dest [34 0 R /XYZ 416 297 null] /Title ( ) /Prev 1481 0 R /Parent 1478 0 R >> endobj 1473 0 obj << /Count 4 /Dest [34 0 R /XYZ 72 338 null] /First 1474 0 R /Last 1477 0 R /Title (2.) /Prev 1468 0 R /Parent 343 0 R /Next 1478 0 R >> endobj 1484 0 obj << /Dest [34 0 R /XYZ 72 284 null] /Title (4.) /Parent 1483 0 R /Next 1485 0 R >> endobj 1485 0 obj << /Dest [34 0 R /XYZ 80 284 null] /Title ( ) /Prev 1484 0 R /Parent 1483 0 R /Next 1486 0 R >> endobj 1486 0 obj << /Dest [34 0 R /XYZ 108 284 null] /Title (Zhuang, X., et al., Circadian control of hepatitis B virus replication. 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