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Professor of Virology

About

Research in the Breuer lab focusses on the application of next generation sequencing and phylogentics to virus diagnostics and discovery.

Research summary

My laboratory has pioneered whole pathogen genome sequencing directly form clinical material using targeted enrichment methods which obviate the need for prior amplification by culture or PCR. We have established the method as an automated high throughput pipeline with associated bioinformatics.

Our research interests include:

1. The evolution of pathogens in the context of disease, drug treatment and vaccination
2. The application of next generation sequencing methodologies to diagnostic microbiology
3. Genomic approaches to host pathogen interactions.

Our current projects include:

1. Genomic approaches to understand the evolution of drug resistance in pathogens and identify the mechanisms of drug action
2. Genomic approaches to understanding the transmission and spread of pathogens
3. Genomic approaches to pathogenesis of infectious diseases.

Selected publications

• Depledge DP, Ouwendijk WJD, Sadaoka T, Braspenning SE, Mori Y, Cohrs RJ, Verjans GMGM, Breuer J. . Nat Commun. 2018. 9(1):1167
• Morfopoulou S, Mee ET, Connaughton SM, Brown JR, Gilmour K, Chong WK, Duprex WP, Ferguson D, Hubank M, Hutchinson C, Kaliakatsos M, McQuaid S, Paine S, Plagnol V, Ruis C, Virasami A, Zhan H, Jacques TS, Schepelmann S, Qasim W, Breuer J. . Acta Neuropathol. 2017. 133(1):139-147
• Sadaoka T, Depledge DP, Rajbhandari L, Venkatesan A, Breuer J, Cohen JI. . Proc Natl Acad Sci U S A. 2016. 113(17):E2403-12
• Morfopoulou S, Brown JR, Davies EG, Anderson G, Virasami A, Qasim W, Chong WK, Hubank M, Plagnol V, Desforges M, Jacques TS, Talbot PJ, Breuer J. . N Engl J Med. 2016. 375(5):497-8
• Depledge DP, Kundu S, Jensen NJ, Gray ER, Jones M, Steinberg S, Gershon A, Kinchington PR, Schmid DS, Balloux F, Nichols RA, Breuer J. . Mol Biol Evol. 2014. 31(2):397-409
• Weinert LA, Depledge DP, Kundu S, Gershon AA, Nichols RA, Balloux F, Welch JJ, Breuer J. . Mol Biol Evol. 2015. 32(4):1020-8
• Jones M, Dry IR, Frampton D, Singh M, Kanda RK, Yee MB, Kellam P, Hollinshead M, Kinchington PR, O'Toole EA, Breuer J. . PLoS Pathog. 2014. 10(1):e1003896
• Brown JR, Roy S, Ruis C, Yara Romero E, Shah D, Williams R, Breuer J. . J Clin Microbiol. 2016. 54:2530-7
• Houldcroft CJ, Beale MA, Breuer J. . Nat Rev Microbiol. 2017.15(3):183-192
• Warren-Gash C, Breuer J. . Nat Rev Neurol. 2016. 12(12):682-683.